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Genome-Scale Transcriptional Analysis of Megakaryocytic Cell Cultures Reveals Insights into Lineage-Specific Differentiation

Description:

Little is known about the transcriptional events underlying megakaryocytic (Mk) differentiation from hematopoietic stem cells. We sought to identify genes and pathways not previously associated with megakaryopoiesis and to evaluate the CHRF-288-11 (CHRF) megakaryoblastic cell line as a model system for investigating megakaryopoiesis. Using DNA microarrays, Q-RT-PCR, and protein-level assays,...

Keyword:

p53, microarray, differentiation, apoptosis, polyploidization, and megakaryocyte

Subject:

Chemical and Biological Engineering

Creator:

Peter Gebhard Fuhrken

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/06/2018

Date Modified:

08/06/2018

Date Created:

2007-07-12

Resource Type:

Dissertation
Mechanisms of hyperoxia-induced senescence in primary human lung fibroblasts

Description:

Senescence, permanent, irreversible replication arrest that occurs in all primary cells studied to date, is considered a cellular model of aging. Recently, senescence has gained attention as a potential tumor-suppressing mechanism. However, despite the obvious importance of senescence, its exact mechanisms remain unclear. One current hypothesis to explain senescence postulates...

Keyword:

aging, p53, hyperoxia, senescence, and reactive oxygen species

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Tatyana A Klimova

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/10/2018

Date Modified:

09/10/2018

Date Created:

2008-05-08

Resource Type:

Dissertation

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Genome-Scale Transcriptional Analysis of Megakaryocytic Cell Cultures Reveals Insights into Lineage-Specific Differentiation

Mechanisms of hyperoxia-induced senescence in primary human lung fibroblasts

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