Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Nucleic acid therapeutics can be drug molecules with high programmability, minimal off-target effects, and the capability to address “undruggable” targets for diseases. In addition, each time a new drug is needed, one needs to only change the sequence as opposed to finding an entirely new structure. One nucleic acid type...
Keyword:: RNAi, siRNA, gene therapy, structure-function, spherical nucleic acid, and nanoparticle
Subject:: Nanotechnology, Pharmaceutical sciences, and Biomedical engineering
Creator:: Vasher, Matthew Kuo
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_938909 and http://dissertations.umi.com/northwestern:16319

Description:: Nanocarriers, structures with at least one dimension on the nanoscale (1-1000 nm), have been engineered for delivery of various cargoes. The shape and flexibility of nanocarriers are important parameters that influence their biological performance. Self-assembling polymeric filamentous nanocarriers, known as filomicelles (FM), are of great interest to nanomedicine due to...
Keyword:: flexibility, circulation time, flash nanoprecipitation, pi-stacking, nanoparticles, and filaments
Subject:: Nanotechnology, Nanoscience, and Biomedical engineering
Creator:: Li, Sophia
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_856044 and http://dissertations.umi.com/northwestern:15821

Description:: Like many diseases, atherosclerotic cardiovascular disease is driven by the activity of inflammatory cells. Using molecular imaging to target and analyze populations of inflammatory cells is one promising strategy to non-invasively assess atherosclerosis progression. However, current molecular imaging contrast agents are not suited for such targeted imaging applications. Nanomaterial-based strategies...
Keyword:: Nanomaterials, Targeted delivery, Nanoparticles, Magnetic resonance imaging, and Drug delivery
Subject:: Nanotechnology, Nanoscience, and Biomedical engineering
Creator:: Modak, Mallika
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_836754 and http://dissertations.umi.com/northwestern:15664

Description:: Nanoparticles are nanometer scale (1-1000 nm) structures capable of encapsulating a diverse range of cargoes. Encapsulation of a cargo can drastically alter its pharmacokinetics, cytotoxicity, and biodistribution while allowing for informed and rational design of the nanoparticle itself. Poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-b-PPS) is an amphiphilic diblock co-polymer able to self-assemble...
Keyword:: Glaucoma, Latrunculin A, Nanoparticles, and Targeted Delivery
Subject:: Nanotechnology and Biomedical engineering
Creator:: Stack, Trevor
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_815566 and http://dissertations.umi.com/northwestern:15530

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