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-
- Description:
- Nearly all animals exhibit behaviors that can be classified as sleep. The distinctly disadvantageous nature of the asleep state, evolutionarily speaking, accentuates its role as a critical physiological process, yet chronic inadequate sleep is prevalent in today’s society. Among the multitude of health problems that have been linked to chronic...
- Keyword:
- Metabolome, Stress, Sleep, Sleep Deprivation, Microbiome, and PTSD
- Subject:
- Biology and Neurosciences
- Creator:
- Bowers, Samuel James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15162 and etdadmin_upload_749831
-
- Description:
- Basal ganglia are a highly interconnected group of nuclei involved in motor control. The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. While the prevailing basal ganglia circuit model assumes the GPe as merely a relay, phasic changes in the activity of GPe neurons during...
- Subject:
- Neurosciences
- Creator:
- Pamukcu, Arin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_770344 and http://dissertations.umi.com/northwestern:15325
-
- Description:
- Approximately 80-90% of individuals with Parkinson’s disease (PD) develop motor speech impairments, predominantly in the form of voice dysfunction. It is known that the motor symptoms of PD arise from degeneration of the dopamine producing neurons in the substantia nigra and dysregulation of basal ganglia motor pathways. It is also...
- Keyword:
- neuroimaging, dysarthria, fMRI, basal ganglia, hypophonia, and Parkinson's disease
- Subject:
- Neurosciences and Communication
- Creator:
- Manes, Jordan Leigh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_759611 and http://dissertations.umi.com/northwestern:15211
-
- Description:
- Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we used dynamic metabolic labeling with stable isotopes followed by proteomic...
- Keyword:
- Synaptic Vesicles, Alzheimer's Disease, Presynapse, Proteomics, and Protein Degradation
- Subject:
- Neurosciences
- Creator:
- Hark, Timothy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15385 and etdadmin_upload_780177
-
- Description:
- The hippocampus has a well-established role in episodic memory and serves as a hub in a network of distributed brain regions (i.e., hippocampal-cortical network; HCN). Theta-band (4-8 Hz) neural activity recorded in the hippocampus have been associated with memory processing, and synchronized theta oscillations among the hippocampus and HCN regions...
- Subject:
- Neurosciences
- Creator:
- Hermiller, Molly Suzanne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15271 and etdadmin_upload_764537
-
- Description:
- Neural stem and progenitor cell (NPC) fate specification is a crucial component of central nervous system development, and the myriad signaling pathways that guide it are poorly understood. In my thesis work, I aimed to elucidate signaling mechanisms of the bone morphogenetic protein family (BMP) and some of its targets...
- Keyword:
- YAP, Integrin, neural stem cell, TAZ, BMP, and HtrA1
- Subject:
- Neurosciences
- Creator:
- Chen, Jessie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15191 and etdadmin_upload_755327
-
- Description:
- Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) represent a class of non-canonical, ganglion cell photoreceptors. These cells influence a variety of visual behaviors including contrast sensitivity, circadian photoentrainment, sleep, and even mood. These wide-ranging behavioral influences are attributed to the multiple subtypes (M1-6) that comprise the ipRGC population, with different...
- Keyword:
- Development, ipRGCs, Melanopsin, and Retina
- Subject:
- Neurosciences and Developmental biology
- Creator:
- Lucas, Jasmine Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_744013 and http://dissertations.umi.com/northwestern:15132
-
- Description:
- We present two ways in which measures of information can be used for the design and analysis of neural networks in both the brain and the computer. In the brain, stimulus is often represented as a distributed pattern of activity in a network of neurons. The quality of such population...
- Keyword:
- Neural Coding, Fisher Information, Memory, Neural Networks, Population Coding, and Information Theory
- Subject:
- Artificial intelligence, Neurosciences, and Biophysics
- Creator:
- Kim, Hyun Jin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_764291 and http://dissertations.umi.com/northwestern:15264
-
- Description:
- Decisions in naturalistic environments usually feature delayed and uncertain outcomes that can only be reached after a sequence of actions are performed. For example, canonical stalking and pursuit strategies used by terrestrial predators often involve stages of concealment, pauses where the predator remains motionless, and high speed chase sequences. The...
