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- Description:
- Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the heart and central nervous system where they regulate membrane excitability. Recently, inhibiting HCN channels in the hippocampus has been identified as a possible therapeutic intervention for the treatment of Major Depressive Disorder (MDD). However, based on the high expression level of...
- Keyword:
- HCN, OPC, Oligodendrocyte, TRIP8b, and Depression
- Subject:
- Neuroscience, Biochemistry, and Developmental Biology
- Creator:
- Kyle Andrew Lyman
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 06/17/2019
- Date Modified:
- 06/17/2019
- Date Created:
- 2016-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- https://doi.org/10.21985/N2W781
-
- Description:
- SAMDI-MS, which stands for self-assembled monolayers (SAMs) for matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS), is a powerful tool that has enabled the development of novel high-throughput screening and experimentation methods for decades. SAMDI-MS works by immobilizing analytes to functionalized SAMs prior to MS analysis and is capable of...
- Subject:
- Bioengineering, Molecular biology, and Biochemistry
- Creator:
- Pluchinsky, Adam John
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_885633 and http://dissertations.umi.com/northwestern:15968
-
- Description:
- Genetic studies have found variants in the protein-degrading autophagy-lysosomal pathway (ALP) to be among the most common risk factors for developing Parkinson’s disease (PD). Macroautophagy (MA) is the arm of this pathway which delivers cytosolic components to lysosomes for degradation and is essential for neuronal health. The defining pathological protein...
- Keyword:
- ykt6, synuclein, Parkinson disease, SNARE, autophagy, and farnesyltransferase inhibitor
- Subject:
- Molecular biology, Biochemistry, and Neurosciences
- Creator:
- Pitcairn, Caleb
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16447 and etdadmin_upload_970290
-
- Description:
- Proteins represent a critical class of biomolecules, universally employed by all living organisms to fulfill essential structural, functional, and enzymatic roles necessary to support life. In nature, these polymers are composed generally of twenty natural amino acid (AA) building blocks, which can be modified with covalent adducts known as post-translational...
- Keyword:
- post-translational modification, genome engineering, cell-free protein synthesis, synthetic biology, orthogonal translation system, and non-canonical amino acid
- Subject:
- Bioengineering, Biology, and Biochemistry
- Creator:
- Des Soye, Benjamin James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14473 and etdadmin_upload_627384
-
- Description:
- Methanotrophs, bacteria that can metabolize methane, remain a promising solution to mitigating the effects of climate change by removing atmospheric methane and converting it to useful chemical precursors. However, a full understanding of the main enzyme they use to oxidize methane, particulate methane monooxygenase (pMMO), is critical for harnessing their...
- Keyword:
- cryogenic electron tomography, particulate methane monooxygenase, membrane protein, cryogenic electron microscopy, and cell-free protein synthesis
- Subject:
- Molecular biology, Biochemistry, and Biophysics
- Creator:
- Koo, Christopher Wellington
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_897671 and http://dissertations.umi.com/northwestern:16003
-
- Description:
- The treatment of AML remains to be a challenge due to the high rates of resistance and relapse experienced by patients after initial therapy. The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for AML due to their critical role in malignant hematopoietic transformation via...
- Subject:
- Molecular biology, Biology, and Biochemistry
- Creator:
- Suarez Palacios, Milagros Melanie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_845430 and http://dissertations.umi.com/northwestern:15772
-
- Description:
- Heat shock factor 1 (HSF1) is well known for its role in the heat shock response (HSR), where it drives a transcriptional program comprising heat shock protein (HSP) genes, and in tumorigenesis, where it drives a program comprising HSPs and many noncanonical target genes that support malignancy. Here, we find...
- Subject:
- Biochemistry
- Creator:
- Smith, Roger Stephen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_902929 and http://dissertations.umi.com/northwestern:16081
-
- Description:
- Transfer of information across membranes is fundamental to the function of all organisms and is primarily initiated by transmembrane receptors. This is an allosteric process and involves conformational coupling between ligand-binding domain and signaling domain of a receptor. This allosteric mechanism of activation is unclear for many receptors. Moreover, for...
- Keyword:
- GPCR, CaSR, and smFRET
- Subject:
- Bioinformatics, Biochemistry, and Biophysics
- Creator:
- Schamber, Michael Robert
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16268 and etdadmin_upload_929368
-
- Description:
- MYC regulates multiple gene programs, raising questions about the potential selectivity and downstream transcriptional consequences of MYC inhibitors as cancer therapeutics. MYC func-tions to either globally amplify RNA production or selectively regulates genes by repression or ac-tivation. In models of MYC inhibition by small molecules the functionality of MYC is...
- Subject:
- Molecular biology and Biochemistry
- Creator:
- Holmes, Austin Gable
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_904142 and http://dissertations.umi.com/northwestern:16111
-
- Description:
- Breakthroughs in large-scale biological data collection have resulted in a wealth of -omics (genomics, metabolomics, etc.) datasets in the literature. However, the development of appropriate computational techniques for their analysis is lacking, yet crucial for fully extracting the rich information contained in these datasets. The work in this dissertation describes...
- Keyword:
- Biorecording, Data Storage, Cheminformatics, Metabolomics Annotation, Machine Learning, and TdT
- Subject:
- Bioengineering, Bioinformatics, and Biochemistry
- Creator:
- Strutz, Jonathan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_911481 and http://dissertations.umi.com/northwestern:16126
-
- Description:
- Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...
