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The Role of the N-terminus of Tau in Alzheimer's Disease

Description:

The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...

Keyword:

Alzheimer's disease, tangle, N-terminus, frontotemporal dementia, and tau

Subject:

Neuroscience Institute Graduate Program

Creator:

Peleg Moshe Horowitz

Owner:

Scholarly Digital Publishing

Date Uploaded:

05/07/2018

Date Modified:

05/07/2018

Date Created:

2006-11-16

Resource Type:

Dissertation