Spinal cord injury causes devastating and frequently irreversible loss of neurological function. Although injured central nervous system neurons have the intrinsic ability to regenerate, the environment in the damaged spinal cord is non-permissive. The goal of this thesis was to explore the cellular and molecular mechanisms that limit recovery after...
Substance abuse is one of the most critical public health problems affecting juvenile detainees. Previous research suggests that a significant proportion of juvenile detainees with substance use disorders do not receive treatment prior to or during detention. Using data from the Northwestern Juvenile Project, a large-scale longitudinal study of juvenile...
Embedded systems are ubiquitous. Although many aspects of embedded system design and synthesis have received significant research attention, comparatively less attention has been given to new ideas in memory hierarchy design. This dissertation presents several new operating system and architecture techniques that use elements of the virtual and physical memory...
All forces applied to the human hand are transmitted through the arm to the trunk. Hence, the arm represents an important mechanical interface between the trunk and the environment. By regulating this interface in a task-appropriate manner, humans are able to interact with a wide range of tools and objects,...
The III-Nitride material system has already proven to be commercially viable for blue light emitting diodes (LEDs), blue laser diodes (LDs), and near UV photodetectors. Continued interest in this field has driven the desire for even lower emission and detection cut-off wavelengths into the solar-blind / deep UV portion of...
In the first part of the dissertation, I investigate the nature of retail coupons, a popular tool for non-price competition. The widely expressed view that coupons are primarily a tool to allow price discrimination has received mixed empirical supports. I depart from the static framework of the price discrimination theory...
We first introduce the concept of copulas and advocate its use for multivariate option pricing. We focus on four types of bivariate options: basket, rainbow-max, rainbow-min, and spread options. We derive expressions for these options as a function of the copula. We then construct pricing bounds for these bivariate options...
The T-box transcription factor, Tbx5, is involved in heart development and congenital disease. For example mutations in human TBX5 lead to Holt-Oram syndrome, a disease characterized by a range of heart and arm malformations. Tbx5 gene activity has been perturbed in several animal models including the chicken, mouse, and zebrafish....
Most organisms use rhythms of sunlight to synchronize their activity to the environment. These rhythms of activity are called circadian rhythms. The rhythms persist with near 24 hour periods when external synchronizing cues are absent. In mammals, the circadian clock is generated at the molecular level by a transcriptional/translational feedback...
This thesis contributes in two ways. First it describes a new framework for the systematic design of collective behaviors and solves a key stability issue under this design framework. In this thesis we apply this framework to solve three tasks in the swarm robotics field: connectivity maintenance, formation control and...