In Amyotrophic Lateral Sclerosis (ALS), spinal motoneurons degenerate in the order of large motoneurons that innervate fast and fatigable muscle fibers to small motoneurons that innervate slow muscle fibers (Pun et al. 2006). This order of degeneration is peculiar in that it is in direct opposition to the normal order...
Algorithms which are efficient and robust are essential to meet the increasing computational demands in the world today. In this thesis, we consider the analysis and design of both distributed algorithms for dynamic average consensus and centralized algorithms for convex optimization.
Dynamic average consensus consists of a group of agents,...
3D integration of integrated circuits is becoming a prominent solution in the design of high performance chips. Multiple dies can be stacked in a single 3D structure and utilizes Through Silicon Vias (TSV) for die to die communications. While this feature significantly decrease the latency of data transfer, multi-tier stacking...
Phase separation in segmented polymers provides distinct challenges in regard to their chemical reaction kinetics and characterization. Well studied, it has been shown that structure, phase separation and non-covalent interactions are key factors in the design of elastomeric polyurethanes. Specifically, this dissertation is focused on two areas: the synthesis of...
Ross (2015) proposed a recovery theorem which uses prices of contingent claims to recover market’s expectations about underlying asset returns. His work relies on two assumptions. He assumes all uncertainty of the economy follows a finite state irreducible Markov chain and that the pricing kernel is transition independent. We first...
A failure to effectively regulate emotions elicited by a stressful life event contributes to symptoms of psychopathology. This regulatory failure may result from a deficit in executive control. For some individuals, executive control is impaired following stress exposure. Thus, for some individuals, when executive control is needed to regulate emotions...
SIRT3 is a mitochondrial-localized, NAD+-dependent deacetylase, tumor suppressor protein that functions to direct mitochondrial energy sensing and antioxidant proteins, increasing the efficiency of energy utilization, providing a redox balanced environment, and preventing aging-related diseases. One SIRT3 deacetylation target is NADP+-dependent isocitrate dehydrogenase 2 (IDH2), a key Krebs Cycle enzyme that...
Simulation analytics treats stochastic simulation as data analytics for systems that do not yet exist, and extends traditional performance estimation and system optimization to uncovering underlying patterns and the key drivers and dynamics of system behavior by retaining the sample paths generated throughout simulation runs. My dissertation addresses two research...
This dissertation examines the situated and interactional nature of cultural experiences. Drawing on the literature on materiality, place, and space, the study analyzes how the physical and spatial characteristics of art galleries and art museums in Accra, Ghana, and Johannesburg, South Africa, lead people to engage with culture, and derive...
This dissertation focuses on exploring novel light steering and spectral engineering functionalities by flat optics, which includes photonic architectures of flat plasmonic metasurfaces, nanoparticle arrays, and thin film coatings. We have designed, fabricated and characterized different plasmonic metasurfaces (trapezoid-shaped antennas, nanorings/nanowires, etc.), nanoparticle arrays (single-layered or multilayered nanocubes and nanodisks),...
This dissertation develops a theory of rebel-state engagement during armed conflict that links these varied interactions to processes of institutional change in the state in which they unfold. Conventional wisdom portrays conflict zones as lacking institutions or pitting armed groups and states as competitors. Yet, this dissertation finds that rebels...
Optical quantum communication (QC) has the potential to address the demands of high-speed and maximally-secure communication. In optical QC, information is encoded onto the state of photons. By using entangled photonic states, QC protocols can support fundamentally secure communication for applications which cannot use classical information. To increase the information...
Web users suffer from security and privacy threats. According to Symantec, 430 million new unique pieces of malware have been discovered in 2015, and over half a billion personal records were stolen or lost in the same year. Defense mechanisms can be classified as reactive approach and proactive approach. Reactive...
Over the past two decades, optical coherence tomography (OCT) has been successfully applied to various fields of biomedical researching and clinical studies, including cardiology, urology, dermatology, dentistry, oncology, and most successfully, ophthalmology. This dissertation seeks to extend the current OCT practice, which is still largely morphology-based, into a new dimension,...
In today's marketplace, consumers purchase a basket of goods of different categories from many different types of retail stores. While most marketing literature focuses on studying a single retail chain or a single category, my dissertation considers consumers' collective basket purchases across different retail formats. By doing so, my dissertation...
This dissertation asks how deepening global inequalities reshape the ways families negotiate “economic moralities,” normative expectations of material obligation and entitlement. It focuses on the families of middle class migrants: French-educated Senegalese urbanites whose diplomas no longer protect them from discrimination in Paris but who, among Africans, are still construed...
How do independent artists use social media and e-commerce websites to support their creative businesses? This dissertation examines independent artists’ participation in the peer economy for selling handmade goods, a hybrid economy that combines sharing content on social media and selling goods on e-commerce platforms. While a multidisciplinary array of...
Bacterial gene expression requires numerous steps that are energetically costly and tightly regulated. Following transcription of messenger-RNA, the translation of mRNA into protein is further regulated by a variety of sequence features both within and upstream of coding sequences. Collectively, these features contribute to the control of translation initiation, elongation,...
Seismic waves from large-magnitude earthquakes sometime trigger small secondary earthquakes or tectonic tremor. These secondary signals are important to observe and study because their occurrence reflects on the state of stress of the subsurface, which is important for hazard assessment. Here we first report on how individual inspection by a...
Ecological restoration is vital to the conservation of biodiversity and provision of ecosystem services in a changing world. Biodiversity is often a goal of restoration, and species to be planted for restoration are often selected based on diversity objectives. But species are not independent; they are related to one another...