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  1. Derivation of Cardiomyocytes from Embryonic Stem cells and Development of Techniques to Study Cardiac Lineage

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    Description: Embryonic stem cells have the potential to differentiate into ectodermal, mesodermal and endodermal derivatives. This property makes them a valuable source of tissue specific progenitor and differentiated cells that can be used for cell replacement therapy. The first goal of this thesis is to test if cardiogenesis from embryonic stem...
    Keyword: Cell Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Achuta K Guddati
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/08/2018
    Date Modified: 10/08/2018
    Date Created: 2008-05-09
    Rights: In Copyright
    Resource Type: Dissertation
  2. Luteinizing Hormone Receptor Signaling Regulates MAP2D Phosphorylation in Preovulatory Granulosa Cells

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    Description: The actions of luteinizing hormone (LH) to induce ovulation and luteinization of preovulatory follicles are mediated principally by activation of cAMP-dependent protein kinase (PKA) in granulosa cells. PKA activity is targeted to specific cellular locations by A-kinase anchoring proteins (AKAPs). I previously showed that follicle-stimulating hormone (FSH) induces expression of...
    Keyword: MAP2, granulosa cell, ovary, luteinizing hormone, cyloskeleton, and vimentin
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Maxfield Patrick Flynn
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/03/2018
    Date Modified: 10/03/2018
    Date Created: 2008-08-11
    Rights: In Copyright
    Resource Type: Dissertation
  3. Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

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    Description: PRC is a PGC-1 coactivator family member responsive to serum growth factors and up regulated in proliferating cells. Unlike PGC-1α and PGC-1β, PRC has not been studied extensively and and its function or regulation remains largely unknown. Both PGC-1α and PGC-1β have been shown to be important regulators of mitochondrial...
    Keyword: Chemical and Biochemistry
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Kristel Vercauteren
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/02/2018
    Date Modified: 10/02/2018
    Date Created: 2008-12-08
    Rights: In Copyright
    Resource Type: Dissertation
  4. Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

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    Description: Early Growth Response genes (Egr1-4) are transcriptional mediators of signals governing growth and differentiation. In sympathetic neuron-derived cell lines, Egr1 is induced by NGF signaling, which is required for sympathetic neuron survival, differentiation and target organ innervation. In the absence of identifiable sympathetic defects in Egr1-deficient mice, we investigated the...
    Keyword: NGF, sympathetic nervous system, and Egr3
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Laurie Christine Eldredge
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/01/2018
    Date Modified: 10/01/2018
    Date Created: 2008-12-08
    Rights: In Copyright
    Resource Type: Dissertation
  5. Structural and Conformational Requirements of Membrane Fusion Mediated by the Parainfluenza Virus 5 Fusion Protein

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    Description: Fusion of biological membranes is dictated by the interaction between specialized membrane proteins and the lipid bilayer. Parainfluenza virus 5 (PIV5) mediates fusion using two surface glycoproteins: the fusion protein (F) and the attachment protein hemagglutinin-neuraminidase (HN). Activation of membrane fusion of PIV5 typically occurs at neutral pH, and involves...
    Keyword: fusion protein, Class I virus fusion, Membrane fusion, and PIV5
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Mei Lin Bissonnette
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/01/2018
    Date Modified: 10/01/2018
    Date Created: 2008-11-06
    Rights: In Copyright
    Resource Type: Dissertation
  6. The Role of TGF-beta Variants in Breast Cancer

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    Description: TGF-β has been named the molecular Jekyll and Hyde of cancer due to its ability to both suppress and promote tumor development. Components of the TGF-β signaling pathway are often mutated in cancer to inhibit the tumor suppressor roles of TGF-β. Our lab studies how a 3-alanine deletion in the...
    Keyword: Genetics and Biology
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Diana Susan Rosman
    Owner: Scholarly Digital Publishing
    Date Uploaded: 10/01/2018
    Date Modified: 10/01/2018
    Date Created: 2008-10-14
    Rights: In Copyright
    Resource Type: Dissertation
  7. Plakophilin 2: Critical Roles in Intercellular Junction Assembly and Maturation via Regulation of Protein Kinase C and Actin

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    Description: Desmosomes are adhesive complexes found at sites of intercellular contact that are essential for mediating cell-cell adhesion. These junctions undergo regulated assembly and reorganization during processes such as embryogenesis and wound healing. Plakophilins (PKPs) are armadillo family members related to the classic cadherin-associated protein p120ctn. PKPs localize to the cytoplasmic...
    Keyword: armadillo, plakophilin, cytoskeleton, cell-cell adhesion, and desmosome
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Amanda Elisabeth Bass-Zubek
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/20/2018
    Date Modified: 09/20/2018
    Date Created: 2008-09-18
    Rights: In Copyright
    Resource Type: Dissertation
  8. Energy Deprivation Elevates BACE1 Protein Levels and Promotes Amyloidogenesis via EIF2alpha Phosphorylation

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    Description: The cause(s) of Aβ overproduction and accumulation in SAD are unknown; however, several lines of evidence indicate that impaired energy metabolism in the brain may be involved. Furthermore, the rate-limiting enzyme in Aβ production, BACE1, is elevated in SAD brains around amyloid plaques, indicating that BACE1 may also play a...
    Keyword: amyloid, energy metabolism, BACE1, Alzheimer's disease, and translation
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Tracy O'Connor
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/20/2018
    Date Modified: 09/20/2018
    Date Created: 2008-12-04
    Rights: In Copyright
    Resource Type: Dissertation
  9. Mechanisms of RNA Mediated Silencing in S. pombe

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    Description: Mechanisms of RNA Mediated Silencing in S. pombe Christina A. Lawrence Heterochromatin of eukaryotic genomes has classically been defined as condensed chromatin that is repressive to transcription and typically resides at highly repetitive regions of the genome. Genetic and molecular analyses have demonstrated that these regions are essential for genome...
    Keyword: Yeast, epigenetics, heterochromatin, and RNAi
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Christina Lawrence
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/20/2018
    Date Modified: 09/20/2018
    Date Created: 2008-12-05
    Rights: In Copyright
    Resource Type: Dissertation
  10. Epstein-Barr Virus Glycoprotein 42: The Dynamic Trigger of B-cell Membrane Fusion

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    Description: Epstein-Barr virus (EBV) is a human herpesvirus that is able to infect both epithelial cells as well as B lymphocytes, where the virus stablishes life-long latency in the host. Five glycoproteins are involved in infection of B cells: gp350/220 for initial tethering of the virus to the cell via CD21,...
    Keyword: gp42, Epstein-Barr virus, herpesviruses, membrane fusion, viral entry, and inhibitory peptide
    Subject: Integrated Graduate Program in the Life Sciences
    Creator: Amanda Renee Kim Eun-Ja Silva Lowrey
    Owner: Scholarly Digital Publishing
    Date Uploaded: 09/20/2018
    Date Modified: 09/20/2018
    Date Created: 2008-12-01
    Rights: In Copyright
    Resource Type: Dissertation