Index Catalog // Arch : Northwestern University Institutional Repository

Regulation of FucT-VII expression in CD4-positive T cells

Description:: CD4-positive T cells express ligands for E- and P-selectins, carbohydrate-binding adhesion molecules that are induced on inflamed endothelium. The interaction between selectins and the selectin ligands facilitates the migration of T cells to sites of inflammation. The fucosyltransferase FucT-VII is essential for selectin ligand formation but the signaling and transcriptional...
Keyword:: Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Dimitrios G. Zisoulis
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/09/2018
Date Modified:: 05/09/2018
Date Created:: 2006-12-11
Resource Type:: Dissertation

DISSECTING THE ROLE OF C53 IN REGULATION OF CELL CYCLE AND CELL DEATH

Description:: Regulation of cell cycle and cell death are critical for normal cellular proliferation, tissue homeostasis, animal development, and the pathogenesis of human diseases such as cancer. Irregularities in cell cycle and cell death may result in tumorigenesis. In this dissertation, I describe my studies of a novel gene C53, which...
Keyword:: Mitosis, Cell Cycle, G2/M checkpoint, Cell Death, and C53
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Hai Jiang
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/09/2018
Date Modified:: 05/09/2018
Date Created:: 2006-12-12
Resource Type:: Dissertation

Modeling Cell Protrusion by a Population of Actin Filaments

Description:: Actin polymerization is responsible for the protrusion of filopodia and lamellipodia in immune, cancer, and other motile cells, as well as for propulsion of some intra cellular pathogens. Protrusion of a lamellipodium by the very filaments supporting the membrane load operates by the Brownian ratchet mechanism, with overall organization governed...
Keyword:: simulation, energetics, protrusion, actin, lamellipodium, and stochastic
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Thomas Schaus
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/30/2018
Date Modified:: 08/30/2018
Date Created:: 2007-12-10
Resource Type:: Dissertation

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Description:: PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
Keyword:: Microbiology and Biology
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Maria Soderberg
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/06/2018
Date Modified:: 09/06/2018
Date Created:: 2008-03-25
Resource Type:: Dissertation

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Description:: PRC is a PGC-1 coactivator family member responsive to serum growth factors and up regulated in proliferating cells. Unlike PGC-1α and PGC-1β, PRC has not been studied extensively and and its function or regulation remains largely unknown. Both PGC-1α and PGC-1β have been shown to be important regulators of mitochondrial...
Keyword:: Biochemistry and Chemical
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Kristel Vercauteren
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/02/2018
Date Modified:: 10/02/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Description:: Early Growth Response genes (Egr1-4) are transcriptional mediators of signals governing growth and differentiation. In sympathetic neuron-derived cell lines, Egr1 is induced by NGF signaling, which is required for sympathetic neuron survival, differentiation and target organ innervation. In the absence of identifiable sympathetic defects in Egr1-deficient mice, we investigated the...
Keyword:: NGF, sympathetic nervous system, and Egr3
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Laurie Christine Eldredge
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/01/2018
Date Modified:: 10/01/2018
Date Created:: 2008-12-08
Resource Type:: Dissertation

Energy Deprivation Elevates BACE1 Protein Levels and Promotes Amyloidogenesis via EIF2alpha Phosphorylation

Description:: The cause(s) of Aβ overproduction and accumulation in SAD are unknown; however, several lines of evidence indicate that impaired energy metabolism in the brain may be involved. Furthermore, the rate-limiting enzyme in Aβ production, BACE1, is elevated in SAD brains around amyloid plaques, indicating that BACE1 may also play a...
Keyword:: translation, energy metabolism, BACE1, amyloid, and Alzheimer's disease
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Tracy O'Connor
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-04
Resource Type:: Dissertation

Mechanisms of RNA Mediated Silencing in S. pombe

Description:: Mechanisms of RNA Mediated Silencing in S. pombe Christina A. Lawrence Heterochromatin of eukaryotic genomes has classically been defined as condensed chromatin that is repressive to transcription and typically resides at highly repetitive regions of the genome. Genetic and molecular analyses have demonstrated that these regions are essential for genome...
Keyword:: heterochromatin, Yeast, epigenetics, and RNAi
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Christina Lawrence
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-05
Resource Type:: Dissertation

Epstein-Barr Virus Glycoprotein 42: The Dynamic Trigger of B-cell Membrane Fusion

Description:: Epstein-Barr virus (EBV) is a human herpesvirus that is able to infect both epithelial cells as well as B lymphocytes, where the virus stablishes life-long latency in the host. Five glycoproteins are involved in infection of B cells: gp350/220 for initial tethering of the virus to the cell via CD21,...
Keyword:: membrane fusion, inhibitory peptide, viral entry, Epstein-Barr virus, gp42, and herpesviruses
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Amanda Renee Kim Eun-Ja Silva Lowrey
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/20/2018
Date Modified:: 09/20/2018
Date Created:: 2008-12-01
Resource Type:: Dissertation

Stat3-Dependent Survival and Stat3-Independent Terminal Differentiation in the B Cell Compartment in IL-6 Transgenic Mice

Description:: IL-6 is a pleiotropic cytokine involved in both immune and non-immune functions. In the immune system, IL-6 induces terminal differentiation of B cells into plasma cells, thereby promoting antibody production. IL-6 stimulates growth of T cells by enhancing the expression of the IL-2 receptor, and IL-6 also causes differentiation of...
Keyword:: Health Sciences
Subject:: Integrated Graduate Program in the Life Sciences
Creator:: Sarah E Staggs
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/30/2018
Date Modified:: 08/30/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

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Regulation of FucT-VII expression in CD4-positive T cells

DISSECTING THE ROLE OF C53 IN REGULATION OF CELL CYCLE AND CELL DEATH

Modeling Cell Protrusion by a Population of Actin Filaments

Type II Secretion and Secreted Ppiases Promote Low Temperature Growth and Survival in Legionella pneumophila

Control of Mitochondrial Function and Cell Cycle Progression by PGC-1-Related Coactivator (PRC)

Egr3 is a Novel Transcriptional Regulator of Sympathetic Nervous System Development and Function

Energy Deprivation Elevates BACE1 Protein Levels and Promotes Amyloidogenesis via EIF2alpha Phosphorylation

Mechanisms of RNA Mediated Silencing in S. pombe

Epstein-Barr Virus Glycoprotein 42: The Dynamic Trigger of B-cell Membrane Fusion

Stat3-Dependent Survival and Stat3-Independent Terminal Differentiation in the B Cell Compartment in IL-6 Transgenic Mice

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