Index Catalog // Arch : Northwestern University Institutional Repository

Description:: SAMDI-MS, which stands for self-assembled monolayers (SAMs) for matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS), is a powerful tool that has enabled the development of novel high-throughput screening and experimentation methods for decades. SAMDI-MS works by immobilizing analytes to functionalized SAMs prior to MS analysis and is capable of...
Subject:: Bioengineering, Molecular biology, and Biochemistry
Creator:: Pluchinsky, Adam John
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_885633 and http://dissertations.umi.com/northwestern:15968

Description:: Proteins represent a critical class of biomolecules, universally employed by all living organisms to fulfill essential structural, functional, and enzymatic roles necessary to support life. In nature, these polymers are composed generally of twenty natural amino acid (AA) building blocks, which can be modified with covalent adducts known as post-translational...
Keyword:: post-translational modification, genome engineering, cell-free protein synthesis, synthetic biology, orthogonal translation system, and non-canonical amino acid
Subject:: Bioengineering, Biology, and Biochemistry
Creator:: Des Soye, Benjamin James
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14473 and etdadmin_upload_627384

Description:: Breakthroughs in large-scale biological data collection have resulted in a wealth of -omics (genomics, metabolomics, etc.) datasets in the literature. However, the development of appropriate computational techniques for their analysis is lacking, yet crucial for fully extracting the rich information contained in these datasets. The work in this dissertation describes...
Keyword:: Biorecording, Data Storage, Cheminformatics, Metabolomics Annotation, Machine Learning, and TdT
Subject:: Bioengineering, Bioinformatics, and Biochemistry
Creator:: Strutz, Jonathan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_911481 and http://dissertations.umi.com/northwestern:16126

Description:: The work in this thesis focuses on computational methods for the identification of novel enzymatic pathways. In particular this work focuses on the utilization of the Biological Network Integrated Computational Explorer (BNICE) software suite to predict de novo enzymatic pathways for the production of commercially relevant compounds and on improvements...
Subject:: Bioengineering and Biochemistry
Creator:: Stine, Andrew Eugene
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2016-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_614431 and http://dissertations.umi.com/northwestern:14393

Description:: More than half of proteins in humans are modified with carbohydrates in a process called glycosylation, yet this process remains poorly understood even though approximately 1% of the expressed human genome encodes biosynthetic machinery for glycosylation. Unlike genomics and proteomics where high throughput tools are now routinely used to generate...
Keyword:: SAMDI, High-throughput protein synthesis, glycosylation, self-assembled monolayers, glycosyltransferase, and Mass spectrometry
Subject:: Bioengineering, Analytical chemistry, and Biochemistry
Creator:: Techner, Jose-Marc
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14598 and etdadmin_upload_661107

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