Molecular self-assembly is a process in which molecules spontaneously form ordered aggregates, the process of which is important in the natural world, considering those ordered systems and complex architectures contained in a living cell. The goal of chemists is to design simple molecules or chemical systems that can undergo molecular...
Biochips and high-throughput screening methods are powerful tools for studying biological processes. The combination of peptide arrays and SAMDI mass spectrometry incorporates these tools to study a broad range of biochemical transformations, including enzyme activities, to provide valuable information on substrate recognition and guide the development of diagnostic and therapeutic...
Plant life history traits influence the extent and degree of gene flow across a species range. The resulting genetic neighborhood size can influence population differentiation and the scale of local adaptation, with implications for species response to environmental change and sourcing of plant materials for ecological restoration. To assess the...
The Gramm-Rudman-Hollings Act (or “GRH”), which unprecedentedly provided for “sequestration”, a doomsday device to enforce fiscal discipline upon Congress and the President, was passed with bipartisan support on December 12, 1985. How did GRH take place, and why did it assume its final form? Casting GRH’s enactment in functionalist and...
The invention of GdIII-based magnetic resonance imaging (MRI) probes substantially expanded the capability of MRI in visualizing details in tissue. Building upon the achievement of GdIII-based complexes, more ideal probes should feature contrast that is responsive to biomarkers, such as redox status and ion concentrations. The abnormality of these biomarkers...
In response to exponentially increasing demand for digital media, today's Internet landscape has evolved into a multitude of diverse and interdependent distribution systems designed to move content as efficiently as possible. While many of these systems have \emph{individually} been explored in depth by both academic and industrial communities, a cross-sectional...
To relate the mechanical responses of hard-soft copolymer systems with their microstructures, a coarse-grained molecular dynamics (CGMD) approach is employed. With the generic bead-spring polymer model mapped from atomistic simulations, this dissertation first studies the morphology of structures with various hard-soft compositions and interactions between hard beads. Following that, this...
The start of the 21st century brought the sweeping proliferation of portable electronics such as laptops, tablets, and smartphones. These technologies were largely enabled by advances in energy storage methods – lithium ion batteries in particular. Society's push for more advanced energy storage applications, such as electric vehicles, stresses the...
This dissertation explores Holocene climate change along the west coast of Greenland and late Holocene climate variability in the subpolar North Atlantic region using paleolimnology. Lake sediment archives and the climate proxies contained within them provide a valuable window into past temperature change on Greenland, home to one of Earth’s...
Assistive robotics focuses on human-robot systems that provide physical support and assistance to the elderly and people with motor-impairments. While assistive machines, such as the powered wheelchair, can significantly enhance the functional independence of individuals, many users are challenged by their direct operation, the manner in which such systems are...
ABSTRACT Variation of stateness across the territory and population of sovereign states is a notorious, but understudied phenomenon with important implications for issues such as global security, environmental sustainability, and political stability. This dissertation engages in theory-building research to explain subnational variation of stateness in the contemporary world, focusing on...
This dissertation adopts a jointly ethnographic and historical approach to study shifting racial formations and configurations of inequality in the metropolitan U.S. South. Specifically, it analyzes how immigrants and working poor populations are reshaping the social life, privatized spaces, and conservative politics of Atlanta’s white suburbs. It focuses on Sandy...
Citizen media literacy is essential in a democratic society, particularly in the online environment where valid media sources have proliferated alongside purveyors of fake news. This dissertation explores technologies that automatically detect aspects of bias in news articles, with the ultimate aim of leveraging them to augment media literacy. It...
In the design of efficient adsorbents for the sequestration of toxic molecules and the separation of volatile organic compounds, two important criteria are: high porosity and high density of sorptive sites. The work in this thesis showcases how metal-organic frameworks (MOFs) can be used as porous adsorbent templates where many...
Quantum metrology has been among the most vigorous branches of quantum technology. It involves using quantum effects to achieve better estimation of parameters of a physical sys- tem. Conventionally the system consists of an ensemble of N non-interacting atoms and the measurements are done on individual atomic states, such as...
People and horses have a deep, co-constructed, and co-evolutionary history. This dissertation evaluates sociopolitical change of the Hungarian Bronze Age (2800 – 800 BC) in the context of long-term shifts in human-horse relationships. In the Bronze Age, horses are assumed to mount the development of complex polities ruled by elite,...
