Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we used dynamic metabolic labeling with stable isotopes followed by proteomic...
This dissertation addresses questions in the fields of household finance and corporate finance. In Chapter 1, I use a quasi-experiment in Norway to examine how households respond to capital taxation. The introduction of a new wealth assessment methodology in 2010 led to geographic discontinuities in household exposure to wealth taxes,...
In the short amount of time that genetic manipulation has been possible through CRISPR technology, myriad applications have been developed. Results from one of the most promising applications of this technology, pooled screens, have shown that single guide RNAs (sgRNAs), RNA sequences used to target specific regions of the genome,...
Background: Cancer-related cognitive impairment (CRCI) is among the most frequently reported adverse events during and following cancer treatment. Between 17% to 75% of chemotherapy-treated cancer patients evidence long-term cognitive deficits as many as 20 years after treatment. The variability in prevalence and the mechanisms of persistent CRCI are not well...
This dissertation is a contribution to the depth and breadth of prison media history. I position prison media of the 1970s as key antecedents to the prison reality television of the 2000s and today. The purpose of this arrangement is to bring attention to an era of prison media that...
Organic chromophores show great promise for energy and optoelectronic devices, due to their synthetic tunability and low production costs. In order to achieve this potential, their fundamental photophysical processes must be better understood. It has long been documented that chromophore packing at the molecular level has dramatic effect on electronic...
The philosophical literature on modals is dominated by the following paradigm: modals are modeled as quantifiers over sets of possible worlds. The diversity of modal “fla- vors” (e.g., epistemic, deontic, teleological interpretations of modals) is accommodated within the paradigm by logical mechanisms that allow extralinguistic factors to restrict the quantificational...
There is a paradox at the center of twenty-first century American poverty. On the one hand, American poverty seems to have become an object of significant interest (at least to scholars and to the reading public)—as evidenced through the surge of wildly successful non-fiction books about poverty. On the other...
I analyze a new mechanism through which changes in aggregate income can result in changes in the labor income distribution. This mechanism arises from heterogeneity in the expenditure elasticity of different sectors and in their employment composition. Once total income increases the mechanism suggests that consumption will be re-allocated towards...
Computational imaging (CI) is a class of imaging systems that optimize both the opto-electronic hardware and computing software to achieve task-specific improvements. Machine/deep learning models have proven effective in drawing statistical priors from adequate datasets. Yet when designing computational models for CI problems, physics-based models derived from the image formation...