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  1. Analysis of Latent Membrane Protein (LMP) 2A Signaling Through Src Family Kinases and the Role of LMP2B in Modulating LMP2A Signaling

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    Description: Latent membrane protein 2A (LMP2A) and LMP2B are viral proteins expressed during Epstein-Barr virus (EBV) latency in EBV-infected B cells both in cell culture and in vivo. Although Lyn has been shown to be important in mediating LMP2A signaling, it is still unclear if Lyn is used preferentially or if...
    Keyword: Molecular and Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Mark Rovedo
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/18/2018
    Date Modified: 09/18/2018
    Date Created: 2008-09-03
    Rights: In Copyright
    Resource Type: Dissertation
  2. Mechanism of Nuclear Import of a Smooth Muscle Cell-Specific Plasmid Vector for Gene Therapy

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    Description: Cardiovascular disease is a leading cause of morbidity and mortality worldwide. While many therapies have been used to treat vascular disease symptomatically, gene therapy offers a means of treating the molecular dysfunctions driving disease pathogenesis. Unfortunately, gene therapy has achieved only modest therapeutic success in clinical trials due to a...
    Keyword: nuclear localization signal, plasmid, nuclear import, karyopherins, and gene therapy
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Aaron Michael Miller
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/17/2018
    Date Modified: 09/17/2018
    Date Created: 2008-08-01
    Rights: In Copyright
    Resource Type: Dissertation
  3. Structural and Functional Analyses of Herpes Simplex Virus Type1 Glycoproteins B and L, Two Essential Components of the Viral Fusogenic Complex

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    Description: Herpes simplex virus (HSV) infection of host cells requires virus attachment to the cell surface and subsequent membrane fusion between the virus envelope and host cell membrane to deliver the nucleocapsid containing the viral genome into the host cell. A proposed mechanism for HSV glycoprotein-induced membrane fusion is gD binding...
    Keyword: Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Erick Lin
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/17/2018
    Date Modified: 09/17/2018
    Date Created: 2008-07-17
    Rights: In Copyright
    Resource Type: Dissertation
  4. The Regulation of Infection-Induced Cardiac Autoimmunity and Natural Dissemination of Trypanosoma cruzi in Experimental Chagas Heart Disease

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    Description: Chagas heart disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is still regarded as a major public health problem in Central and South America. The finding of cardiac specific autoimmunity during infection in both humans and experimental animals has provided a basis for investigation of its potential role...
    Keyword: Myosin, Cardiac, Trypanosoma cruzi, Luminescence, Chagas, and Autoimmunity
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Kenneth Vincent Hyland
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-11-10
    Rights: In Copyright
    Resource Type: Dissertation
  5. The modulation of MFG-E8 mediated microglial phagocytosis

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    Description: Phagocytosis is an essential mechanism for clearance of pathogens, dying cells, and other unwanted debris in order to maintain tissue health in the body. Macrophages execute this process in the peripheral immune system, but in the brain microglia act as resident macrophages to accomplish this function. In the peripheral immune...
    Keyword: microglia, phagocytosis, MFG-E8, apoptosis, Gas6, and Alzheimer's disease
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Abby Denise Fuller
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-08-11
    Rights: In Copyright
    Resource Type: Dissertation
  6. Estrogen Neuroendocrine Feedback is Mediated Distinctly via Estrogen Response Element Dependent and Independent Estrogen Receptor Alpha Signaling

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    Description: Gonadotropins LH and FSH are secreted by the pituitary in response to hypothalamic GnRH and act to stimulate ovarian follicle development, steroid production and ovulation. Gonadal steroids, including estrogen, enter the circulation and provide neuroendocrine feedback at the hypothalamus and/or pituitary. Estrogen provides negative feedback to suppress gonadotropin release throughout...
    Keyword: Classical, Neuroendocrinology, Estrogen, Non-classical, Nonclassical, and Reproduction
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Christine Ann Glidewell-Kenney
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-07-15
    Rights: In Copyright
    Resource Type: Dissertation
  7. The Kinesin-1 Motor Domain is Regulated by a Direct Interaction of its Head and Tail

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    Description: Kinesin-1 is a motor protein that transports cargo along microtubules. Inside cells, the majority of kinesin-1 is regulated to conserve ATP and ensure its proper intracellular distribution and coordination with other motors. Regulated kinesin-1 is folded in half, and interactions between coiled-coil regions near the N-terminal enzymatically active heads and...
    Keyword: kinesin and regulation
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Kristen Dietrich
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-11-04
    Rights: In Copyright
    Resource Type: Dissertation
  8. Characterizing Critical Residues for the Interaction of Human Immunodeficiency Virus Type 1 Integrase with DNA Substrates

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    Description: A tetramer model for HIV-1 Integrase (IN) with DNA representing the LTR termini was previously assembled which predicted amino acid residues on the enzyme surface that interact with the LTR termini (Chen et al, 2006). A separate structural alignment of HIV-1, SIV, and ASV INs predicted which of these residues...
    Keyword: Integrase, HIV, DNA, and model structure
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: James Robert Dolan
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/14/2018
    Date Modified: 09/14/2018
    Date Created: 2008-08-27
    Rights: In Copyright
    Resource Type: Dissertation
  9. The Role of Early Growth Response Transcription Factors in Hematopoietic Development

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    Description: The orderly process of hematopoietic differentiation is governed in large part by the coordinated transcription of specific genes. Deregulation of normal differentiation processes can lead to disease states including immunodeficiency, autoimmune disease, and leukemia. This research focuses on the family of transcription factors known as the early growth response (Egr)...
    Keyword: thymocyte, Egr, macrophage, and transcription
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: John Carter
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/12/2018
    Date Modified: 09/12/2018
    Date Created: 2008-05-09
    Rights: In Copyright
    Resource Type: Dissertation
  10. Mechanisms of hyperoxia-induced senescence in primary human lung fibroblasts

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    Description: Senescence, permanent, irreversible replication arrest that occurs in all primary cells studied to date, is considered a cellular model of aging. Recently, senescence has gained attention as a potential tumor-suppressing mechanism. However, despite the obvious importance of senescence, its exact mechanisms remain unclear. One current hypothesis to explain senescence postulates...
    Keyword: hyperoxia, aging, p53, reactive oxygen species, and senescence
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Tatyana A Klimova
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/10/2018
    Date Modified: 09/10/2018
    Date Created: 2008-05-08
    Rights: In Copyright
    Resource Type: Dissertation