This dissertation studies topics in health care operations management related to value-based care, where {\em value} can be thought of as the ratio of quality to cost. The objective in value-based care is to increase, or maximize, value by reducing costs and improving quality health outcomes. In Chapter 1 we...
This dissertation is a broad study on individual and firm-level financial conditions and their effects on politics. In the first chapter, I study the effect of economic conditions on political polarization using micro-data on house prices, mortgages, and individual political contributions. I argue that shocks to housing wealth --- the...
The world is an increasingly interdependent place. Regions of economic activity are deeply connected with each other through the movement of goods, labor and ideas. This has deep consequence for both the economist and policymaker: in the evaluation of economic activity, an exogenous shock in any given region does not...
Macrophages are one of the most versatile immune cells in the immune system. They are found in nearly every tissue and organ throughout the body. Macrophages play important roles of orchestrating initiation and resolution of inflammation, such as sentineling against pathogens or engulfing apoptotic cells. Macrophages are able to respond...
In December 1889, a few weeks after the monarchy in Brazil was replaced by a republican government, seventy-year-old USAmerican poet Walt Whitman wrote a poem called “A Christmas Greeting” to welcome the “Brazilian brother” into democracy. Though filled with hope and excitement for yet another republic born in the Americas,...
Proteins are a class of nanoscale building block with remarkable chemical complexity and sophistication: their diverse functions, shapes and symmetry, and atomically monodisperse structures far surpass the range of nanoparticles that can be accessed synthetically. The chemical topology of proteins that drive their assembly into higher order materials are central...
Innovations are adopted by individuals and spread to other individuals. They are adopted at different rates, some are never adopted at all, some are abandoned, and some become the new norms. A very extensive evidence-based research and practice paradigm that studies how innovations spread is called diffusion of innovations. This...
During the 1870s and 1880s, state governments in the former slaveholding South established eleven public institutions for black higher learning. Given the volatile, impoverished, often repressive climate of the region, how did black political and educational leaders mobilize to expand state support for black higher education? Furthermore, how did they...
Cardiac Magnetic Resonance (CMR) is a promising non-invasive imaging technique capable of assessing cardiovascular function and anatomy for both adult and pediatric patients without the need for ionization energy. Even with the stated benefits, CMR utilization in the clinic is low (~1-2%) due in large part to long acquisition time...
Recent studies have shown that many high profile studies in biology could not be reproduced, calling into questions the legitimacy of their findings. These reports have the potential to greatly jeopardize the credibility of scientists in the field as well as erode public confidence in the scientific enterprise. Computational research...
Historically, there have been large disparities in the degree to which different communities have access to resources and representation within society. With the increased availability of the internet and the growth of user-generated content platforms like Twitter and Wikipedia, there are opportunities to alleviate some these long-standing barriers to access...
Promyelocytic leukemia (PML) nuclear bodies act as quality control centers in the nucleus, participating in a plethora of nuclear functions. As such, PML bodies are a signature model for functional nuclear organization. PML bodies have a dynamic protein composition that responds to changing conditions of the cell. Many of the...
Neisseria gonorrhoeae (Ng), a strict human pathogen, is the sole causative agent of gonorrhea. Gc possess a complex gene conversion system, the pilin antigenic variation system, (pilin Av), which alters the DNA sequence of the major pilin, PilE. Pilin Av results in the constant alteration of the surface exposed appendage,...
Chapter 1 presents analysis comparing the effectiveness of two mechanisms of regulation enforcement: (1) the frequency of inspections and (2) penalties for violations. Recent policy changes regarding enforcement of mining safety regulations are exploited to quantify the effectiveness of each mechanism. It is concluded that increasing the frequency of inspections...
Thinkers attempting to challenge existing conceptions of political life often find that they encounter limitations in dominant modes of spectatorship and communication. If popular audiences are unsuitably oriented toward the presentation of certain content, this introduces a fundamental obstacle for political theoretic efforts to shape ideas and interactions. This dissertation...
Mortgage brokers originate a large share of residential real estate lending. Exploiting state-level regulatory changes to local entry costs I am able to study the effect on credit quality and access. Using data from a major mortgage lender in the run up to the financial crisis I study how the...
