The interaction of amyloid-β (Aβ) with endogenous metal ions is thought to play a role in the pathogenesis of Alzheimer’s disease (AD). However, limited tools exist to study and modulate Aβ-metal binding. The Meade lab has developed cobalt(III) Schiff base (Co(III)-sb) complexes as protein inhibitors that competitively displace metals from...
The evolutionarily conserved COMPASS family of methyltransferases implements histone H3 lysine 4 (H3K4) methylation, an epigenetic mark associated with transcriptional activation. Given the high mutational prevalence of COMPASS subunits across cancers and neurodevelopmental disorders, understanding COMPASS function would lend important insights into disease pathogenesis to facilitate development of effective therapies....
Nearly all animals exhibit behaviors that can be classified as sleep. The distinctly disadvantageous nature of the asleep state, evolutionarily speaking, accentuates its role as a critical physiological process, yet chronic inadequate sleep is prevalent in today’s society. Among the multitude of health problems that have been linked to chronic...
The experiences and environments of working-class children vary dramatically from their more affluent peers. I update Bronfenbrenner’s (1986) ecological systems theory to account for the technology children interact with and child social class, using Lareau’s (2003) frameworks that establish class differences in parenting practices. I position child technology devices at...
Pablo Escobar is not only part of Colombia’s cruel past but also of its very difficult present. Escobar was one of the first major modern drug traffickers, and the founder and head of the Medellín Cartel. He was responsible for more than four thousand deaths. He had an incalculable fortune...
Cell-based therapies are an exciting frontier in medicine. This field is built on a simple premise—cells can be engineered to recognize and treat various human diseases. The paradigm of cell-based therapy uses biosensors to interrogate a cell’s environment and distinguish disease from health, intracellular signaling pathways and genetic circuitry to...
This dissertation describes investigations into the two primary mechanisms by which the optical bandgap of colloidal quantum dots (QDs) may be post-synthetically modified: (i) by the quantum-confined Stark effect and (ii) by exciton-delocalizing surface capping ligands. This work demonstrates that through the use of ligand-exchange strategies that enable either of...
Research shows the increasing tendency of political considerations to influence decisions outside the context of politics. This work documents examples of partisan affiliation influencing judgments and behaviors – and often resulting in favoritism or discrimination – in ostensibly nonpolitical contexts such as the workplace, academia, and dating, among others. To...
Basal ganglia are a highly interconnected group of nuclei involved in motor control. The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. While the prevailing basal ganglia circuit model assumes the GPe as merely a relay, phasic changes in the activity of GPe neurons during...
It is said across numerous disciplines, from biology to architecture to software engineering, that “form ever follows function.” This adage highlights the intimate relationship between structural characteristics and functional properties in many disparate fields of work. Here, we discuss how the catalytic activity and compressibility of metal–organic frameworks (MOFs) are...
Sight-singing skills are a key component in empowering choristers to make music independently. Advances in technology have made visual feedback displaying the accuracy of a sight-singing attempt available to singers. The purpose of this study was to examine the effects of computerized visual feedback provided by the SmartMusic interface on...
Deciphering the targets of axonal projections plays a pivotal role in interpreting neuronal function and pathology. Neuronal tracers are indispensable neurobiology tools for elucidating advanced functions and interactions between different subregions of the brain. Commercially available neuronal tracers include small molecule dyes, viruses, and synthetic nanoparticles. Among these options, viral...
Multiteam systems (MTSs), or teams of teams, have recently become a standard for collaboration—ranging from traditional office teams to those setting a course for Mars. Although leadership is often identified as a critical lever for effective MTS functioning and success, there is little research to inform the question of how...
Interpersonal hierarchies are one of the most fundamental structures by which human interactions are organized (Yu & Kilduff, 2019), and dual-strategies theory suggests that humans navigate these hierarchies through the use of dominance (force and coercion) or prestige (display of valued traits to gain respect; Maner & Case, 2016). In...
