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-
- Description:
- Carbon nanotubes (CNTs) have exceptional properties and are mass-producible at the ton scale as aggregated powders, but their difficulty in processing is a significant barrier to widespread use. Even after decades of research, there still isn’t a solvent for CNTs that is massively available, easily removable, and non-damaging. The need...
- Keyword:
- Cresol and Carbon Nanotube
- Subject:
- Nanoscience
- Creator:
- Chiou, Kevin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_742961 and http://dissertations.umi.com/northwestern:15105
-
- Description:
- Transcriptome profiling including whole genome bulk and single cell RNA sequencing (RNA-seq) enables the quantitative study of transcript changes at either tissue or single cell level. With the advancement in next generation sequencing technology, it is now part of routine lab practice. More than other high-throughput technologies, computational algorithms are...
- Keyword:
- single cell RNA-seq, RNA-seq, and Clustering algorithm
- Subject:
- Bioinformatics
- Creator:
- Ren, Ziyou
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15101 and etdadmin_upload_742881
-
- Description:
- This thesis contains three chapters studying macroeconomics and trade. The chapters are organized into two topics: inflation expectations and perceptions, and the effect of trade intermediation on economic activity. In the first chapter, I investigate whether households are significantly harmed by inaccurate beliefs about inflation. The chapter analyzes two established...
- Keyword:
- Entrepot, Surveys, Inflation Perceptions, Interest Rates, and Savings Behavior
- Subject:
- Economics
- Creator:
- Montag, Hugh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15109 and etdadmin_upload_743158
-
- Description:
- Uterine leiomyomas (fibroids) are a major source of gynaecologic morbidity in reproductive age women and are characterised by the excessive deposition of a disorganised extracellular matrix, resulting in rigid benign tumours. Clinically, leiomyoma patients usually present with pelvic pain, urinary incontinence, as well as heavy cyclic and non-cyclic bleeding. Curative...
- Subject:
- Molecular biology, Bioinformatics, and Biology
- Creator:
- Moyo, Mthabisi Bongani
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_723828 and http://dissertations.umi.com/northwestern:15028
-
- Description:
- Across the United States, public school districts are facing critical budget crises. To keep cuts away from the classroom, bus transportation is a common area to look for cost reductions. This thesis studies two fundamental problems that arise in public school transportation: the bus route design problem and the school...
- Subject:
- Operations research
- Creator:
- Zeng, Liwei
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15120 and etdadmin_upload_743801
-
- Description:
- Early-stage oxidation and corrosion mechanisms of CoCrMo and NiCrMo alloys can be analyzed on the nanoscale by transmission electron microscopy. Both alloys are attractive for a broad array of applications such gas turbines and aircraft engine components as they are known for their excellent corrosion resistance and mechanical properties at...
- Keyword:
- CoCrMo, Applied sciences, Electron microscopy, Corrosion, Oxidation, and Tribology
- Subject:
- Materials Science and Engineering
- Creator:
- Lin, Alex Yu-Wei
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15082 and etdadmin_upload_741813
-
- Description:
- The engineering of human reproduction is one of the defining scientific advances of the past century. Methods to specifically engineer the testis have an equally long and rich history, and have experienced significant progress over the past two decades, leading to current-day breakthroughs which are shifting the paradigms by which...
- Keyword:
- testis, model, organoid, reproduction, microenvironment, and explant
- Subject:
- Bioengineering, Biology, and Endocrinology
- Creator:
- Edmonds, Maxwell Ethan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_743728 and http://dissertations.umi.com/northwestern:15119
-
- Description:
- The groups that we identify with help to make us who we are. This dissertation investigates the impact of the way that each of us understands those identities, through the newly introduced construct of collective self-concept clarity (Gardner & Garr-Schultz, 2017). Two aspects of collective self-concept clarity are introduced and...
- Keyword:
- intragroup motivation, collective self-concept clarity, authenticity, intergroup bias, well-being, and identity
- Subject:
- Social psychology and Psychology
- Creator:
- Garr-Schultz, Alexandra
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15100 and etdadmin_upload_742713
-
- Description:
- Background: Glioblastoma (GBM) tumors are the most malignant brain cancers and are characterized as Grade IV astrocytomas by the World Health Organization. GBM tumors can be classified into three molecular subtypes known as proneural, classical, and mesenchymal. In addition, GBM tumors also have a small population of cells known as...
