Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Mycobacterium tuberculosis (Mtb) infection elicits both protein and lipid antigen-specific T cell responses. However, the incorporation of lipid antigens into subunit vaccine strategies and formulations has been under-explored, and the properties of vaccine-induced Mtb lipid-specific memory T cells have remained elusive. Mycolic acid (MA), a major lipid component of the...
Keyword:: T cell, nanoparticle, CD1, vaccine, and tuberculosis
Subject:: Microbiology and Immunology
Creator:: Morgun, Eva
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_1015444 and http://dissertations.umi.com/northwestern:16794

Description:: Nucleic acid therapeutics can be drug molecules with high programmability, minimal off-target effects, and the capability to address “undruggable” targets for diseases. In addition, each time a new drug is needed, one needs to only change the sequence as opposed to finding an entirely new structure. One nucleic acid type...
Keyword:: RNAi, siRNA, gene therapy, structure-function, spherical nucleic acid, and nanoparticle
Subject:: Nanotechnology, Pharmaceutical sciences, and Biomedical engineering
Creator:: Vasher, Matthew Kuo
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_938909 and http://dissertations.umi.com/northwestern:16319

Description:: Nanocarriers are nanometer-sized (1-1000 nm) structures capable of encapsulating cargo. This encapsulation can drastically alter the pharmacokinetic properties of the cargo, while also allowing for the rational design and engineering of the nanocarrier itself. Poly(ethylene glycol)-block-poly(propylene sulfide) is an amphiphilic diblock copolymer capable of self-assembling into diverse nanocarriers. The purpose...
Keyword:: flash nanoprecipitation, nanoparticle, copolymer, anti-inflammatory, and PEG-b-PPS
Subject:: Biomedical engineering and Biology
Creator:: Allen, Sean David
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14509 and etdadmin_upload_638353

Description:: When attached to another species (e.g. a nanoparticle), the sequence specificity of DNA can be repurposed to program interactions between such entities and to direct their formation into ordered structures. The research presented in this thesis aims to push the boundaries of structures that can be made via this approach....
Keyword:: image analysis, nanoparticle, DNA, symmetry breaking, high-throughput, and crystal engineering
Subject:: Nanotechnology, Chemistry, and Chemical engineering
Creator:: Laramy, Christine
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_617692 and http://dissertations.umi.com/northwestern:14404

Description:: Nano-scale materials possess many unique physical and chemical properties which are not found in bulk materials. The ability to synthesize these materials by design is one of the greatest challenges in materials science. Advances towards meeting this challenge will lead to discoveries in fields such as plasmonics, photonics, catalysis, and...
Keyword:: self-assembly, nanoparticle, DNA, Molecular Dynamics, and Monte Carlo
Creator:: Saijie Pan
Owner:: Scholarly Digital Publishing
Date Uploaded:: 11/24/2019
Date Modified:: 11/24/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Description:: Metallic nanostructures are able to confine and manipulate electromagnetic fields because light can couple to free electron oscillations called surface plasmons (SPs). These plasmons exist on metal surfaces as localized (short-range) or as propagating (long-range) modes depending upon the size and geometry of the nanostructure. This dichotomy is primarily an...
Keyword:: plasmon, nanoscience, nanoparticle, Metamaterials, subwavelength holes, and nanopatterning
Subject:: Chemistry
Creator:: Joel Henzie
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/29/2018
Date Modified:: 08/29/2018
Date Created:: 2007-12-10
Resource Type:: Dissertation

Description:: Continuous fiber/epoxy composites have been widely used for structural applications due to their excellent mechanical properties, but the benefits of using these composites is limited by their lower than desired matrix-dominated properties. In this study, epoxy matrix in carbon fiber/epoxy composites was modified with graphite nanoplatelets to improve their mechanical...
Keyword:: processing, nanocomposites, nanoparticle, composite laminate, hybrid composites, and prepreg
Subject:: Theoretical and Applied Mechanics
Creator:: Jui-Ying Chen
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/28/2018
Date Modified:: 08/28/2018
Date Created:: 2007-11-26
Resource Type:: Dissertation

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