A variety of human diseases and pregnancy related disorders reflect endometrial dysfunction. However, rodent models do not share fundamental biological processes with the human endometrium, such as cyclic menstruation, and no existing human cell cultures recapitulate the cyclic interactions between endometrial stromal and epithelial compartments necessary for decidualization and implantation....
“Queer Correspondence: Form and Femininity in the Long Eighteenth Century” interrogates the role that the epistolary form played in the construction, representation, and discipline of female gender expressions and sexualities across the eighteenth century. Working from the perspectives of queer theory, formal analysis, and literary history, this dissertation argues that...
Given directives such as the UN Global Goals targeting sustainable development, the research presented herein makes but a small contribution to the advancement of alternative energy technologies. Nevertheless, the present work was largely motivated to address specific points of intrigue within the thermoelectrics community. The general principles demonstrated, however, may...
Total synthesis of natural products provides an avenue for investigation of complex chemical scaffolds, not only delivering access to biologically impactful molecules but also lending a deeper understanding of their inherent chemical reactivity. Expansion of reaction methodology, optimization of biological activity, and absolute structural confirmation can all be accomplished via...
In this thesis, we study applications of the theory of perverse sheaves and their enhancements to problems in birational geometry. In the first application, we give positive results towards a conjecture of Batyrev about the nonnegativity of stringy Hodge numbers. In particular, we prove the nonnegativity of $(p,1)$-stringy Hodge numbers...
Cells are often precisely organized into patterns within developing tissues. This precision must emerge from biochemical processes within, and between cells, that are inherently stochastic. I investigated the impact of stochastic gene expression on self-organized pattern formation, focusing on Senseless (Sens), a key target of Wnt and Notch signaling during...
The variation of entropy in a family of dynamical systems is a natural indication of the bifurcations that the family undergoes. In the context of one-dimensional dynamics, Milnor's monotonicity of entropy conjecture (now a theorem of Bruin and van Strien) asserts that for polynomial interval maps with real critical points...
Phenotypic diversity underlies life as we know it–a variety of species, each with different roles, are essential for a fully functioning ecosystem just as a range of different crops is necessary to provide different nutritional value. Even within a single species, individual variation promotes diversity, allowing for adaptation to new...
Approximately 80-90% of individuals with Parkinson’s disease (PD) develop motor speech impairments, predominantly in the form of voice dysfunction. It is known that the motor symptoms of PD arise from degeneration of the dopamine producing neurons in the substantia nigra and dysregulation of basal ganglia motor pathways. It is also...
Soft matter is the field of science concerning soft and deformable materials: such as liquids, gels, and foams. Active matter is a sub-field of soft matter that considers systems that contain active agents or particles that consume energy for self-propulsion or to exert mechanical stress on the surrounding system. In...
In conventional data federations, a set of data providers each possess an autonomous database and collectively make the union of these databases available for querying by a client from a unified SQL interface. This setting however, provides no guarantees on data privacy or security. With my work, I consider a...
After the Second World War, two states claimed to represent the same nation: “China.” This work examines how the Kuomintang (KMT) and the Communist Party of China (CPC) competed to represent China and the international consequences of that competition. The CPC’s victory in the Chinese Civil War (1946-1949) led to...
With connected vehicle generated (CVG) information, traffic stream parameters become straightforwardly quantifiable, enabling traffic state characterization and examination over a variety of operational conditions. Since the observation is independent of any spatial restrictions and unaffected by queue buildup and discharge, CVG data offer more comprehensive, more reliable inputs to the...
This dissertation studies three aspects of health insurance market regulation and design. Chapter 1 (which is joint work with Steve Cicala and Ethan Leiber) studies a regulatory mechanism used to constrain insurer market power. The mechanism targets health insurers' Medical Loss Ratio, which is the share of premiums spent on...
