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Engineering Protein Scaffolds as Programmable Cancer Therapeutics

Description:

Biological therapeutics have revolutionized the way we treat cancer due to their ability to target tumors discriminately, leaving healthy cells unaffected. However, our inability to tailor the structure of biologics may hamper their optimization for efficacy. This lack of programmability contributes to factors such as immunogenic responses, inability to penetrate...

Keyword:

Nanotechnology, Cancer therapy, Synthetic biology, Synthetic chemistry, Protein engineering, and Protein scaffolds

Subject:

Bioengineering, Chemistry, and Chemical engineering

Creator:

Kimmel, Blaise Russel

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_852716 and http://dissertations.umi.com/northwestern:15804
Microfluidics on Self-Assembled Monolayers for Analyzing Biological and Chemical Reactions

Description:

Recent advances in combinatorial chemistry, synthetic biology, and ‘omics’ research require high-throughput methods for performing and analyzing thousands to millions of reactions in one day. However, it is a challenge to engineer high-throughput systems that can autonomously conduct and analyze such a large number of reactions in a generalizable and...

Keyword:

Self-assembled monolayers, Kinetics, Spatiotemporal, SAMDI Mass Spectrometry, MALDI Imaging Mass Spectrometry, and Microfluidics

Subject:

Bioengineering, Chemistry, and Chemical engineering

Creator:

Grant, Jennifer

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14444 and etdadmin_upload_625853

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Engineering Protein Scaffolds as Programmable Cancer Therapeutics

Microfluidics on Self-Assembled Monolayers for Analyzing Biological and Chemical Reactions

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