Atrial fibrillation (AF) is the most common arrhythmia in adults in the United States. Despite its prevalence, the etiology of AF and its adverse effects are not completely understood, which has made treatment of AF difficult. However, left atrial (LA) fibrosis is associated with worsening and propagating AF. Additionally, research...
This dissertation studies topics in health care operations management related to value-based care, where {\em value} can be thought of as the ratio of quality to cost. The objective in value-based care is to increase, or maximize, value by reducing costs and improving quality health outcomes. In Chapter 1 we...
The mechanism underlying chronic pain and disability in those with chronic whiplash associated disorders (WAD) is poorly understood. Of the four million people who will seek medical care each year for neck injuries sustained during a motor vehicle collision (MVC), a quarter will develop chronic moderate to severe WAD. Disparate...
This dissertation is a broad study on individual and firm-level financial conditions and their effects on politics. In the first chapter, I study the effect of economic conditions on political polarization using micro-data on house prices, mortgages, and individual political contributions. I argue that shocks to housing wealth --- the...
The study of solid-state organic chromophores has been soaring in the last decade owing to their wide applications in organic photovoltaics. These organic chromophores can absorb light in the visible region and form free charge carriers with proper design in molecular structure and device fabrication. In solid state, chromophores are...
Knowledge combination is a fundamental component of technological invention, which is a driver of new economic opportunities and firm growth. Yet, evidence suggests that myriad organizational factors, including managers, weigh heavily on the ability of firms to productively use R&D capabilities. This dissertation argues that managerial attention plays an important...
This thesis revisits classic optimal tax theory, recognizing that most people live in multi-person households. We derive optimal tax schedules for married agents, seriously taking the distinction between interpersonal and interhousehold inequality. After showing how individual-oriented utilitarianism typically leads to a misalignment between the households’ and the government’s objectives, which...
Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...
Transcription of nucleic acids (DNA and RNA) is a hallmark of life, taking the information stored within genomic nucleic acids and converting it into a form that is useful for producing the proteins necessary for cellular and organismal function. In eukaryotes, transcription of DNA into messenger RNA (mRNA) requires the...
Current biomaterials-based methods for in vitro ovarian follicle culture enable individual follicles or follicle classes to survive and carry out basic functions of the ovary, including hormone and release of mature oocytes upon gonadotropin stimulation. However, these current strategies do not support the survival and maturation of isolated primordial and...