Impairments in the social use of language, or pragmatics, constitute a core characteris-tic of autism. Problems with pragmatic language have also been documented in fragile X syndrome (FXS), a monogenic condition that is the most common known genetic cause of autism. Evidence suggests that social cognitive ability, or theory of...
With the advent of a variety of novel nanometer-scale diagnostic techniques such as DNA micro- and nanoarrays, increasing focus has been placed on developing methods to quickly and accurately create these nanometer scale patterns. One promising technique for depositing DNA, proteins, and other liquid molecular "inks" with submicron resolution is...
Magnetic nanostructures (MNS) have become the subject of intense
interest due to their superparamagnetic properties and consequently
their potential uses in medical diagnostics and therapeutics. In this
study, monodisperse magnetite MNSs were synthesized via thermal
decomposition of iron(III) acetylacetonate and transferred to aqueous
solution using 11-aminoundecanoic acid as the surfactant....
Neurons are difficult to manipulate experimentally. Most transfection
reagents used for gene silencing are neurotoxic, and the postmitotic
state of neurons prevents the effective use of viral vectors. This study
demonstrated the delivery of antisense DNA against target genes by
gold nanoparticle oligonucleotide complexes (GNOs) in primary cultures
Alzheimer’s disease (AD) is one of the most common forms of dementia,
with no current definitive premortem diagnosis. Amyloid beta-peptide
derived diffusible ligands, known as ADDLs, have become a key link in
the AD specificity for memory loss and are a potential biomarker for AD.
In order to develop an...
Thermoelectric materials, which convert heat energy to electrical
energy, may become increasingly important in the world’s energy
situation. Through the inclusion of nanoscale features embedded within
a thermoelectric bulk material, it has been shown that a corresponding
decrease in lattice thermal conductivity results in an enhanced
thermoelectric figure of merit,...
Under the correct conditions, aluminum can be anodized in an electrochemical
cell to produce hexagonally ordered arrays of nanoscale
pores. This study examines how adding the chemicals methanol and
acetic acid to a typical anodization solution alters pore-growth patterns
across the surface oxide layer. The existence of the unique pore-growth...
This paper investigates the use of self-assembled monolayers
(SAMs) to optimize the localized surface plasmon resonance (LSPR)
biosensor for disease detection. Various experiments were done
with 1-(9-mercaptononyl)-3,6,9-trioxaundecan-11-ol (TDT) and
heptaoxatricosanoic acid (HSA), a new SAM; these included a solvent
study to determine refractive index sensitivity and nonspecific binding
Cadmium selenide (CdSe) quantum dots have low conductivity upon
synthesis with the original capping ligands. The conductivity can be
altered by the addition of other ligands. Thiols, amines, and carboxylic
acids, as well as other functional groups, have been shown to improve
conductivity in quantum dot films. This investigation describes...
This study examined the invasiveness of nanofountain probes (NFP)
when used as a transfection tool for single-cell research. For comparison,
the damage caused to cells by more commonly used commercial
atomic force microscope (AFM) probes was also studied. Forces were
applied to cells at increasing levels using both probes, and...