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Description:: In the short amount of time that genetic manipulation has been possible through CRISPR technology, myriad applications have been developed. Results from one of the most promising applications of this technology, pooled screens, have shown that single guide RNAs (sgRNAs), RNA sequences used to target specific regions of the genome,...
Keyword:: sgRNA design, CRISPR efficiency, and Machine learning
Subject:: Biostatistics, Statistics, and Bioinformatics
Creator:: Zarate, Oscar Alberto
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15353 and etdadmin_upload_773909

Description:: The advent of sequencing technologies has generated a large amount of biological and medical data. These data such as genetic sequencing data and lab experimental evidence data can help understand critical biomedical problems. This dissertation makes contribution in three different but related applications in biomedical research. In Chapter 2, we...
Keyword:: Normalization, Metagenomics, Graph neural network, Clustering, and Differential abundance test
Subject:: Biostatistics, Statistics, and Bioinformatics
Creator:: Ma, Yuanjing
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15057 and etdadmin_upload_736532

Description:: The focus of this thesis is on evaluating, designing, and applying statistical methods that elucidate molecular mechanisms by seeking to understand the pathways that contribute to disease. Chapter 1 introduces the field and motivates the work in this thesis. Chapters 2, 3, and 4 describe original work. Chapter 5 recapitulates...
Keyword:: Gene expression, Algorithms, Pathways, Networks, and Systems biology
Subject:: Statistics and Bioinformatics
Creator:: Shah, Sahil D
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14812 and etdadmin_upload_685626

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