Using social network analysis and legal, regulatory, and policy-based case studies, this dissertation explores the ways information and communication technologies (ICT) are regulated internationally. First, it details the composition of the interorganizational, cross sector network, describing the member and governance bodies active in ICT standard setting organizations (SSOs) and the...
This dissertation asks how researchers can create more equitable algorithmic systems. Ultimately, this thesis explores methods and implications of representing subjects of analysis in the design and evaluation of algorithmic systems. I also unpack how algorithmic tools measure and quantify human behavior, giving heed to the potential impacts of these...
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we used dynamic metabolic labeling with stable isotopes followed by proteomic...
This dissertation addresses questions in the fields of household finance and corporate finance. In Chapter 1, I use a quasi-experiment in Norway to examine how households respond to capital taxation. The introduction of a new wealth assessment methodology in 2010 led to geographic discontinuities in household exposure to wealth taxes,...
In the short amount of time that genetic manipulation has been possible through CRISPR technology, myriad applications have been developed. Results from one of the most promising applications of this technology, pooled screens, have shown that single guide RNAs (sgRNAs), RNA sequences used to target specific regions of the genome,...
Background: Cancer-related cognitive impairment (CRCI) is among the most frequently reported adverse events during and following cancer treatment. Between 17% to 75% of chemotherapy-treated cancer patients evidence long-term cognitive deficits as many as 20 years after treatment. The variability in prevalence and the mechanisms of persistent CRCI are not well...
This dissertation is a contribution to the depth and breadth of prison media history. I position prison media of the 1970s as key antecedents to the prison reality television of the 2000s and today. The purpose of this arrangement is to bring attention to an era of prison media that...
Organic chromophores show great promise for energy and optoelectronic devices, due to their synthetic tunability and low production costs. In order to achieve this potential, their fundamental photophysical processes must be better understood. It has long been documented that chromophore packing at the molecular level has dramatic effect on electronic...
The philosophical literature on modals is dominated by the following paradigm: modals are modeled as quantifiers over sets of possible worlds. The diversity of modal “fla- vors” (e.g., epistemic, deontic, teleological interpretations of modals) is accommodated within the paradigm by logical mechanisms that allow extralinguistic factors to restrict the quantificational...
There is a paradox at the center of twenty-first century American poverty. On the one hand, American poverty seems to have become an object of significant interest (at least to scholars and to the reading public)—as evidenced through the surge of wildly successful non-fiction books about poverty. On the other...
I analyze a new mechanism through which changes in aggregate income can result in changes in the labor income distribution. This mechanism arises from heterogeneity in the expenditure elasticity of different sectors and in their employment composition. Once total income increases the mechanism suggests that consumption will be re-allocated towards...
Computational imaging (CI) is a class of imaging systems that optimize both the opto-electronic hardware and computing software to achieve task-specific improvements. Machine/deep learning models have proven effective in drawing statistical priors from adequate datasets. Yet when designing computational models for CI problems, physics-based models derived from the image formation...
An extensive set of functional electronic properties depends on the electronic structure. These properties are directly connected to the reciprocal-space representation of electronic structure. However, there is a complementary, real-space perspective that is described by combinations of atomic orbitals. Atomic orbitals are the components of electronic structures, analogous to how...
Cyclodextrin-based polymers (CDPs) are adsorbents based on supramolecular receptor chemistry and have emerged as a promising technology for organic micropollutant remediation. Micropollutants are small organic molecules which contaminate water systems from human related activities. The occurrence of micropollutants in water sources is associated with many negative health, economic, and ecological...
This dissertation describes the study of photoinduced charge transfer between QDs and molecular acceptors as a probe of the defects within ligand shells of QDs and as means to photocatalyze redox reactions. For charge transfer reactions to occur between QDs and molecules in bulk solution, the molecules must interact with...