- Keyword:
- LY6K, Methylation, Glioblastoma, ERK1/2, and CAV-1
- Subject:
- Molecular biology, Oncology, and Neurosciences
- Creator:
- Sastry, Namratha G
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_733180 and http://dissertations.umi.com/northwestern:15049
-
- Description:
- In 2018, our ATRAP collaboration produced 5 trapped antihydrogen atoms per hour long trial. An apparatus with a Ioffe octupole trap and a faster magnet dump was used to confine and detect trapped antihydrogen atoms. This apparatus is unique in that four sideports spaced at 90 degrees from each other...
- Subject:
- Physics
- Creator:
- Nottet, Edouard
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_730096 and http://dissertations.umi.com/northwestern:15037
-
- Description:
- Recent decades have seen fan and “geek” culture become widely popular as the science fiction, fantasy, and superhero stories that used to be the preserve of a smaller subculture of die-hard fans conquered the box office, our televisions, and the best-seller lists. In that same time period, the Internet has...
- Keyword:
- fan entitlement, fandom, and fan culture
- Subject:
- Rhetoric and Communication
- Creator:
- Kaudel, Donna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15054 and etdadmin_upload_736093
-
- Description:
- Romantic and sexual relationships are an integral part of human development, with implications for emotional, social, and physical well-being across the lifespan. However, what, when, and how we teach young people remain pertinent questions. Using a combination of interview data from 24 recent high-school graduates and survey data from a...
- Keyword:
- Sexual Coercion, Adolescence, Consent, and Romantic Relationships
- Subject:
- Sexuality, Developmental psychology, and Education
- Creator:
- Thomas, Sara Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15102 and etdadmin_upload_742921
-
- Description:
- Ataxic dysarthria is a disorder affecting the naturalness of speech due to damage to the cerebellum, a neural structure critical for the timing, scaling, and sequencing of speech movements (Ackermann, Vogel, Petersen, & Poremba, 1992; Diener & Dichgans, 1992; Duffy, 2013; Rampello, Rampello, Patti, & Zappia, 2016). In healthy individuals,...
- Keyword:
- Ataxia, Auditory Feedback, Pitch-shift, Dysarthria, Prosody, and Pitch
- Subject:
- Speech therapy, Linguistics, and Acoustics
- Creator:
- Hilger, Allison Ilice
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15086 and etdadmin_upload_742085
-
- Description:
- Recent encouraging advances in computer vision and natural language understanding shed light on a very interesting yet challenging task: asking and answering questions about a given image (VQA). The study of this research problem is still in its infancy. Most existing VQA methods are neural network-based (NN-based) solutions that pursue...
- Keyword:
- visual relation detection, graph matching, computer vision, and visual question answering
- Subject:
- Electrical engineering
- Creator:
- ZHAN, HUAYI
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15097 and etdadmin_upload_742604
-
- Description:
- With more jobs in science, technology, engineering, and math (STEM) fields available than people to fill them, the United States is extremely focused on increasing STEM education to address this gap in the future workforce. This focus is not exclusive to higher education and secondary schooling, but rather, it has...
- Keyword:
- preschoolers, learning, haptics, STEM, tablets, and Tanvas
- Subject:
- Early childhood education and Mass communication
- Creator:
- Pila, Sarah
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_738851 and http://dissertations.umi.com/northwestern:15061
-
- Description:
- The planarian flatworm Schmidtea mediterranea is capable of recovery from nearly any injury, including regenerating an entire brain after decapitation, made possible by a pool of pluripotent stem cells which maintain all of the worm’s tissues into adulthood. However, the signals that control the production of new neurons in these...
- Keyword:
- Neurogenesis, Planaria, Regeneration, Stem cells, and Tec Kinase
- Subject:
- Biology
- Creator:
- Karge, Alexander
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15021 and etdadmin_upload_720401
-
- Description:
- Many theories of categorization have included an intuitive role for our ability to detect and judge similarity. Yet, this important role of similarity processing has been disputed. This research adopts a model of similarity processing through structure mapping (Gentner, 1983) to explore its role in similarity processing and categorization. Relational...
- Keyword:
- psychology, cognition, language, categorization, analogy, comparison, logic, fallacies
- Subject:
- Cognitive psychology
- Creator:
- Francisco Maravilla
- Contributor:
- Dedre Gentner (advisor)
- Owner:
- Francisco Epimeno Maravilla
- Language:
- English
- Date Uploaded:
- 08/07/2020
- Date Modified:
- 08/07/2020
- Resource Type:
- Dissertation
-
- Description:
- This dissertation examines the behavior of bare singular noun phrases, a set of English nominals showing no formal indication of either definiteness or mass/ count status. Although they appear to be count nouns, I show that these nominals represent maximal projections.