The purpose of this multiple-case study was to examine the lived experiences of current collegiate music education majors, both students from under-represented minorities and their well-represented peers, with attention to racial/ethnic identity and social class. Dyads of current music education students at 8 separate colleges/universities—a student from an under-represented racial...
Two-dimensional (2D) materials are a promising class of electronic materials that have generated great interest to improve and create new and existing technologies. The promise of this family of materials relies on their high surface-to-volume ratio and atomic thickness in addition to their unique (opto)electric properties. However, these morphological properties...
Synthesis opens the pathway to examine a plethora of complex structures. Whether the target is a naturally occurring compound or a proposed molecule never observed before, synthetic routes can be developed to help understand a variety of properties that the molecule can contain. Synthetic efforts have helped elucidate the absolute...
If I mistakenly hear you ask for directions to the “shore” when instead you asked for directions to the “store,” the miscommunication is probably an innocent mistake. If, on the other hand, a man misunderstands a woman’s refusal of his sexual advances as consent, the mistake seems like it might...
This dissertation explores an intellectual and political tradition that questioned the use of natural resources and the socioeconomic structures of rural Brazil in the early 20th century. “Organicist agrarianism” postulated an orderly transformation of the Brazil under the guidance of the state in the name of a natural and eternal...
Recent advances in combinatorial chemistry, synthetic biology, and ‘omics’ research require high-throughput methods for performing and analyzing thousands to millions of reactions in one day. However, it is a challenge to engineer high-throughput systems that can autonomously conduct and analyze such a large number of reactions in a generalizable and...
We perform many movements every day without much deliberation. However, moving can be seen as a form of decision-making since one of many possible movements must be selected and executed. The decision-making processes that underlie movements are influenced by various factors, including sensory perception, energetics, time, perceived rates of failure...
At the turn of the twentieth century, the Russian Orthodox Church established a dense network of social and material aid for thousands of migrants who travelled from the Russian and Austro-Hungarian Empires to find work in the United States. The church’s growth followed the path of Progressive Era industrialization, with...
In the United States and around the world, the growing energy demands and climate concerns necessitate renewable and efficient energy production. Thermoelectric materials could be one small part of this larger picture movement, but their high cost and low efficiency must be improved to realize commercial use. To decrease the...
The US yogurt market has been volatile in the last decade, marked by striking sales increases and dramatic market structure changes. According to an industry report, dollar sales of yogurt in 2017 reached $8.8 billion---a more than 80% increase from 2007. Such remarkable sales growth can be attributed to the...
This thesis forcuses on the development of the transition-edge sensor (TES) for various X-ray science applications, especially for synchrotron beamline experiments. The ultimate aim is to build a detector that has a higher energy resolution than semiconductor detectors, and a higher operation speed than crystal spectrometers. The possible applications include...
Histamine is a well-known potent mediator during the elicitation of IgE-mediated allergic diseases. The most robust, and potentially fatal, response of histamine is observed in patients with food allergy that undergo IgE-mediated anaphylaxis. The key mechanisms of the biology of histamine in allergic disease are well-established, however there are still...
Problems in interpersonal functioning are a major concern. In adults, interpersonal dysfunction is often investigated as it relates to personality disorders (PDs). In fact, researchers have argued that a core of interpersonal dysfunction is what defines personality disorders (Hopwood, Wright, Ansell, & Pincus, 2013). This is perhaps most evident for...
This dissertation explains the heterogeneous effects of armed conflict on sub-national governance in the North Caucasus. While acknowledging the role of inherited institutions, my multimethod investigation shows how they were strategically transformed during the breakup of the Soviet Union, creating unintended consequences and the basis for governance today. My main...
Nonlinear systems with many interacting components often exhibit behaviors that cannot be anticipated, even in principle, by only knowing the properties of the constituent parts and thereby emerge as a result of interactions between the parts. Examples of such systems range from power grids and financial markets to food networks...
The literature has established glucokinase (GCK) to be the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. We have recently proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1...
Identifying key molecular mechanisms and targets for therapeutic development in sporadic neurodegenerative diseases has been challenging. Therefore, in-depth investigation of genetic forms of disease can provide valuable insight into pathogenic disease mechanisms. The discovery of genetic forms of Parkinson’s disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative...
