The neurotropic alphaherpesviruses infect and spread trans-synaptically within the vertebrate nervous system. Recurrent diseases are often manifested at the periphery of the host organism but occasional dissemination of the virus to the brain results in fatal encephalitis. Interactions between viral and host cellular proteins are integral to the success of...
The brain is known to shrink in normal aging or neurodegenerative disease and yet the neurobiological underpinnings of the cortical atrophy remain elusive. The structural changes that represent cortical atrophy can be measured during life using the reliable and quantitative method known as magnetic resonance imaging (MRI). Primary progressive aphasia...