- Keyword:
- semantics, noun phrases, activity implicature, familiarity implicature, and maximal projections
- Subject:
- Linguistics
- Creator:
- Laurel Smith Stvan
- Owner:
- Chris Diaz
- Date Uploaded:
- 06/12/2020
- Date Modified:
- 06/12/2020
- Date Created:
- 1998
- Resource Type:
- Dissertation
-
- Description:
- This paper examines the vocal works of Pelle Gudmundsen-Holmgreen in an effort to establish that, despite their technical difficulty and apparent complexity, these pieces are actually rooted in the Danish New Simplicity (Ny Enkelhed) aesthetic. It also provides biographical, historical, and cultural context for those who are interested in performing...
- Keyword:
- music, new simplicity, denmark, gudmundsen, choral, danish, pelle , and holmgreen
- Subject:
- Music
- Creator:
- A.J. Keller
- Owner:
- Andrew Jason Keller
- Date Uploaded:
- 05/19/2020
- Date Modified:
- 05/19/2020
- Date Created:
- 2020-05-19
- Resource Type:
- Dissertation
-
- Description:
- Hollow biopsy needles are widely adopted medical devices for the removal of biological tissue to better identify a lesion or an abnormality observed through a physical exam or a radiology scan. These procedures can provide significantly more information than most medical tests, and they are usually performed on dermis layers,...
- Keyword:
- micro-serration, needle rotation, needle insertion, helical needles, tissue cutting, and core biopsy
- Subject:
- Mechanical engineering
- Creator:
- Giovannini, Marco
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14984 and etdadmin_upload_717405
-
- Description:
- Low-dimensional materials have emerged as a promising platform for ultrathin electronic and optoelectronic devices. The span of electronic properties covers the spectrum from metallic through small and medium bandgap semiconductors to large bandgap insulators, providing all the necessary components to fabricate a variety of devices. Compared to bulk-semiconductor based devices,...
- Keyword:
- Gaussian, self-aligned, spiking neuron, antiambipolar, low-dimensional materials, and van der Waals heterojunction
- Subject:
- Applied physics, Electrical engineering, and Materials Science
- Creator:
- Beck, Megan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14986 and etdadmin_upload_717678
-
- Description:
- The active participation of external entities in the design and manufacturing flow has produced numerous hardware security issues. Among all the hardware security problems, piracy and overproduction are likely to be the most ubiquitous and expensive ones. Most leading-edge design houses have outsourced their fabrication to the offshore foundries for...
- Keyword:
- Hardware Security, Circuit Obfuscation, Logic Encryption, and Logic Locking
- Subject:
- Computer engineering
- Creator:
- Rezaei, Amin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718743 and http://dissertations.umi.com/northwestern:15000
-
- Description:
- The goal of the work reported here was to answer two important questions with regards to LTVV use for patients with ARDS: 1) How do we measure adoption? and 2) What are the drivers of provider adoption? To this end, I have demonstrated the influence of patient height, hypoxemia severity,...
- Keyword:
- data science, low tidal volume ventilation, network science, implementation science, and acute respiratory distress syndrome
- Subject:
- Biomedical engineering and Medicine
- Creator:
- Bechel, Meagan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14975 and etdadmin_upload_716010
-
- Description:
- Researchers and educators have argued that productive learning may occur when young people have freedom to organize their activity based on their own interests and concerns. Schools increasingly provide “makerspaces” that allow students to design and build objects and technical devices of their choosing, and researchers have developed in-school programs...
- Subject:
- Education
- Creator:
- Meyerhoff, Peter
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15005 and etdadmin_upload_719129
-
- Description:
- This dissertation studies three topics in 19th and early 20th century economic history. Chapter 1 studies the causes behind low inter-regional migration from the American North to the South prior to the Civil War. Chapters 2 and 3 focus on topics in the economic history of Egyptian agriculture. Chapter 2...
- Keyword:
- Migration, Civil War, Technology Adoption, Cash Crops, Cotton, and Egypt
- Subject:
- Economic history
- Creator:
- Daubenspeck, Jamie Mark
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_717976 and http://dissertations.umi.com/northwestern:14988
-
- Description:
- Animals must establish the correct form during development. Regeneration is a process by which some animals reestablish their form following injury. This process requires both the generation of new missing cells after injury, and information to pattern new cells to reestablish the correct form. Planarian flatworms have an almost unlimited...