Public memory studies in rhetoric have typically neglected how we use shared memories to form, maintain, and pass down social norms through the objects we encounter and the practices we participate in during our everyday lives. This is especially true for children’s toys, because they are understood as essential objects...
Recent studies have begun to examine white matter connectivity aberrations in psychiatric populations, such as major depressive disorder. Several studies have found reduced white matter integrity (WMI) in depressed samples, though the location of this reduction is not clear. Incorporating symptom measures of depression severity and rumination may allow for...
New neurons are continuously produced in the subgranular zone of the dentate gyrus of the hippocampus throughout life. These newborn dentate granule cells (DGCs) undergo a stereotyped process of morphological and functional maturation during the first few weeks after differentiation that recapitulates some aspects of postnatal neuronal development. The inhibitory...
Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
Biological tubes are essential for animal survival, and their functions are highly dependent on tube shape. Analyzing the contributions of cell shape and organization to the morphogenesis of small tubes has been hampered by the limitations of existing programs in quantifying cell geometry on highly curved tubular surfaces and calculating...
The presence of unwanted biofilms on surfaces is a great concern for industrial, naval, and healthcare fields, and many other settings. To better inhibit, remove, or harness the properties of biofilms, an explanation of how specific structural or chemical features of biofilm matrix components leads to enhanced adhesion and persistence...
Flowing granular mixtures with species differing in some property, such as size, shape or density of the grains, tend to segregate (de-mix) during flow. Since flowing granular materials are common in industry, and since segregation is often unwanted and costly, understanding and mitigating segregation is an important concern in industrial...
This dissertation is a history of religious conservatism between 1880 and the onset of the Great Depression in 1929. Its main argument is that conservative religion in America, rather than being defined by fundamentalism, theological disputes, or cultural antipathy towards pluralism, was an outgrowth of a profound faith in capitalism...
The analytical paradigm in philosophy has as a pillar an analysis of the sentence as a basic entity. New sentences may be built from old sentences recursively through the application of logical constants, recently including intensional operators. Models are built on how these logical constants interact with each other, and...
Soft materials such as colloids and polymers often exhibit a variety of mesoscopic structures that are governed merely by weak physical interactions. Due to these intermediate structures, they can be easily taken out of thermal equilibrium by introducing external stimuli such as a shear flow and electromagnetic fields. This thesis...
While Li-ion batteries are currently the preferred energy storage technology, multivalent alternatives such as Mg should be considered. Magnesium metal has a high volumetric capacity and has been shown to cycle with no dendrite formation. However, the highly charged Mg2+ ion cannot easily diffuse into the oxide cathodes favored in...
This project traces the efforts by Scottish Protestants to achieve complete religious uniformity in the decades following the Reformation. Discontented with outward conformity, the via media that long characterized our understanding of religious reform in England, Scotland’s ministers sought to work genuine conversions among those who resisted the new order....
One of the grand challenges in science is development of soft materials that mimic living organisms to optimize the way we use energy, translate or morph reversibly or sense their envi- ronment and respond in a useful fashion. Using the insights from studying biological structures, we hope to design soft...
In this dissertation I study the effects of mortgage leverage policies. These policies have become widely used in recent years, both as a macroprudential tool and to protect consumers, yet their effects are still not well understood. In Chapter 1, I show that mortgage leverage rules implemented under the Dodd-Frank...
Deep neural networks have shown impressive performance for many applications. In this dissertation, leveraging the capabilities of neural networks for modeling the non-linearity exists in the data, we propose several models that can project data into a low dimensional, discriminative, and smooth manifold. The suggested models can transfer knowledge from...
This dissertation studies three distinct problems in econometrics. Chapter 1 proposes an adaptive randomization procedure for two-stage randomized controlled trials. The method uses data from a first-wave experiment in order to determine how to stratify in a second wave of the experiment, where the objective is to minimize the variance...
The cerebellum is involved in sensorimotor processing and motor control in the brain. What has been found across many species for many behaviors is cerebellar Purkinje (Pkj) cells and cerebellar nuclear (CbN) cells show activity that is related to and predictive of movements. Less is known about how patterns of...
Many human diseases are chronic and ultimately fatal because they damage organs and tissues beyond the body’s normal repair mechanisms. Therefore, there is significant medical interest in developing pharmaceuticals that enhance the body’s natural injury repair mechanisms and engineering organs in the lab for transplantation. However, comparatively little is known...
