Index Catalog // Arch : Northwestern University Institutional Repository

Organoids model distinct vitamin E effects at different stages of prostate cancer evolution

Description:: Prostate cancer (PCa) is the most common non-cutaneous cancer among U.S. men. Lack of effective treatments for advanced disease make it a significant public health concern. However, PCa’s long natural history makes it an excellent target for prevention approaches that reduce overtreatment of indolent disease, treatment related morbidity, and mortality....
Keyword:: SELECT, Extracellular matrix, Prostate cancer, Reactive Oxygen Species, Organoids, and Fatty Acid Oxidation
Subject:: Molecular biology, Biology, and Cellular biology
Creator:: Njoroge, Rose Nyawira
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14428 and etdadmin_upload_623433

Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6

Description:: Transcription is tightly regulated to ensure genes are appropriately expressed both temporally and spatially. This tight regulation governs various processes within the cell, such as differentiation and cell identity, cellular maintenance, and dynamic responses to external signals. Transcription factors (TFs) coordinate these various gene programs and in particular, are key...
Keyword:: Repressor, NAFLD, PPAR alpha, BCL6, Transcription, and Metabolism
Subject:: Molecular biology and Biology
Creator:: Sommars, Meredith Anne
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_663025 and http://dissertations.umi.com/northwestern:14672

Requirement of the Caspase-3 Homologue DrICE in Drosophila Tracheal Size Control

Description:: Proper size control of organs and tissues is critical to their function, and it is necessary for the millions of precisely sized tubes that make up those organs— for example, excessive cell growth can lead to devastating diseases such as Polycystic Kidney Disease. The regulation of tube growth is therefore...
Keyword:: Trafficking, Non-apoptotic, Trachea, Caspase, and Apoptosis
Subject:: Molecular biology, Biology, and Cellular biology
Creator:: McSharry, Saoirse Susan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_661142 and http://dissertations.umi.com/northwestern:14599

Characterization of HKDC1 and Involvement in NAFLD Development

Description:: The literature has established glucokinase (GCK) to be the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. We have recently proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1...
Keyword:: Hexokinase, NAFLD, Liver Metabolism, and HKDC1
Subject:: Molecular biology, Biology, and Biochemistry
Creator:: Pusec, Carolina
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14450 and etdadmin_upload_626205

Tissue Assembly and Pattern Control in Planarian Brain Regeneration

Description:: Many human diseases are chronic and ultimately fatal because they damage organs and tissues beyond the body’s normal repair mechanisms. Therefore, there is significant medical interest in developing pharmaceuticals that enhance the body’s natural injury repair mechanisms and engineering organs in the lab for transplantation. However, comparatively little is known...
Subject:: Molecular biology and Biology
Creator:: Bonar, Nicolle
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14713 and etdadmin_upload_668640

Enhancer Malfunction Underlies Transcriptional Dysregulation in Uterine Leiomyoma

Description:: Uterine leiomyomas (fibroids) are a major source of gynaecologic morbidity in reproductive age women and are characterised by the excessive deposition of a disorganised extracellular matrix, resulting in rigid benign tumours. Clinically, leiomyoma patients usually present with pelvic pain, urinary incontinence, as well as heavy cyclic and non-cyclic bleeding. Curative...
Subject:: Molecular biology, Bioinformatics, and Biology
Creator:: Moyo, Mthabisi Bongani
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 01/21/2021
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_723828 and http://dissertations.umi.com/northwestern:15028

Enhancer Malfunction Underlies Transcriptional Dysregulation in Uterine Leiomyoma

Description:: Uterine leiomyomas (fibroids) are a major source of gynaecologic morbidity in reproductive age women and are characterised by the excessive deposition of a disorganised extracellular matrix, resulting in rigid benign tumours. Clinically, leiomyoma patients usually present with pelvic pain, urinary incontinence, as well as heavy cyclic and non-cyclic bleeding. Curative...
Subject:: Molecular biology, Bioinformatics, and Biology
Creator:: Moyo, Mthabisi Bongani
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_723828 and http://dissertations.umi.com/northwestern:15028

Inhibitory Effects of the MNK1/2 Inhibitor Tomivosertib in Acute Myeloid Leukemia

Description:: The treatment of AML remains to be a challenge due to the high rates of resistance and relapse experienced by patients after initial therapy. The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for AML due to their critical role in malignant hematopoietic transformation via...
Subject:: Molecular biology, Biology, and Biochemistry
Creator:: Suarez Palacios, Milagros Melanie
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_845430 and http://dissertations.umi.com/northwestern:15772

CD81 Partners with CD44 in Promoting Exosome Integrity, Tumor Cell Cluster Formation, and Lung Metastasis in Triple Negative Breast Cancer

Description:: Tumor-initiating cells with reprogramming plasticity are thought to be essential for cancer development and metastatic regeneration in many cancers; however, the molecular mechanisms are not fully understood. We have previously identified that CD44, a breast tumor-initiating cell marker, drives mammosphere self-renewal and multicellular aggregation of circulating tumor cell (CTC) clusters,...
Keyword:: exosomes, CD44, cancer stem cells, extracellular vesicles, CD81, and breast cancer
Subject:: Molecular biology, Biology, and Cellular biology
Creator:: Ramos, Erika Kathryn
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16152 and etdadmin_upload_916551

Investigation of the Initiation, Progression and Treatment of Pediatric Gliomas

Description:: Pediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in H3F3A, the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine at position 34 of H3.3 with either Arginine or Valine (H3.3G34R/V), was recently described and characterized in a large cohort...
Keyword:: genetics, G34R, cancer, ATRX, glioma, and AVB500
Subject:: Molecular biology, Biology, and Biochemistry
Creator:: Abdallah, Aalaa Sanad
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16475 and etdadmin_upload_978815

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Organoids model distinct vitamin E effects at different stages of prostate cancer evolution

Genomic Coordination of Hepatic Lipid Metabolism and Fasting by BCL6

Requirement of the Caspase-3 Homologue DrICE in Drosophila Tracheal Size Control

Characterization of HKDC1 and Involvement in NAFLD Development

Tissue Assembly and Pattern Control in Planarian Brain Regeneration

Enhancer Malfunction Underlies Transcriptional Dysregulation in Uterine Leiomyoma

Enhancer Malfunction Underlies Transcriptional Dysregulation in Uterine Leiomyoma

Inhibitory Effects of the MNK1/2 Inhibitor Tomivosertib in Acute Myeloid Leukemia

CD81 Partners with CD44 in Promoting Exosome Integrity, Tumor Cell Cluster Formation, and Lung Metastasis in Triple Negative Breast Cancer

Investigation of the Initiation, Progression and Treatment of Pediatric Gliomas

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