- Keyword:
- Ecology, Evolution, Decision Making, and Computational Neuroscience
- Subject:
- Ecology, Biomedical engineering, and Neurosciences
- Creator:
- Mugan, Ugurcan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_769384 and http://dissertations.umi.com/northwestern:15318
-
- Description:
- Classical conditioning is a form of associative learning and can be used as a behavioral paradigm to model and investigate the neural mechanisms underlying associative learning. In this work, classical conditioning paradigms are used to test the effectiveness of a disease model on the impact of learning and emotional regulation...
- Keyword:
- Memory, Persistent Firing, Entorhinal Cortex, Aging, Learning, and Postburst Afterhyperpolarization
- Subject:
- Neurosciences
- Creator:
- Lin, Carmen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15321 and etdadmin_upload_770003
-
- Description:
- Navigating through the world is typically a multisensory experience. Mammals are believed to navigate using a cognitive map of space stored in the hippocampus. Yet, it is unclear how and whether spatial information of different sensory modalities can contribute to this map. A major barrier to addressing this question has...
- Keyword:
- Vision, 2-photon calcium imaging, Spatial perception, Olfaction, Smellevision, and Spatial cognition
- Subject:
- Cognitive psychology, Behavioral sciences, and Neurosciences
- Creator:
- Radvansky, Brad Allen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15322 and etdadmin_upload_770028
-
- Description:
- Movement and sensing fundamentally works in a synergistic manner. Animal's sensory organs --- be they independently movable like eyes or requiring whole body movement as in the case of electroreceptors --- are actively manipulated throughout stimulus-driven active sensing behaviors. Though these sensing-related motions have been individually reported and analyzed across...
- Keyword:
- behavior, uncertainty, Shannon-Weaver entropy, exploration-exploitation tradeoff, active sensing, and information theory
- Subject:
- Artificial intelligence, Neurosciences, and Engineering
- Creator:
- Chen, Chen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_675222 and http://dissertations.umi.com/northwestern:14742
-
- Description:
- A one-time, unilateral injury to the developing brain can interrupt the typical process of development and result in motor impairments that evolve over the course of the whole life-span. The timing of injury relative to neural development has implications for the continued refinement of the nervous system and the descending...
- Keyword:
- mirror movement, cerebral palsy, corticospinal tract, reaching, pediatric hemiplegia, and flexion synergy
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Hill, Nayo Marel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_792769 and http://dissertations.umi.com/northwestern:15452
-
- Description:
- Research on how sleep contributes to memory has blossomed in recent years. These studies have generally focused on whether or not sleep impacts various types of memory independently. An open question is whether sleep interactively influences different memory types. My research focuses on two types of memory—specificity and generalization. Whereas...
- Keyword:
- memory, sleep, generalization, memory consolidation, and targeted memory reactivation
- Subject:
- Cognitive psychology, Psychobiology, and Neurosciences
- Creator:
- Witkowski, Sarah (Sadie)
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15250 and etdadmin_upload_763727
-
- Description:
- The exchange of information in the brain is accomplished through sequences of action potentials that result from the integration of local microcircuits. Unraveling the connectivity of the neurons that constitute these microcircuits and how they contribute to network activity is vital for understanding how information is relayed through the brain...
- Subject:
- Neurosciences
- Creator:
- Fiske, Michael Patrick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15476 and etdadmin_upload_797275
-
- Description:
- In the vertebrate retina, neurons process visual signals, generating feature selectivity in their activity levels. We use computational models to understand these behaviors by interpreting them mathematically. One component of this analysis is the spatial selectivity or receptive field, a property found in all visual sensory neurons. The neurons found...