This dissertation explores mid-twentieth century US stand-up comedy recordings and how they elaborate upon definitions of the avant-garde in theatre and performance studies. Weaving theories of comedy, aesthetics, radical performance, and sound studies, I argue for the reconceptualization of the avant-garde as an intellectual impulse outside of the parameters of...
Difficulties in prosody (e.g., intonation, volume, rate), turn-taking, and overly formal speech constitute common social communication deficits in autism spectrum disorder (ASD), which can significantly hinder social interactions (Paul et al., 2009). Subtle parallel differences in social communication have also been noted in parents of individuals with ASD, suggesting that...
This dissertation examines the impact of sound on the African literary imagination since the 1970s. I posit the sonority of postcolonial African writing in order to draw out the relatively ignored but remarkably rich stylistic innovations and political interventions oriented around sound. While the orality–textuality debate in African literary studies...
Perhaps because of the influence of the central limit theorem, it is common for scientists to assume distributions in the real world are singly peaked and unimodal. However, many quantities in nature are actually better represented by multimodal distributions. One must provide an explanation for this disconnect between the central...
In this dissertation we study the connections over principal bundles in dimension four with bounded Yang-Mills energy, and present a new result on the existence a global Coulomb gauge with estimate in optimal space. To be precise, let $A$ be a $W^{1,2}$-connection on a principal $\text{SU}(2)$-bundle $P$ over a smooth...
Autonomous trucks (ATs) are envisioned to potentially revolutionize the logistics sector. The integration of autonomous trucks into the overall truck fleet will impact industry regulations and ease driver-related challenges. It also has the potential to improve road safety and reduce carrier costs. There is an extensive body of literature on...
This multi-study dissertation explores experiences of music education for students with disabilities with a particular focus on students with autism spectrum disorder (ASD). It is comprised of three distinct papers including two qualitative studies and a literature review. In the first study, I collaborated with Dr. Sarah J. Bartolome to...
Interfacial effects play a critical role in perturbing the properties of polymeric materials. The average properties of polymer materials with substantial specific interfacial area, e.g., ultrathin films, nanorods, and polymer nanocomposites, often deviate significantly from the bulk responses. Much of the past research has focused on systems in which free...
Volunteer-based physical crowdsourcing systems connect individuals to make unique contributions to solve local and communal problems and enable new services. A key challenge in enabling such systems is attracting enough willing volunteers who can make useful contributions to achieve desired system goals. While most volunteer-based systems provide volunteers flexibility to...
A fundamental understanding of the photophysics involved in solar energy capture and conversion is crucial to the development of carbon-neutral energy technologies. Taking inspiration from nature, the photosynthetic reaction center (PSRC) is often modeled by simpler versions of its elements to allow for better control over the system and for...
Structural colors originate from the interaction between the incident light and a surface with periodic submicron structures. They enable the creation of a spectrum of nonfading colors, potentially replacing toxic metal oxides and conjugated organic pigments. However, significant challenges remain, including lack of contrast needed for the complete gamut of...
Algorithmically-driven social platforms present a challenge for self-presentation and identity management by obscuring audiences behind algorithmic mechanisms. Users are increasingly aware of this and actively adapting through folk theorization, but we do not know how users are coping with the constant change endemic to these platforms. We also do not...
In this thesis we study two problems, one in unsupervised learning - k-means clustering and the other in a supervised learning setting with the presence of adversarial perturbations. We do a beyond-worst case style analysis and show that in either case instances that are resilient to adversarial perturbations are also...
Hypnaesthesis argues for understanding somnambulism, nightmare, and insomnia as aesthetic categories in the gothic and dark romantic traditions of antebellum American literature that provide critical insights into the experiential costs of the exhortations to normative vigilance prevalent in the American Enlightenment. During this period unceasing vigilance became the watchword for...
“Open Tables: Restaurants and Reform in Progressive Chicago” considers restaurants as contentious spaces where larger debates about gender, class, race and ethnicity, public health, and the role of the state were carried out between the end of the Civil War and the ratification of the 18th Amendment. Using Chicago as...
