In December 1889, a few weeks after the monarchy in Brazil was replaced by a republican government, seventy-year-old USAmerican poet Walt Whitman wrote a poem called “A Christmas Greeting” to welcome the “Brazilian brother” into democracy. Though filled with hope and excitement for yet another republic born in the Americas,...
Proteins are a class of nanoscale building block with remarkable chemical complexity and sophistication: their diverse functions, shapes and symmetry, and atomically monodisperse structures far surpass the range of nanoparticles that can be accessed synthetically. The chemical topology of proteins that drive their assembly into higher order materials are central...
Innovations are adopted by individuals and spread to other individuals. They are adopted at different rates, some are never adopted at all, some are abandoned, and some become the new norms. A very extensive evidence-based research and practice paradigm that studies how innovations spread is called diffusion of innovations. This...
This thesis focuses on exploring the explanatory and discovery potential of the four-neutrino and enhanced neutrino magnetic and electric dipole moments hypotheses when
applied to the NOvA/T2K discrepancy and the XENON1T anomaly, respectively. Firstly,
we study the effect of a very light (sub eV) sterile neutrino on the NOvA/T2K anom-...
The purpose of this thesis is to derive three results in probability theory. The first is a proof that small powers of the normalized absolute characteristic polynomial of a random matrix sampled from either the Gaussian Orthogonal or Symplectic Ensemble converges in law to a Gaussian multiplicative chaos measure. The...
During the 1870s and 1880s, state governments in the former slaveholding South established eleven public institutions for black higher learning. Given the volatile, impoverished, often repressive climate of the region, how did black political and educational leaders mobilize to expand state support for black higher education? Furthermore, how did they...
Cardiac Magnetic Resonance (CMR) is a promising non-invasive imaging technique capable of assessing cardiovascular function and anatomy for both adult and pediatric patients without the need for ionization energy. Even with the stated benefits, CMR utilization in the clinic is low (~1-2%) due in large part to long acquisition time...
Recent studies have shown that many high profile studies in biology could not be reproduced, calling into questions the legitimacy of their findings. These reports have the potential to greatly jeopardize the credibility of scientists in the field as well as erode public confidence in the scientific enterprise. Computational research...
Understanding the outcomes of interactions from assessing shoot traits has practical applications and has elucidated major ecological patterns. Roots and shoots differ in their functions and can differ in responses to abiotic and biotic stimuli. And while roots are more difficult to characterize because they tangle and are embedded in...
Necessity is the mother of innovation. In the wake of the pandemic, with no flow of samples and limited fabrication techniques available, necessity demanded a new material platform and adaptable methods to make complex oxide samples worth measuring. The material platform was KTaO3 , the younger successor to the mainstay...
This manuscript describes and contextualizes the research I performed as a PhD student in Northwestern University. The first three chapters, on Markov chains, stochastic thermodynamics, and large deviation theory, describe three interrelated topics that serve as the background for subsequent research detailed in the next three chapters, on understanding the...
Thermoelectric (TE) materials has been drawn broad attention given that it can enable direct conversion between thermal and electrical energies, hence is treated as a vital candidate for clean power generation as well as waste heat recycling. However, the energy conversion efficiency of TE devices used nowadays is still very...
This dissertation aims to develop innovative analytical methods that integrate engineering, marketing, and social science disciplines to incorporate heterogeneous consumer preferences into product design using network-based customer preference modeling. Both companies and designers frequently face difficulties in understanding and addressing customer preferences, which can result in product failure and loss...
We rely on the properties of our skeletal muscles to traverse our world, interact with objects, and complete everyday tasks. The macroscopic properties of muscles that endow us with these abilities arise from the material properties of muscle fibers and the surrounding extracellular matrix (ECM), as well as how they...
Recommender systems (RSs) have become essential tools that provide personalized recommendations to their users. These systems may consider user, item provider, and system requirements simultaneously. With the inclusion of possibly clashing considerations, there is a growing focus on solving multiple-objective recommender system (MORS) problems as efficiently as possible. The constrained...
Historically, there have been large disparities in the degree to which different communities have access to resources and representation within society. With the increased availability of the internet and the growth of user-generated content platforms like Twitter and Wikipedia, there are opportunities to alleviate some these long-standing barriers to access...
Peptides consists of a series of amino acids connected via an amide type of covalent chemical bond. A diverse field of applications such as biosensors,2 catalysis,4 and biomedicine6 include the oligomeric forms of peptides due to their genuine features comparing to other biomacromolecules. Particularly, peptides in the field of biomedical...
Promyelocytic leukemia (PML) nuclear bodies act as quality control centers in the nucleus, participating in a plethora of nuclear functions. As such, PML bodies are a signature model for functional nuclear organization. PML bodies have a dynamic protein composition that responds to changing conditions of the cell. Many of the...
We establish the criterion for chaos in three-planet systems, for systems similar to those discovered by the Kepler spacecraft. Our main results are as follows: (i) The simplest criterion, which is based on overlapping mean motion resonances (MMRs), only agrees with numerical simulations at a very crude level. (ii) Much...
Machine learning and deep learning have been proven successful across various scientific fields, such as computer vision, natural language processing, and recommendation systems. As models become more complex, with more parameters and intricate architectures, they can achieve higher prediction accuracy when trained on larger datasets. However, despite the great prediction...