Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Cell-based therapies are an exciting frontier in medicine. This field is built on a simple premise—cells can be engineered to recognize and treat various human diseases. The paradigm of cell-based therapy uses biosensors to interrogate a cell’s environment and distinguish disease from health, intracellular signaling pathways and genetic circuitry to...
Keyword:: Cell-based therapy, Synthetic receptors, Synthetic biology, Biosensors, Transcription factors, and Immunotherapy
Subject:: Bioengineering, Biology, and Medicine
Creator:: Donahue, Patrick Sean
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Modified:: 05/06/2022
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15420 and etdadmin_upload_781062

Description:: Over the past fifty years, techniques for synthesizing and manipulating matter on the 1-100 nanometer scale have led to the development of nanoparticle-based approaches to both disease diagnosis and treatment. The modification of nanoparticles with biological macromolecules such as proteins and nucleic acids has led to the development of highly...
Keyword:: Spherical Nucleic Acid, Anthrax, Aptamer, NanoFlare, Gold Nanoparticle, and CRISPR
Subject:: Nanotechnology, Bioengineering, and Biology
Creator:: Larkin, Isaac Nathaniel
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15186 and etdadmin_upload_754966

Description:: The engineering of human reproduction is one of the defining scientific advances of the past century. Methods to specifically engineer the testis have an equally long and rich history, and have experienced significant progress over the past two decades, leading to current-day breakthroughs which are shifting the paradigms by which...
Keyword:: testis, model, organoid, reproduction, microenvironment, and explant
Subject:: Bioengineering, Biology, and Endocrinology
Creator:: Edmonds, Maxwell Ethan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_743728 and http://dissertations.umi.com/northwestern:15119

Description:: Proteins represent a critical class of biomolecules, universally employed by all living organisms to fulfill essential structural, functional, and enzymatic roles necessary to support life. In nature, these polymers are composed generally of twenty natural amino acid (AA) building blocks, which can be modified with covalent adducts known as post-translational...
Keyword:: post-translational modification, genome engineering, cell-free protein synthesis, synthetic biology, orthogonal translation system, and non-canonical amino acid
Subject:: Bioengineering, Biology, and Biochemistry
Creator:: Des Soye, Benjamin James
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14473 and etdadmin_upload_627384

Description:: Platelets are circulating anucleate discs derived from megakaryocytes, and play major roles in hemostasis, inflammation, thrombosis, and vascular biology. Multi-phase culture systems for inducing in vitro platelet production from mature megakaryocytes have been explored to allow progenitor expansion, megakaryocyte maturation, and promotion of platelet formation and shedding. In this thesis,...
Keyword:: gaussian mixture models, stem cell differentiation, machine learning, and megakaryocyte
Subject:: Bioengineering, Bioinformatics, and Biology
Creator:: WU, JIA JIE
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_640286 and http://dissertations.umi.com/northwestern:14541

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