Conceptually, we can divide this dissertation into Chapter 1 which is in the tradition of information economics and comparative statics, and Chapters 2 to 4 which had all its genesis in the same project concerning identifying the value of product differentiation to consumers with minimal assumptions, and is therefore related...
There is strong evidence for the benefits of teaching parents of toddlers with autism spectrum disorder (ASD) intervention strategies for facilitating language development. A strategy at the core of early parent-mediated interventions for ASD is responsiveness, defined as providing a child with a verbal response each time she communicates. Responsiveness...
This dissertation addresses three distinct topics in development economics. The first chapter assesses the role of entry and exit in the measurement of misallocation in India. In the last decade, misallocation of productive inputs across firms has been proposed as a primary driver of differences in aggregate productivity over time...
Western scientific norms (e.g., Bacon, 1623/2005) dictate that mechanistic explanations like “rain falls because clouds form water vapor” are preferable to teleological ones like “rain falls so that plants should grow. Do people have preferences that naturally align with this? The predominant interpretation of past research is that they do...
Commonsense inference is a critical capability of modern artificial intelligence (AI) systems. The machines need commonsense knowledge to perform tasks exactly like human being does. Learning commonsense inference from text has been a long standing challenge in the field of natural language processing due to reporting bias -- people do...
How do perceivers stereotype people who are at the margins of multiple, interlocking social identities? The present dissertation proposes and tests a model of intersectional stereotyping called intersectional categorization theory (ICT). This model advocates the following core ideas: (a) that perceivers use one lens at a time for making sense...
Uttering Sonic Dominicanidad: Women and Queer Performers of Música Urbana Verónica Dávila Ellis What meanings are ascribed to the voices and sonic compositions of Caribbean and Latinx women and queer performers? What do their sounds tell us about Caribbean identity, gender, sexuality, and race? This dissertation centers the work of...
With the global rise of surveillance technology, contentious episodes may be captured on video from multiple perspectives. These perspectives include the third-person visual perspective such as red-light cameras and dashboard cameras, the first-person visual perspective such as body-worn cameras, and perspectives from written descriptions such as police reports and witness...
Reading informs our understandings of the world. Information we encounter in both academic and everyday reading situations can be integrated into our general knowledge, influencing our perceptions and decisions. When the information we read is valid, these influences are desirable. However, we are also routinely exposed to inaccurate information which,...
This dissertation studies the sense most neglected in literary studies, philosophy, and the history of the senses: olfaction. It argues that modernity has been marked by a tendency towards deodorization that attempts to establish a monosensorial and odorless civilization shaped by ocularcentrism. Against this tendency, the authors studied here (Friedrich...
There is a rich history on the study of the interplay between symmetry and synchronization in networks. At the most fundamental level, many synchronization patterns are induced by underlying network symmetries. However, when stability is taken into account, the relation between symmetry and synchronization is far from monotonic. In this...
Current genetic studies are largely biased towards European populations, leaving the discovery of genomics biomarkers and causative genetic variants unexplored in minority populations, such as African Americans. Meanwhile, African Americans are disproportionately affected by a variety of complex diseases and respond differently to many drug treatments. The disparity is due...
Mobile internet has brought a disruptive innovation to the ride-hail industry. The technology introduced by Uber, referred to as e-hail, matches passengers with drivers through their smart phones, while integrating transaction and feedback in a single app. In comparison to taxis hailed off street, or street-hail (s-hail hereafter), e-hail has...
In everyday conversations, listeners need to rapidly perceive and parse speech input as they receive it. While listeners with normal hearing may do this with relative ease, this is a multi-step process that requires listeners to recognize individual speech sounds as meaningful then integrate them to understand and respond almost...
Scholars of early-twentieth-century Buenos Aires—an international theatre hub— disproportionately emphasize Spanish-language performances. This tendency erases the histories of immigrant performing artists, such as Yiddish-speaking Jews who fled en masse to Argentina in order to escape rising antisemitism in Europe and Russia. By focusing on Yiddish theatre in Buenos Aires, this...
