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Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Description:

Early Growth Response genes (Egr1-4) are transcriptional mediators of signals governing growth and differentiation. In sympathetic neuron-derived cell lines, Egr1 is induced by NGF signaling, which is required for sympathetic neuron survival, differentiation and target organ innervation. In the absence of identifiable sympathetic defects in Egr1-deficient mice, we investigated the...

Keyword:

NGF, sympathetic nervous system, and Egr3

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Laurie Christine Eldredge

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/01/2018

Date Modified:

10/01/2018

Date Created:

2008-12-08

Resource Type:

Dissertation
The role of early growth response transcriptional regulators in neurotrophin signaling and sympathetic nervous system development

Description:

Early growth response genes (Egr1-4) are induced as immediate early genes by a variety of extracellular stimuli that influence cellular growth and differentiation. Egr transcriptional regulators modulate gene expression by binding to Egr response elements (ERE) in target genes. In this study, the low affinity p75 neurotrophin receptor (p75NTR) was...

Keyword:

Egr, sympathetic nervous system, dnEgr, neurotrophin signaling, and p75NTR

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Xiaoguang Guo

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/02/2018

Date Modified:

08/02/2018

Date Created:

2007-05-31

Resource Type:

Dissertation

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Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

The role of early growth response transcriptional regulators in neurotrophin signaling and sympathetic nervous system development

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