When navigating through space, the brain must integrate sensory information with past experiences to choose behaviors that are most likely to produce a positive outcome. Striatal medium spiny neurons (MSNs) expressing dopamine receptor 1 (D1) and dopamine receptor 2 (D2) receive sensory and motor information from cortical and midbrain regions...
The striatum is a subcortical nucleus that regulates a number of complex activities ranging from voluntary action selection to the subconscious formation of habit. The coordination of these operations is mediated by the principle cells of the striatum, spiny projection neurons (SPNs). SPN activity is dictated by a confluence of...