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Development of Delivery Vehicles and 3-Dimensional Cancer Models to Investigate Gli Inhibition in Basal Cell Carcinoma

Description:

The worldwide community of patients affected by Basal Cell Carcinoma of the skin (BCC) is larger than that of any other cancer. While BCC is rarely lethal, currently available treatment strategies often leave patients with disfiguring scars on their faces, heads, and necks. Moreover, the high recurrence rates of BCC...

Keyword:

zinc finger transcription factors, 3D skin cancer model, Basal Cell Carcinoma, Gli transcription factors, cobalt-Schiff base, and graphene oxide

Subject:

Inorganic chemistry, Biology, and Biochemistry

Creator:

Dukes, Meghan Ward

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

09/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_923011 and http://dissertations.umi.com/northwestern:16188
Metal Ion Fluxes and Localization in Amphibian Fertilization

Description:

Meiosis is a highly regulated process necessary for proper chromosome division. Zincfluxes regulate mammalian meiosis; between prophase I and metaphase II, total intracellular zinc increases by 50%, while 20% of zinc is released in “zinc sparks” following fertilization. Although zinc fluxes had been shown to be conserved in mammals, it...

Keyword:

Xenopus, Sample Fixation, Zinc, Manganese, Fertilization, and EMI2

Subject:

Inorganic chemistry, Biology, and Biochemistry

Creator:

Seeler, John Frederick

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/28/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_819316 and http://dissertations.umi.com/northwestern:15573

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Development of Delivery Vehicles and 3-Dimensional Cancer Models to Investigate Gli Inhibition in Basal Cell Carcinoma

Metal Ion Fluxes and Localization in Amphibian Fertilization

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