Northwestern University

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Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

Description:

Mycobacterium tuberculosis (Mtb) infection elicits both protein and lipid antigen-specific T cell responses. However, the incorporation of lipid antigens into subunit vaccine strategies and formulations has been under-explored, and the properties of vaccine-induced Mtb lipid-specific memory T cells have remained elusive. Mycolic acid (MA), a major lipid component of the...

Keyword:

T cell, nanoparticle, CD1, vaccine, and tuberculosis

Subject:

Microbiology and Immunology

Creator:

Morgun, Eva

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

08/23/2023

Date Created:

2023-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_1015444 and http://dissertations.umi.com/northwestern:16794