The term Connected Vehicle (CV) is broadly used to identify any ‘smart vehicle’ with wireless connectivity to the roadside infrastructure and other vehicles. CVs that can be driven autonomously are called connected autonomous vehicles (CAVs). With real-time communication and data transmission capability, CAVs have the potential to improve the transportation...
Actin polymerization is responsible for the protrusion of filopodia and lamellipodia in immune, cancer, and other motile cells, as well as for propulsion of some intra cellular pathogens. Protrusion of a lamellipodium by the very filaments supporting the membrane load operates by the Brownian ratchet mechanism, with overall organization governed...
The macroscale mechanical and physical properties of materials are inherently linked to the underlying microstructure. Traditional continuum mechanics theories have focused on approximating the heterogeneous microstructure as a continuum, which is conducive to a partial differential equation mathematical description. Although this makes large scale simulation of material much more efficient...
In financial risk management, coherent risk measures have been proposed as a way to avoid undesirable properties of measures such as value at risk that discourage diversification and do not account for the magnitude of the largest, and therefore most serious, losses. A coherent risk measure equals the maximum expected...
Research shows that the most effective way to teach learners targeted skills is to put them in the kinds of situations in which they need to use them and to provide experts who are able to advise learners when necessary (Schank & Cleary, 1995). Through this process, learners come to...
We introduce and advocate a new paradigm in simulation experiment design and analysis, called ``green simulation,'' for the setting in which experiments are performed repeatedly with the same simulation model but different input parameters. In this dissertation three classes of green simulation estimators are proposed: the likelihood-ratio-based estimators, the metamodeling-based...
Science at the nanoscale poses several recurring difficulties. How can we control the assembly of objects too small for direct manipulation to be practical? How can we extend that control to extit{in vivo} systems so we can make use of nanotechnology in medicine? And how can we recreate the extraordinary...
For stochastic simulation optimization in a modern computing era, we introduce a new parallel framework for solving very large-scale problems using a ranking & selection (R&S) approach that simulates all systems or feasible solutions to provide a global statistical guarantee. We propose a parallel adaptive survivor selection (PASS) framework that...
Polymer nanocomposites have attracted great interest in recent years because of their potential as tailored materials with enhanced properties. Recent experiments have shown that polymer nanocomposites are able to achieve significant improvement in dielectrical, thermal, mechanical and other physical properties compared with their parent polymer systems. More importantly, these outstanding...
The production and spread of digital news involves a wide range of actors: journalists and the organizations that employ them, social media platforms, audiences, and myriad commentators, citizen journalists, bloggers, and other actors who contribute to the news ecosystem without inhabiting an official role. These actors interact in flexible, often...