The emerging paradigm of quantum information science (QIS) vows to transform a wide range of fields, such as computation, communication, and sensing. The fundamental unit at the core of any QIS system is a quantum bit, or qubit. Rather than be restricted to one of two classical states (0 or...
As the global population grows, consumption of water, energy, and food will also increase, placing stresses on these sectors, raising the importance of the Water-Energy-Food Nexus (WEFN). However, operation of WEFN systems are currently not sustainable. It is thus crucial to design WEFN systems to be sustainable from local to...
This dissertation consists of three essays on corporate governance. In the first essay of the dissertation (“The Effects of Succession Planning on CEO Succession Events: Implications for Both Focal and Competing Firms”), I examine whether and how both focal and competing firms are affected by sudden CEO deaths. By using...
This dissertation examines how the maintenance and adaptation of heritage monuments and ritual traditions have contributed to the sustainability of communities on the islands of Inishark and Inishbofin along the west coast of Ireland. My analysis combines archaeological investigation of a pilgrimage tradition on Inishark, from its origins in the...
For women, age is one of the best predictors of fertility. Younger women are typically more fertile, and ability to conceive declines until a woman reaches menopause. However, the age at which an individual woman becomes less fertile varies depending on many factors unique to her individual body, including genetic...
This dissertation explores two factors that affect innovation. The first factor studied is extrinsic, namely, the legal environment. The second factor is a factor of input into innovation - culture of the inventors. The first chapter studies the impact of a weakened patent environment on research investments. Departing from the...
Location awareness will be crucial for many future wireless network applications, such as the Internet of Things (IoT) and vehicular networks. In particular, the IoT will connect a massive number of new devices to wireless networks. Localization solutions that work in urban environments and have solutions which scale well with...
This dissertation argues that the U.S.’s World War I experience helped condition Americans to relate to war primarily through cinematic recreations. The country’s geographical distance from the fighting provided Americans a degree of geopolitical spectatorship from which they could imagine their nation’s role in an ever-changing world through film. Onto...
This thesis contains results in mathematical quantum ergodicity in a probabilistic or a complex analytic setting. For the former, we show that a random orthonormal basis of spherical harmonics is almost surely quantum ergodic, in which the randomness is induced by the generalized Wigner ensemble. For the latter, we show...
In mature neurons, postsynaptic NMDARs are segregated into two populations, synaptic and extrasynaptic NMDARs, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR content (NMDAR-plasticity). Here, we identify the phosphorylation of the PDZ-ligand of...
Students pursue educational and career future identities (e.g., graduating college, becoming an engineer, etc.) that are tied to their deepest wants, desires, and needs, yet many find it difficult to exert self-control and resist temptations while pursuing these identities (e.g., studying versus watching TV, paying attention in class versus scrolling...
Judiciary at the Crossroads argues that a professional judiciary was able to restrain power, and thus lay the foundation for an independent judiciary and possible the rule of law later. Historical evidence comes from the performance of courts in property ordering projects launched by the governments in Taiwan and Manchuria...
Polycystic ovary syndrome (PCOS) is among the most common endocrine disorders of premenopausal women, affecting 5-15% of this population depending on the diagnostic criteria applied. It is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. PCOS is highly heritable, but only a small proportion of this heritability can be...
This dissertation takes up Islam’s relationship to Black nationalism across the Atlantic diaspora of Muslims that I call “the Fugitive Islamicate.” Scholars most often have described this relationship as commencing in the twentieth century with the rise of “Black Muslim religion,” a U.S. religious movement that begins with Noble Drew...
This dissertation is composed of three articles that focus on the electoral support coalitions of populist parties in Latin America. Using typologies, comparative-historical analysis, and experimental methods, the articles conceptualize and explain variation across several dimensions of these coalitions: their size and scope, their level of organization, and the identities...
Many species of rodents rely on the set of exquisitely sensitive facial vibrissae (whiskers) to guide rich behaviors in which other senses are inadequate. Although whiskers are, like all hairs, inert strands of keratin, they provide the animal with a rich landscape of tactile information which is used to guide...
Magnetic resonance imaging is a powerful research tool for studying anatomical processes in intact large organisms, as it is capable of generating high resolution images with unlimited penetration depth and excellent soft-tissue contrast. However one of the challenges faced by those seeking to use the technique to answer biochemical questions,...