- Keyword:
- planaria, Regeneration, size control, neoblasts, stem cells, and scaling
- Subject:
- Molecular biology and Developmental biology
- Creator:
- Schad, Erik Gregory
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14973 and etdadmin_upload_715415
-
- Description:
- Techniques for achieving complete quantum control over atoms have been developed and perfected over the past four decades with great success. This work has led to multiple Nobel prizes and has been the catalyst for rapid advances in a broad array of research fields. A natural progression forward is to...
- Keyword:
- laser cooling, quantum state control, Ion traps, and SiO+
- Subject:
- Molecular physics, Quantum physics, and Atomic physics
- Creator:
- Stollenwerk, Patrick R
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718268 and http://dissertations.umi.com/northwestern:14994
-
- Description:
- The ribosome, the cell’s machine for synthesizing proteins, can be thought of as the chef of the cell. Just as a chef reads a recipe and combines ingredients to create a dish, the ribosome reads cellular instructions and connects building block molecules (amino acids) to construct proteins. Like the final...
- Keyword:
- Ribosome, Engineering, and PTC
- Subject:
- Biology
- Creator:
- d'Aquino, Anne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_713825 and http://dissertations.umi.com/northwestern:14967
-
- Description:
- Chapter 1: Telomerase is a ribonucleoprotein enzyme that counteracts the shortening of telomeres by catalyzing the addition of nucleotides to the 3’ ends of chromosomes, resulting in telomerase inhibition attracting interest as a strategy for cancer. Telomerase has also been implicated in other tumorigenic pathways such as DNA damage repair,...
- Keyword:
- Natural product-inspired small molecules, Sequential Catalysis, Telomerase, Photoredox, Enzymatic Catalysis, and Cooperative Catalysis
- Subject:
- Organic chemistry
- Creator:
- Betori, Richard C
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14978 and etdadmin_upload_716438
-
- Description:
- Foreign currency debt has led to many crises in emerging markets. In the past decade, firms in emerging economies have drastically increased their foreign currency borrowing, making them significantly exposed to depreciation shocks. To reduce their exposure to external shocks, central banks have increased their use of regulation, such as...
- Subject:
- Finance
- Creator:
- Keller, Lorena
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14972 and etdadmin_upload_715245
-
- Description:
- Superalloys strengthened by γ′(L12)-precipitates in γ(f.c.c.)-matrix exhibit superior high temperature mechanical properties and environmental resistance over long periods of operation, making them ideal candidates for aerospace and energy conversion applications. The emerging class of superalloys based on Co-Al-W ternary system was identified with a melting temperature 50-100 ˚C higher than...
- Keyword:
- Microstructural evolution, Co-based superalloys, Atom-probe tomography, Phase-field, Mechanical properties, and Creep
- Subject:
- Materials Science
- Creator:
- Chung, Ding-Wen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_717986 and http://dissertations.umi.com/northwestern:14989
-
- Description:
- Self-Assembled Monolayers for MALDI-TOF Mass Spectrometry (SAMDI-MS) is a technique that combines self-assembling molecules of alkane disulfides on gold and MALDI-TOF mass spectrometry. By using well-defined monolayers with functionalizations that both prevent non-specific adsorption onto the surface and presents immobilization handles, it is possible to pull out analytes of interest,...
- Keyword:
- Peptides, Data Storage, MALDI, and SAMDI
- Subject:
- Chemistry
- Creator:
- Ten, Alexei Sergeevich
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718764 and http://dissertations.umi.com/northwestern:15001
-
- Description:
- During influenza A virus (IAV) infection, severe lung injury and death result from an exuberant host inflammatory response, or “cytokine storm”, orchestrated by pulmonary epithelial cells. The linear ubiquitin assembly complex (LUBAC), composed of SHARPIN, HOIL-1L and HOIP, is a critical regulator of NF-κB-dependent inflammation. To determine the impact of...
- Subject:
- Immunology
- Creator:
- Brazee, Patricia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14980 and etdadmin_upload_716742
-
- Description:
- The importance of concern for others in the lives of emerging adults has been underestimated by emerging adult theory. In this set of studies, I explore emerging adults’ concern for others in the higher education context. I use three different samples, a group of 10 Latino emerging adults working to...
