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Filtering by: Keyword neuroinflammation Resource type Dissertation Subject Integrated Graduate Program in the Life Sciences

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Description:: Early-life seizures increase susceptibility to seizures in adulthood. However, mechanisms by which seizures in the developing brain lead to increased vulnerability to seizures and exacerbation of neurological injury in adulthood remain unknown. We test the hypothesis that upregulation of proinflammatory cytokine levels and chronic glial activation following early-life seizures result...
Keyword:: seizures, cytokines, microglia, glia, glutamate, and neuroinflammation
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kathleen Cua Somera-Molina
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

Description:: There is increasing evidence that links chronic activation of glial cells and the subsequent self-propagating cycle of neuroinflammation to the neurodegenerative progression of Alzheimer's disease (AD). Nevertheless, attempts to identify currently approved drugs capable of safely attenuating the neuroinflammatory processes in AD have proven disappointing to date, and the development...
Keyword:: neuroinflammation, beta-amyloid, glia, and Alzheimer's disease
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Jeffrey Michael Craft
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/10/2018
Date Modified:: 05/10/2018
Date Created:: 2007-03-05
Resource Type:: Dissertation

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