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Loss of Transcriptional Repression by Adipocyte BCL6 Results in Adiposity and Insulin Sensitivity

Description:

The epidemic of obesity and associated metabolic diseases have led to increased scrutiny of adipose tissue and its primary cell type, the adipocyte. However, studies show that regional adipose tissue distribution rather than obesity per se is a major determinant of metabolic disease risk. Despite having an obese body mass...

Keyword:

Lipogenesis, Insulin Sensitivity, Hypertrophy, Obesity, BCL6, and Adipocyte

Subject:

Biology, Endocrinology, and Genetics

Creator:

Senagolage, Madhavi Dushyanthi

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14575 and etdadmin_upload_658480
Investigation of the Genetic Architecture of Polycystic Ovary Syndrome

Description:

Polycystic ovary syndrome (PCOS) is among the most common endocrine disorders of premenopausal women, affecting 5-15% of this population depending on the diagnostic criteria applied. It is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. PCOS is highly heritable, but only a small proportion of this heritability can be...

Keyword:

complex trait genetics, rare variants, DENND1A, PCOS, and sub-phenotyping

Subject:

Bioinformatics, Genetics, and Endocrinology

Creator:

Dapas, Matthew

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14662 and etdadmin_upload_662808

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Loss of Transcriptional Repression by Adipocyte BCL6 Results in Adiposity and Insulin Sensitivity

Investigation of the Genetic Architecture of Polycystic Ovary Syndrome

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