- Keyword:
- Emerging Adults, Social Change, and Higher Education
- Subject:
- Higher education
- Creator:
- Zapata, Claudia Elena
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_714206 and http://dissertations.umi.com/northwestern:14969
-
- Description:
- Atrial fibrillation (AF) is the most common arrhythmia in adults in the United States. Despite its prevalence, the etiology of AF and its adverse effects are not completely understood, which has made treatment of AF difficult. However, left atrial (LA) fibrosis is associated with worsening and propagating AF. Additionally, research...
- Subject:
- Biomedical engineering
- Creator:
- Gunasekaran, Suvai
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14983 and etdadmin_upload_717382
-
- Description:
- The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is implicated in active transcription. Here we show that DOT1L is overexpressed in Prostate cancer (PCa) and is associated with poor clinical outcome. Genetic and chemical inhibition of DOT1L selectively impaired viability of androgen receptor (AR)-signaling competent PCa...
- Keyword:
- Prostate Cancer, DOT1L, and Epigenetics
- Subject:
- Molecular biology and Oncology
- Creator:
- Vatapalli, Rajita
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14971 and etdadmin_upload_714534
-
- Description:
- This work is composed of two separate projects that contribute to the field’s understanding of Neisseria gonorrhoeae genetics and physiology. First, I showed that N. gonorrhoeae mounts a substantial transcriptional program in response to hydrogen peroxide (HP), a prominent reactive oxygen species (ROS) encountered during infection. We measured which strain...
- Keyword:
- Bacterial genetics, Microbiology, Neisseria gonorrhoeae, and Bacteriology
- Subject:
- Microbiology
- Creator:
- Quillin, Sarah Jane
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14977 and etdadmin_upload_716337
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- Description:
- The continued existence and use of chemical warfare agents (CWAs) have necessitated the development of materials which can safely and efficiently decontaminate these toxic chemicals in an environmentally benign fashion. Among the most prevalent CWAs, nerve agents (sarin, VX) and blistering agents (sulfur mustard [HD]) are considered the most toxic...
- Keyword:
- polyoxometalate, chemical warfare agent, oxidation catalysis, and metal-organic framework
- Subject:
- Inorganic chemistry
- Creator:
- Buru, Cassandra Terez
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15003 and etdadmin_upload_718951
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- Description:
- The viscoelastic properties of microbial biofilms have attracted great interests in recent years due to the ubiquity of biofilms and their wide range of industrial and municipal applications causing tremendous societal impacts. Biofilms are predominantly architected by extracellular polymeric substances (EPS) matrices composed of bacterial cells and biopolymers secreted by...
- Keyword:
- Rheology, Optical coherence elastography (OCE), Nondestructive testing, Viscoelastic properties, Biofilms, and Wave propagation
- Subject:
- Environmental engineering, Mechanical engineering, and Acoustics
- Creator:
- Liou, Hong-Cin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_714259 and http://dissertations.umi.com/northwestern:14970
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- Description:
- In this dissertation, we study models and methods to address uncertainties that can vary in optimization problems. Robust optimization is a popular approach for optimization under uncertainty, especially if limited information is available about the distribution of the uncertainty. It models the uncertainty through sets and finds a robust optimal...
- Keyword:
- variable uncertainty, optimization, decision dependent uncertainty, and robust optimization
- Subject:
- Industrial engineering and Operations research
- Creator:
- Sharma, Kartikey
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718511 and http://dissertations.umi.com/northwestern:14998
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- Description:
- Nucleic acid drugs promise to revolutionize the development of therapeutics. They offer a platform for digital medicine, where systematic changes to the nucleic acid sequence can be utilized to target the entire human genome. However, nucleic acids suffer from a number of drawbacks, such as negligible cellular uptake and rapid...
- Keyword:
- siRNA, Spherical Nucleic Acids, and High Throughput Analysis
- Subject:
- Nanotechnology, Nanoscience, and Biochemistry
- Creator:
- Yamankurt, Gokay
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14982 and etdadmin_upload_717353
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- Description:
- Mineral inclusions in diamond, brought to the surface through kimberlitic eruptions, provide a unique glimpse into the geochemical inner workings of Earth’s deep interior. Diamonds source a wide range of depths in the mantle. While most diamonds originate from the upper 200 km of the Earth’s mantle, aptly called super-deep...