- Keyword:
- Vision, Neuron, and Retina
- Subject:
- Neurosciences
- Creator:
- Cooler, Sam
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15450 and etdadmin_upload_792568
-
- Description:
- We present a biophysical model of GCaMP6f calcium fluorescence in CA1 pyramidal neuron dendrites based upon results from imaging and electrophysiology experiments. This work was completed using experimental results from the laboratory of Professor Daniel Dombeck, Department of Neurobiology. Constraining the model to reproduce different objectives --- from in-vitro and...
- Keyword:
- Calcium Model, Dendritic Spines, Computational Neuroscience, Calcium Imaging, and Synaptic Integration
- Subject:
- Applied mathematics and Neurosciences
- Creator:
- Young, Brita Schneiders
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_819855 and http://dissertations.umi.com/northwestern:15589
-
- Description:
- Understanding associative memory is fundamental for a variety of neurological and neurodegenerative diseases, however, a large proportion of this research has excluded female subjects due to unsubstantiated bias. By including intact females, ovariectomized females and males in the study of associative memory, clear sex differences in acquisition emerged. Female mice...
- Subject:
- Neurosciences
- Creator:
- Rapp, Amy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_802347 and http://dissertations.umi.com/northwestern:15501
-
- Description:
- Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...
- Keyword:
- [SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1
- Subject:
- Molecular biology, Bioinformatics, and Neurosciences
- Creator:
- Goncharoff, Dustin Kenneth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538
-
- Description:
- Astrocytes are the most abundant cell type in the brain, yet the mechanisms involved in astrocyte differentiation and the level of astrocyte heterogeneity in the CNS, particularly in the human cortex, is largely unknown due to the lack of subtype-specific astrocyte markers and inaccessibility of human brain tissue. Here we...
- Keyword:
- Glioblastoma, Stem cells, and Astrocyte
- Subject:
- Neurosciences
- Creator:
- Van Gulden, Stephanie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15549 and etdadmin_upload_817717
-
- Description:
- Coiled-coil helix coiled-coil helix domain containing 10 (CHCHD10) is a nuclear gene that encodes for a mitochondria-enriched protein of unknown function. This type of protein is typically imported into mitochondria via the disulfide relay system which facilitates the formation of disulfide bridges between each coiled-coil helix, resulting in maintenance of...
- Subject:
- Neurosciences
- Creator:
- Ryan, Éanna B.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_799720 and http://dissertations.umi.com/northwestern:15495
-
- Description:
- Understanding associative memory is fundamental for a variety of neurological and neurodegenerative diseases, however, a large proportion of this research has excluded female subjects due to unsubstantiated bias. By including intact females, ovariectomized females and males in the study of associative memory, clear sex differences in acquisition emerged. Female mice...
- Subject:
- Neurosciences
- Creator:
- Rapp, Amy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_802347 and http://dissertations.umi.com/northwestern:15501
-
- Description:
- Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by motor neuron (MN) degeneration and resulting in progressive paralysis and death. ALS is genetically heterogeneous, disease pathophysiology is not completely understood, and there are no effective drug therapies. To develop broadly applicable therapeutics, we examine disease mechanisms in the...
- Keyword:
- ALS, C9orf72, iPSCs, nucleocytoplasmic transport, NEK1, and microtubules
- Subject:
- Molecular biology, Cellular biology, and Neurosciences
- Creator:
- Daley, Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15607 and etdadmin_upload_825395
-
- Description:
- Movement is achieved by combining synaptic inputs from various sources and activating motor unit populations. Motor units are the quantal elements of motor control which act as a neuromechanical transducer that converts sensory inputs into motor output. Because of the tight neuromuscular junctions between motoneuron axon terminals and a large...
- Keyword:
- Human Motor Control, EMG, Delta-F, Motor Units, and PICs
- Subject:
- Neurosciences
- Creator:
- Kim, Edward
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_824453 and http://dissertations.umi.com/northwestern:15604
-
- Description:
- Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
- Keyword:
- iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease
- Subject:
- Molecular biology, Cellular biology, and Neurosciences
- Creator:
- Kim, Soojin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606
-
- Description:
- Chemokines, such as Stromal Derived Factor 1 (SDF-1 or CXCL12) and their G protein coupled receptors (GPCRs) are well known regulators of the development and functions of numerous tissues. CXCL12 has two receptors: CXCR4 and CXCR7 or atypical chemokine receptor 3 (ACKR3). CXCR7 has been described as an atypical “biased”...
