Approximately 1 in 3 deaths in the US is caused by cardiovascular diseases, among them atherosclerosis. Atherosclerosis occurs through excessive cholesterol deposition (hyperlipidemia) along the inner layer of the artery called the intima, resulting in plaque formation that blocks arterial blood flow and could lead to heart attacks and strokes....
Due to their ability to be engineered for specific cellular targeting, nanoparticles (NPs) have emerged as promising drug delivery vessels for immunotherapeutic and vaccination treatments. However, a major unsolved obstacle for cell-specific nanoparticle delivery is non-specific circulatory clearance by the mononuclear-phagocytic system(MPS). Comprised of various phagocytic cells, the MPS removes...
Bacterial microcompartments (BMCs) are proteinaceous organelles contained within prokaryotes used to facilitate reactions with increased efficiency, or to carry out reactions with intermediates that are harmful to the cell if released into the cytoplasm. Oftentimes, compartments are used to metabolize unique carbon sources, such as 1,2-propanediol (1,2-PD), whose metabolic pathway...