Index Catalog // Arch : Northwestern University Institutional Repository

Description:: The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due...
Keyword:: calcium cycling, spontaneous contraction, high-throughput, cardiomyocyte, direct reprogramming, and fibroblast
Subject:: Biology, Cellular biology, and Developmental biology
Creator:: Romero Tejeda, Marisol
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_970274 and http://dissertations.umi.com/northwestern:16446

Description:: One of the fundamental questions in developmental biology is how a single cell gives rise to a complex organism. More specifically, how a totipotent egg divides into cells that become increasingly restricted in their potential. Development is a process of increasingly restricted cellular potential, and here I home in on...
Keyword:: Xenopus, Pluripotency, Neural Default Model, BMP, Smads, and Activin
Subject:: Biology and Developmental biology
Creator:: Johnson, Kristin Lorette
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16347 and etdadmin_upload_945075

Description:: Pattern formation of biological structures involves the arrangement of different types of cells in an ordered spatial configuration. Patterning is thought to involve the spatial organization of molecular pre-patterns that precede and drive subsequent cell differentiation and coinciding morphogenesis. These molecular prepatterns are often, although not exclusively, organized through Turing...
Keyword:: emergence, compound eye, self organization, Drosophila, morphogenesis, and pattern formation
Subject:: Biology, Biophysics, and Developmental biology
Creator:: Gallagher, Kevin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16245 and etdadmin_upload_928342

Description:: A variety of human diseases and pregnancy related disorders reflect endometrial dysfunction. However, rodent models do not share fundamental biological processes with the human endometrium, such as cyclic menstruation, and no existing human cell cultures recapitulate the cyclic interactions between endometrial stromal and epithelial compartments necessary for decidualization and implantation....
Keyword:: human endometrial organoid, pluripotent stem cells, epithelial-stromal signaling, cyclic hormone response, human endometrial stromal cells, and human decidua
Subject:: Biology and Developmental biology
Creator:: Chu, Virginia
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15366 and etdadmin_upload_776955

Description:: Proper spatiotemporal expression of genes is essential during development. One method of regulation of signaling-responsive genes is at the level of transcription. In this work, I present the adaptation of single molecule fluorescent in situ hybridization for use in Drosophila imaginal disc tissues in order to more precisely quantify transcript...
Keyword:: gene expression, transcription, microscopy, bursting, in situ hybridization, and drosophila
Subject:: Systematic biology, Biology, and Developmental biology
Creator:: Bakker, Rachael
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15416 and etdadmin_upload_780973

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