Peptides consists of a series of amino acids connected via an amide type of covalent chemical bond. A diverse field of applications such as biosensors,2 catalysis,4 and biomedicine6 include the oligomeric forms of peptides due to their genuine features comparing to other biomacromolecules. Particularly, peptides in the field of biomedical...
Chemical modifications of oligonucleotides (ONs) have advanced these molecules towards clinical approvals. On their own, native ONs have poor pharmacokinetic properties, such as rapid degradation by nucleases and poor cell uptake, which limit their potential therapeutic applications. Chemical modifications of ONs can increase their stability, alter their interactions with cells,...
Despite the increasing interest in biogenic secondary organic aerosols (SOAs), their role in the climate system remains the greatest source of uncertainty in global models. Cloud formation, critical for the net cooling effect provided by cloud cover, is dependent on the abundance of SOA particles and their ability to activate...
The development of new catalytic methodologies for the precision synthesis of carbon-carbon bonds is central to the advancement of synthetic organic chemistry. Significant focuses of these efforts are made on the enantio- and diastereoselective synthesis of carbon frameworks, especially as chemists and biologists become more aware of the impact of...
Synthesis opens the pathway to examine a plethora of complex structures. Whether the target is a naturally occurring compound or a proposed molecule never observed before, synthetic routes can be developed to help understand a variety of properties that the molecule can contain. Synthetic efforts have helped elucidate the absolute...
As the interest in rational synthesis for solid-state materials accelerates, there is an urgent need to understand the design principles concealed within these reactions. In situ material synthesis provides such an avenue to not only uncover these assembling rules, but also for finding new materials even in seemingly familiar phase...
Recent advances in combinatorial chemistry, synthetic biology, and ‘omics’ research require high-throughput methods for performing and analyzing thousands to millions of reactions in one day. However, it is a challenge to engineer high-throughput systems that can autonomously conduct and analyze such a large number of reactions in a generalizable and...
The use of light to understand detailed electronic structure and chemical properties of a molecule through light-matter interaction is fundamentally essential to design and analyze any chemical system. Over the past decades, rapid developments on optics and laser techniques improved the detection efficiency of multiphoton processes with more detailed chemical...
Metalloenzymes catalyze remarkable reactions in Nature using transition metal ions. Common earth-abundant metals like copper, iron, zinc, and magnesium catalyze reactions that are the basis of life. These metal sites lend their chemistries to facilitate these reactions, making studying the structure and properties important in understanding the enzymes' abilities and...
This thesis presents results on photophysics and spin dynamics of photoactive organic molecules that possess one unpaired electron spin in the ground state and two or three unpaired spins upon photoexcitation. The excited state dynamics of the systems were studied using transient optical absorption spectroscopies and non-Boltzmann population on the...