- Keyword:
- GBM, Spherical nucleic acids, cGAS, Immunotherapy, and STING
- Subject:
- Biology, Biochemistry, and Immunology
- Creator:
- Mahajan, Akanksha Sanjay
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_983546 and http://dissertations.umi.com/northwestern:16516
-
- Description:
- The interaction of amyloid-β (Aβ) with endogenous metal ions is thought to play a role in the pathogenesis of Alzheimer’s disease (AD). However, limited tools exist to study and modulate Aβ-metal binding. The Meade lab has developed cobalt(III) Schiff base (Co(III)-sb) complexes as protein inhibitors that competitively displace metals from...
- Keyword:
- amyloid-beta, aggregation, cobalt(III) Schiff base, and coordination complex
- Subject:
- Biology, Biochemistry, and Neurosciences
- Creator:
- Roberts, Kaleigh Filisa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_773649 and http://dissertations.umi.com/northwestern:15349
-
- Description:
- Methylation of histone 3 lysine 4 (H3K4) catalyzed by the COMPASS family of lysine methyltransferases is universally associated with eukaryotic transcription. However, despite thousands of published studies examining the deposition, dynamics, and genomic positions of this chromatin modification, there is no clear consensus as to the molecular function or biological...
- Subject:
- Biochemistry
- Creator:
- Rickels, Ryan A
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14787 and etdadmin_upload_682860
-
- Description:
- This work combines the use of high-throughput mass spectrometry with peptide arrays for to monitor reactions on peptides. The Mrksich lab introduced a high-throughput, label-free, biochemical assay that relies on self-assembled monolayers on gold and matrix-assisted laser desorption/ionization mass spectrometry, termed SAMDI-MS. This dissertation introduces new applications of SAMDI-MS and...
- Keyword:
- High-throughput, SAMDI, Phosphatase, Mass spectrometry, and Peptide Arrays
- Subject:
- Chemistry and Biochemistry
- Creator:
- Szymczak, Lindsey Catherine
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14701 and etdadmin_upload_667038
-
- Description:
- The work in this thesis focuses on computational methods for the identification of novel enzymatic pathways. In particular this work focuses on the utilization of the Biological Network Integrated Computational Explorer (BNICE) software suite to predict de novo enzymatic pathways for the production of commercially relevant compounds and on improvements...
- Subject:
- Bioengineering and Biochemistry
- Creator:
- Stine, Andrew Eugene
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2016-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_614431 and http://dissertations.umi.com/northwestern:14393
-
- Description:
- DNA double-strand breaks (DSBs) are caused by either endogenous agents or exogenous ionizing radiation and chemicals. Incorrect DSB repair can lead to undesired genome rearrangements. Homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways are two major DNA repair pathways that repair DSBs and maintain genome integrity. When homologous DNA is...
- Keyword:
- DNA repair, Cryo EM, NHEJ, DNA-PKcs, Cancer, and CRISPR
- Subject:
- Molecular biology, Biochemistry, and Biophysics
- Creator:
- Chen, Siyu
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_879511 and http://dissertations.umi.com/northwestern:15936
-
- Description:
- G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in humans and play a role in nearly all physiological processes. Among GPCRs, metabotropic glutamate receptors (mGluRs) are a structurally distinct family of synaptic receptors that are essential in regulating neurotransmission and synaptic plasticity. Due to their important regulatory...
- Keyword:
- structural dynamics, mGluRs, conformational dynamics, membrane proteins, smFRET, and GPCRs
- Subject:
- Pharmacology, Biochemistry, and Biophysics
- Creator:
- Liauw, Brandon Wey-Hung
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_937523 and http://dissertations.umi.com/northwestern:16310
-
- Description:
- Nuclear receptors (NRs) are an important family of transcription factors that often regulate genes in response to ligands and by way of direct interactions with coactivator proteins. Many NR-coactivator pairs have been identified that cooperate to regulate transcription but fully understanding how NRs recruit specific coactivators involves learning which of...
- Keyword:
- Transcriptional Regulation, NMR, and Nuclear Receptors
- Subject:
- Biology, Biochemistry, and Biophysics
- Creator:
- Daffern, Nicolas
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16121 and etdadmin_upload_910580
-
- Description:
- Cobalt(III) Schiff-base complexes (Co(III)-sb) have been utilized in the literature as antibacterial, antiviral, and inhibitory agents. Recent work has utilized their ability to displace endogenous metals from metalloproteins that exhibit aberrant gain of function pathologies in human disease. Specifically, in this dissertation Co(III)-sb has been applied as inhibitors of pathogenic...
- Keyword:
- Transcription Factors, Coordination Complexes, Cobalt, Amyloid-beta, Molecular Dynamics, and Intrinsically Disordered Proteins
- Subject:
- Chemistry, Biochemistry, and Biophysics
- Creator:
- Brue, Christopher Robert
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15862 and etdadmin_upload_863221
-
- Description:
- SAMDI-MS (Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry) couples the use of chemically-defined self-assembled monolayers of alkane thiolates on gold surfaces with MALDI-TOF mass spectrometry for rapid characterization of the surfaces. Reactions performed on the surfaces can be quantified directly by detection of the reaction substrates and products. This rapid detection...
- Keyword:
- SAMDI, mass spectrometry, bioassay, chromodomains, cell-free reactions, and microfluidics
- Subject:
- Analytical chemistry, Materials Science, and Biochemistry
- Creator:
- O'Kane, Patrick Thomas
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14615 and etdadmin_upload_661860
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