In this thesis we study the geometric limits under degree growth of Julia sets and filled Julia sets for complex polynomials with a unique critical point at $z = 0$. Specifically, for $c \in \mathbb{S}^1$, we are interested in the limit of the associated sequence of Julia sets $J(f_{n,c})$ in...
Digitization has led to dramatic cost reductions and reshaped both what and how products are sold. This dissertation examines the impact of digitization on the behavior of market intermediaries that bring together producers and consumers. Our empirical context is the transition from 35mm film to digital cinema technologies in the...
Inflammasomes are intracellular multiprotein signaling complexes that link Pathogen Associated and Danger Associated Molecular Patterns (PAMPs and DAMPs) by Pattern Recognition Receptors (PRRs) to the activation of Caspase-1, leading to the secretion of pro-inflammatory cytokines interleukin (IL)-1β and IL-18, and the induction of pyroptosis. Nucleotide-binding oligomerization domain (NOD)-like containing a...
The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is implicated in active transcription. Here we show that DOT1L is overexpressed in Prostate cancer (PCa) and is associated with poor clinical outcome. Genetic and chemical inhibition of DOT1L selectively impaired viability of androgen receptor (AR)-signaling competent PCa...
The integration of field-programmable gate arrays (FPGAs) into large scale computing systems is gaining attention. In these systems, real-time data handling for networking, tasks for scientific computing, and machine learning can be executed with customized datapaths on reconfigurable fabric within heterogeneous compute nodes. At the same time, high-level synthesis (HLS)...
Wearable visual systems, such as ego-centric wearable cameras, have failed to integrate into everyday life. We have witnessed the abandonment of wearable visual systems as consumer devices (e.g., Google Glass) and as research tools (e.g., SenseCam). While it is natural for some technologies to die out, visual wearable systems are...
Multistage optimization is a prominent modeling tool to solve a broad range of dynamic decision-making problems in the presence of uncertainty. However, computing optimal policies is intractable, since they are obtained by considering all possible realizations of uncertainties and subsequent future decisions over time. To overcome these challenges, we present...
Thinkers attempting to challenge existing conceptions of political life often find that they encounter limitations in dominant modes of spectatorship and communication. If popular audiences are unsuitably oriented toward the presentation of certain content, this introduces a fundamental obstacle for political theoretic efforts to shape ideas and interactions. This dissertation...
Listeners can experience strong and often positive identification with music. Contemporary research has emphasized the importance of a listener’s own identity, including their sense of self and their desires, when forming such identifications. However, acknowledgments of the listener’s role in the listening experience have failed to productively engage discussions of...
Chemical modifications of oligonucleotides (ONs) have advanced these molecules towards clinical approvals. On their own, native ONs have poor pharmacokinetic properties, such as rapid degradation by nucleases and poor cell uptake, which limit their potential therapeutic applications. Chemical modifications of ONs can increase their stability, alter their interactions with cells,...