Reducing the high incidence of metabolic syndrome especially among older people living in low income communities is a goal of the health system. Residents of the Austin community of Chicago suffer from a heavy burden of health issues related to metabolic syndrome leading to disproportionally higher morbidity and mortality rates...
The problem of theological normativity concerns the conflict between the purported eternal, universal, and ahistorical nature of Christian theological and ethical claims and the fact that such claims are always articulated in a particular time and place and, therefore, seem to bear the marks of cultural and historical contingency. My...
This dissertation explores the role and relation of capitalism in contemporary political life, with the aim to reveal the inherent oppression of what I refer to as capitalist culture. To this end, the project follows three main objectives: (1) to identify the widespread and pervasive nature of capitalist culture (2)...
Ultrafine particles are often used as lubricant additives because they can enter tribological contacts to reduce friction and protect surfaces from wear. They tend to be more stable than molecular additives under high thermal and mechanical stresses during rubbing. However, in lubricant oil, ultrafine particles tend to aggregate together to...
Franz Rosenzweig’s The Star of Redemption ranks as one of the most original and innovative works of the modern period. Thinkers as diverse as Buber, Benjamin, Levinas, Strauss and Derrida have all acknowledged its influence. Yet, there has not been any consensus on the book’s main objective or agenda. Some...
Polymers permeate almost all facets of modern life. For end use applications, these materials are typically processed into products at elevated temperatures under which molten polymers are subjected to flow. Particular interest lies in the flow-induced crystallization behavior of polymer melts under extensional flow, which is a flow type dominant...
This thesis consists of three projects, centered around the aim to better model real-world systems under uncertainty, specifically, under stochastic disruptions, using optimization. A stochastic disruption is a type of infrequent event in which the timing and the magnitude are random. We introduce the concept of stochastic disruptions and a...
Contactin associated protein like 2 (CNTNAP2) has emerged as a prominent susceptibility gene implicated in multiple complex neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability (ID), and schizophrenia (SCZ). The presence of seizure comorbidity in many of these cases, as well as inhibitory neuron dysfunction in Cntnap2 knockout (KO)...
Understanding how spin waves propagate through ferromagnets is an important component of a wider international effort to create spintronic devices. In this thesis, we develop a propagating spin wave spectroscopy to make a variety of measurements on thin films of Yttrium Iron Garnet (YIG), a material known for having long...
In this dissertation, I cover three different topics in macroeconomics. In Chapter 1, I explore the macroeconomic implications of an increase in business competition and its micro transmission channels. In Chapter 2, I document a rise in savings and cash holdings by non-financial corporations across advanced economies and show that...
The concealed information test (CIT) has garnered more empirical support than other methods of recognition detection and has a firm theoretical foundation. Because it occurs involuntarily, even when recognition is denied, P300 amplitude is a robust indictor of concealed information. Although the P300-based CIT shows great promise for field use,...
The tension-spoke bicycle wheel owes its stiffness and strength to a cooperative relationship between the rim and the spokes: the rim holds the spokes in tension to prevent them from buckling under external loads, while the spokes channel external forces to the hub and prevent the rim from becoming severely...
The structure of the North American crust and mantle was investigated using P wave teleseismic tomography and the links between seismic tomographic models, locations of volcanism, sediment isopachs, and continental scale crustal structures via plate reconstruction modeling. Nearly 50,000 teleseismic P wave delay times were measured from seismograms recorded by...
Infidel(itie)s of Colour: Unruly Black Bodies, Modernity and Performance in Post-Apartheid South Africa focusses on the ways that queer and feminist artists of colour draw upon their traditional black cultural heritage and spiritual practises as a means of laying claim to cultural citizenship and belonging in post-apartheid South Africa. I...
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated Cas proteins provide an immune-like response in many prokaryotes against extraneous nucleic acids. CRISPR-Cas systems are classified into different classes and types that vary widely in composition, target recognition, and overall mechanism. The main division of CRISPR-Cas systems occurs between...
The focus of this thesis is on evaluating, designing, and applying statistical methods that elucidate molecular mechanisms by seeking to understand the pathways that contribute to disease. Chapter 1 introduces the field and motivates the work in this thesis. Chapters 2, 3, and 4 describe original work. Chapter 5 recapitulates...