This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
This project explores how the variation in language experiences and attitudes that Mexican American Spanish heritage speaker bilinguals in the United States have affects their speech perception in both their languages. Heritage language bilinguals speak as a first language a minority language that they have cultural ties to (e.g., Spanish...
This dissertation investigates how scope relations are constructed and evaluated during real-time human sentence processing. Theoretical approaches to processing scope relations exist in a multi-dimensional space where trade-offs are made around how quickly scope relations can be computed, how many mistakes are made in computing scope relations, and how many...
Transitioning energy systems from a reliance on fossil fuels to low carbon energy sources is an essential solution for climate change mitigation. However, the industrial sector, which is directly responsible for more than a quarter of global carbon dioxide (CO2) emissions, continues to use fossil fuels for energy and feedstocks....
Necessity is the mother of innovation. In the wake of the pandemic, with no flow of samples and limited fabrication techniques available, necessity demanded a new material platform and adaptable methods to make complex oxide samples worth measuring. The material platform was KTaO3 , the younger successor to the mainstay...
Despite the increasing interest in biogenic secondary organic aerosols (SOAs), their role in the climate system remains the greatest source of uncertainty in global models. Cloud formation, critical for the net cooling effect provided by cloud cover, is dependent on the abundance of SOA particles and their ability to activate...
Controlled delivery of foreign cargo into cells is a critical step in many biological studies and in cell engineering and analysis workflows. Recent advances in micro and nanotechnology, specifically in microfluidics and microfabrication have added significantly to the precision, accuracy, resolution and throughput of cell manipulation and analysis pipelines. These...
Metalloenzymes catalyze remarkable reactions in Nature using transition metal ions. Common earth-abundant metals like copper, iron, zinc, and magnesium catalyze reactions that are the basis of life. These metal sites lend their chemistries to facilitate these reactions, making studying the structure and properties important in understanding the enzymes' abilities and...
Drying oils have been used as a binding medium for oil paints since the 15th century. These oil paints transition from a liquid-like paste to a solid-like film as a result of crosslinks forming between the oil molecules. These reactions have been extensively studied chemically, but other material properties are...
This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...