- Keyword:
- mineral, computed microtomography, diamond, radiography, microdiffraction, and microinclusions
- Subject:
- Geology
- Creator:
- Wenz, Michelle Dawn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_719066 and http://dissertations.umi.com/northwestern:15004
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- Description:
- Episodic memory provides a means by which we reflect on the past, make decisions about the future, and form a learned identity. Episodic memory depends on the hippocampus as well as on the distributed set of regions that form a hippocampal-cortical network (HCN), including medial prefrontal, posterior cingulate, and medial...
- Keyword:
- memory, hippocampus, brain network, and stimulation
- Subject:
- Neurosciences
- Creator:
- Warren, Kristen N
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14985 and etdadmin_upload_717587
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- Description:
- Skeletal muscle is one of the most abundant tissues in the body and makes up over 40% of the total body mass. It is important for mobility and posture maintenance as well as plays a central role in whole body metabolism. Skeletal muscle is made up of bundles of muscle...
- Keyword:
- Muscle plasticity, Genomics, ChIP-seq, and Muscle atrophy
- Subject:
- Molecular biology and Endocrinology
- Creator:
- Ramachandran, Krithika
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718262 and http://dissertations.umi.com/northwestern:14993
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- Description:
- Dilute Al-Sc-Zr-Si-based aluminum alloys retain their strength for long periods of time at elevated temperatures due to a dispersion of nanometric, coherent, and coarsening-resistant Al3(Sc,Zr) (L12 structure) nanoprecipitates that are formed upon aging. These alloys are attractive for replacement of dense steels and costly Ti alloys in the 250–400 °C...
- Keyword:
- L12 nanoprecipitates, Atom-probe tomography, Coarsening, High-temperature alloys, Creep, and Aluminum alloys
- Subject:
- Materials Science
- Creator:
- Michi, Richard Andrew
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718569 and http://dissertations.umi.com/northwestern:14999
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- Description:
- This dissertation examines the birth and rise of orthorexia nervosa, a proposed psychiatric diagnosis described as a pathological fixation with healthy eating. Orthorexia made its first public appearance in the pages of a popular magazine for yoga practitioners in 1997, and later in a self-help book on the subject. Despite...
- Keyword:
- health journalism, media, medicalization, orthorexia, and mediatization
- Subject:
- Mental health, Sociology, and Communication
- Creator:
- Ross Arguedas, Amy A.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_715870 and http://dissertations.umi.com/northwestern:14974
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- Description:
- In susceptible individuals, episodic memories of overwhelmingly stressful experiences can give rise to debilitating socio-affective symptoms, including social dysfunction. This occurs even when such memories are not easily accessed for retrieval. In this case, it is generally accepted that the restricted retrieval of such memories is due to their having...
- Keyword:
- Chemogenetics, Hippocampus, Stress, Dentate gyrus, Social behavior, and Oxytocin
- Subject:
- Neurosciences
- Creator:
- Meyer, Mariah Alexie Azuz
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718313 and http://dissertations.umi.com/northwestern:14995
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- Description:
- The hippocampus has been identified as a critical structure for supporting spatial memory processes in both humans and animals alike. Many of these processes such as the ability to self-localize in a given environment as well as engage in goal-directed navigation are thought to depend on the location-specific firing of...
- Subject:
- Behavioral sciences, Biophysics, and Neurosciences
- Creator:
- Adoff, Michael David
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718033 and http://dissertations.umi.com/northwestern:14990
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- Description:
- Water vapor condenses into liquid water when it encounters a cold surface. If the surface temperature is sufficiently low, freezing follows the condensation step, and the process is holistically referred to as condensation frosting. Both phase change processes are fundamental to many industries ranging from water harvesting, thermal management, solar...
- Keyword:
- Frosting, Condensation, Phase Change, Mass Transport, Diffusion, and Droplet
- Subject:
- Applied physics and Materials Science
- Creator:
- Yao, Yuehan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14997 and etdadmin_upload_718499
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- Description:
- Biogenic secondary organic aerosol (SOA) particles, produced by forest ecosystems across the globe, are principal, yet poorly understood constituents in the climate system. These atmospheric particles form when biogenic volatile organic compounds (BVOCs) react with atmospheric oxidants, leading to increasingly lower volatility oxidation products that partition into the condensed phase...
- Keyword:
- Sum frequency generation (SFG) spectroscopy, Organic synthesis, Cloud condensation nuclei (CCN), Alpha-pinene, Beta-caryophyllene, and Secondary Organic Aerosol
- Subject:
- Organic chemistry, Physical chemistry, and Atmospheric chemistry
- Creator:
- Be, Ariana Gray
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/28/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14957 and etdadmin_upload_710832