Information policies are an effective way to alleviate information asymmetries, but the effectiveness of such policies depends critically on the underlying incentives people face. This dissertation is comprised of three papers that study the welfare effects of various information policies using game-theoretic models. The first paper analyzes how networks of...
Iron is an essential nutrient and is critical for cellular growth and metabolism. Here, we delineate a novel mechanism by which iron alters amino acid homeostasis and mTOR activity by remodeling the cellular epigenetic landscape. We find that iron deficiency inactivates Jumonji-C domain containing histone-demethylases, resulting in histone hyper-methylation and...
Modern design practices rely more and more on computer simulations due to their low cost compared with physical experiments. However, it is still an elusive task to fully unleash the advantages of the simulation models while mitigating their disadvantages for designing complex engineering systems. In simulation-based design, computer simulation models...
This thesis contains three chapters studying the evolution of the American higher education landscape, the different forces that shaped their organization, and how they, in turn, influenced human capital accumulation. The chapters are organized into three time periods: 1850-1900, 1910-1940, and 1980-2010. In the first chapter, joint with Heyu Xiong,...
In this dissertation I examine how the government should respond to sovereign risk and show that it has implications on the optimal behavior of the government. In Chapter 1, I look into international reserve management. In Chapter 2, I analyze the effects of sovereign risk on the size of fiscal...
ABSTRACTUnderstanding Micro-macroscopic Phenomena of Tribological Fluids and Surfaces
Mechanical power and motion are transmitted through interfaces under contact and relative motion. Friction is inevitable, which can lead to higher operating and energy costs, and severe frictional rubbing can result in material damage and cessation of motion. A deep understanding of...
The work presented in this thesis is aimed at developing surface coatings for two specific applications: 1) the self-cleaning surfaces and 2) fouling control in water filtration membranes. Since all materials interact with their environment through their surfaces, tailoring surface properties by implementing surface coatings can greatly affect their performances...
This project uses the political and environmental history of maquiladoras—duty-free assembly plants along the U.S.-Mexico border—to offer new insights into two pivotal moments in the history of the U.S political economy: the poverty eradication plans of Lyndon Johnson’s Great Society and the neoliberal growth models of the late twentieth century....
A series of theories and models are developed and used to investigate the growth of protective oxide films on metal and alloy surfaces for cases in which Wagner's classical model of oxidation does not hold. First, irreversible thermodynamics is applied to formulate a model for the outward growth of rocksalt...
Unmournable Void: Tending-Toward the Dead and Dying in Contemporary Black Performance and Visual Art, explores critical artistic practices that tend to the historical conditions of anti-black violence resulting from transatlantic slavery, colonialism, and apartheid. This triad of regimes produced the Black condition as the unmournable void lived in close proximity...
The Quincke effect is an electrohydrodynamic instability which gives rise to a torque on a dielectric particle in a uniform DC electric field. Previous studies reported that a sphere initially resting on the electrode rolls with steady velocity. In this thesis I report the experimental discovery of another regime, where...
Fluorescence microscopy has become a widely used tool in many research areas. However, its spatial resolution, limited to 250 nm by the diffraction limit of light, has restricted direct observation of details of ultrastructural biology. In recent years, spectroscopic single-molecule localization microscopy (sSMLM), one of super-resolution imaging techniques, has been...
Robots can be capable partners when interacting with humans, but their value is largely dependent on how information is communicated in that partnership. In physical human-robot interaction, information is communicated via motion---configurations, velocities, forces, and torques. The autonomy interprets these implicit signals using metrics, which ultimately drive the the autonomy....
The need to rapidly develop and produce life-saving vaccines and therapeutics is critical for overcoming pandemics in a global economy. Recent advances in automation and cell-free systems have opened new avenues for expediting optimization and production of biologic vaccines and therapeutics. A key consideration for the development of protein biologics...
