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Description:: Bacteria often coordinate virulence factors to fine-tune the host response during infection. These coordinated events can include toxins counteracting or amplifying effects of another toxin or though regulating the stability of virulence factors to remove their function once it is no longer needed. Multifunctional autoprocessing repeats-in toxin (MARTX) toxins are...
Keyword:: Toxin, MAPK, IL-8, Vibrio vulnificus, MARTX, and Vibrio cholera
Subject:: Microbiology, Molecular biology, and Immunology
Creator:: Woida, Patrick James
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15369 and etdadmin_upload_778406

Description:: Symbiotic relationships involve a life-long interaction between host and bacteria, and there is much we do not understand about how these interactions are developed and maintained. During the horizontal recruitment of beneficial bacteria by hosts, a complex set of molecular signals and communication ensures specificity. On the bacterial side, these...
Keyword:: Vibrio fischeri, symbiosis, biofilm, and two-component signaling systems
Subject:: Microbiology and Molecular biology
Creator:: Ludvik, Denise Alberta
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15608 and etdadmin_upload_825957

Description:: Cytokines made by macrophages play a critical role in determining the course of Legionella pneumophila infection. Prior, murine-based modeling indicated that the cytokine response initiated upon recognition of L. pneumophila involves a subset of Toll-like receptors, namely TLR2, TLR5, and TLR9. Using shRNA/siRNA knockdowns and subsequently CRISPR/Cas9 knockouts (KO), I...
Keyword:: TLR4, Legionella pneumophila, Macrophage , Toll-like Receptors, and TLR3
Subject:: Microbiology, Molecular biology, and Immunology
Creator:: Grigoryeva, Lubov Sergeevna
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_839521 and http://dissertations.umi.com/northwestern:15684

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