Pseudomonas aeruginosa is an important gram-negative opportunistic pathogen whose large genome allows it to thrive in diverse environments. There is a wide range of phenotypic variation within the species, which can be attributed both to variation in sequences present in most isolates (the core genome) or the presence or absence...
This thesis presents methods to improve the manipulation capabilities of robots. People and animals can effectively handle objects of many shapes, sizes, weights, and materials using a variety of manipulation primitives such as grasping, pushing, sliding, tipping, rolling, and throwing. In contrast, most robots manipulate objects by pick-and-place. Restricting robots...
Sequential batches of time-evolving data for a set of persistent identifiable entities (e.g. online shopping behavior by month for a customer ID, or economic figures by year for a collection of countries) can exhibit temporal shifts in their underlying clustering structure. Methods for recovering this evolutionary clustering structure exploit natural...
The protein homeostasis (proteostasis) network, a critical cytoprotective system that restores homeostasis in response to molecular stress, comprises distinct pathways, including the heat-shock response, unfolded protein response, oxidative stress response, and autophagy. These distinct pathways are all co-opted by tumor cells to cope with cancer-associated stress, and their activation in...
Over the past 15 years, there have been significant developments in expanding the singlet fission (SF) library and understanding the SF mechanism. SF has been a topic of interest in recent years due to its potential applications in organic photovoltaics. During SF, a singlet exciton energetically down-converts into two triplet...
Part I: Design of Photo-Responsive Molecules towards Biomedical ApplicationsThe use of light to control systems provides numerous advantages such as spatiotemporal precision, non-invasive penetration, and precise energy input. Specifically, molecules that undergo photoinduced cleavage, photoremovable protecting groups (PPGs) have emerged as an active area of research due to their broad...
The pp → W + W − process is important as it allows the test of electroweak theory. Mea-surements of this processes have lead to reduced uncertainties on many other processes one
of which being the Higgs. There have been discrepancies between predicted and measured
cross-section values for pp →...
ABSTRACT Genome Mining in Actinobacteria via a Hybrid-Omics Discovery Platform James Hudson Tryon Natural products isolated from Actinobacteria are a vital source of medicines, agrochemicals, and commodity chemicals. The traditional, activity-driven fractionation pipelines that provided access to many of these natural products have delivered diminishing returns in recent decades. However,...
This thesis studies inter vivos transfers in twenty European countries during the years 2004 to 2017. Inter vivos transfers are transfers made during the lifetime of the donor and the donee. They participate in the intergenerational transmission of inequality and they are an expression of familial values of solidarity and...
The hippocampus has a well-established role in episodic memory and serves as a hub in a network of distributed brain regions (i.e., hippocampal-cortical network; HCN). Theta-band (4-8 Hz) neural activity recorded in the hippocampus have been associated with memory processing, and synchronized theta oscillations among the hippocampus and HCN regions...
Plasminogen activator inhibitor-1 (PAI-1) is an essential mediator of senescence and a potential therapeutic target for preventing aging-related pathologies. Cellular Senescence is associated with organismal aging and related pathologies. In our study, we investigate the efficacies of PAI-1 inhibitors in both in vitro and in vivo models of homocysteine...
South Africa’s rates of mental, neurological, and substance use disorders are among the highest in sub-Saharan Africa. In 2016, the estimated 12-month prevalence for any psychiatric disorder was 16.2%, or approximately 9.1 million individuals. Despite these elevated rates of psychiatric morbidity, access to mental health treatment is poor: only 27%...
A significant portion of material science research is concerned with understanding theway that defects affect the properties materials. In the field of thermoelectrics introducingor removing point (0D), dislocation (1D), grain boundary (2D), or precipitate (3D) defectsare popular methods for altering a materials thermoelectric efficiency. Herein I discussdifferent studies conducted during...