- Keyword:
- CXCR4 and CXCR7
- Subject:
- Pharmacology and Neurosciences
- Creator:
- Hopkins, Brittany E
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15737 and etdadmin_upload_844430
-
- Description:
- Coordinated movement relies on the precise and controlled activation of populations of motor units, which convert the commands of the nervous system into muscle forces. Motor unit firing patterns are often nonlinear and generated through the response to a combination of ionotropic excitatory and inhibitory commands, as well as metabotropic...
- Keyword:
- Motor Unit, Stroke, Persistent Inward Currents, Delta-F, Motoneuron, and Aging
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Hassan, Altamash Shamsul
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15718 and etdadmin_upload_843639
-
- Description:
- Processing of sensory information in the brain is a pervasive and fundamental phenomenon across animal species and is involved in both "hard-wired" innate responses as well as learned and adaptive behaviors. Here, I show that the avoidance of hot temperature, a simple innate behavior, contains unexpected plasticity and complex processing...
- Keyword:
- systems neuroscience, sensory navigation, modeling, drosophila, thermosensation, and neural circuits
- Subject:
- Applied mathematics, Biology, and Neurosciences
- Creator:
- Levy, Joshua
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_836701 and http://dissertations.umi.com/northwestern:15663
-
- Description:
- Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
- Keyword:
- Imaging, Contact Sites, Lysosome, Mitochondria, Neurological Disease, and Calcium
- Subject:
- Biology, Medicine, and Neurosciences
- Creator:
- Peng, Wesley J
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15610 and etdadmin_upload_827420
-
- Description:
- Social engagement, or shared attention between a child and caregiver, is a critical process for language and social development. Although previous EEG studies have investigated child social processing in closely controlled, experimental studies, no study has examined the interactive, reciprocal process of naturalistic social engagement. In my first paper, we...
- Subject:
- Developmental psychology and Neurosciences
- Creator:
- Manning, Brittany L
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15820 and etdadmin_upload_855920
-
- Description:
- In memory overgeneralization, details from negatively-valenced episodic memories become excessively generalized to unrelated neutral situations. This is a key cognitive distortion associated with major depressive disorder (MDD), generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD). Stress promotes memory generalization, and this process likely relies on stress-induced changes in dorsal...
- Subject:
- Neurosciences
- Creator:
- Ren, Lynn Yi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_851720 and http://dissertations.umi.com/northwestern:15800
-
- Description:
- Stimulus generalization is a critical mechanism for facilitating behavioral flexibility. Generalization allows the brain to reduce computational demands that would otherwise be necessary to create unique representations for each and every encounter while allowing the ability to deal with the complexity of real-world situations. Stimulus generalization is a fundamental cognitive...
- Keyword:
- discrimination learning, olfactory generalization, peak shift, fMRI, and aversive outcomes
- Subject:
- Neurosciences
- Creator:
- Porter, Daria Boratyn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_777969 and http://dissertations.umi.com/northwestern:15368
-
- Description:
- The dentate gyrus is the first region for information processing within the classic hippocampal trisynaptic circuit, and this position makes it an important structure for the formation of associative memories. The dentate gyrus contains two major types of excitatory neurons: granule cells and mossy cells. While previous work has shown...
- Subject:
- Neurosciences
- Creator:
- Miller, Lisa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_861456 and http://dissertations.umi.com/northwestern:15850
-
- Description:
- Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...
- Keyword:
- induced pluripotent stem cell models, ER stress, protein aggregation, protein folding, and lysosomal dysfunction
- Subject:
- Molecular biology and Neurosciences
- Creator:
- Stojkovska, Iva
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_850723 and http://dissertations.umi.com/northwestern:15793
-
- Description:
- In the adult hippocampus of many mammalian species, populations of newborn dentate granule cells (DGCs) are continuously generated and undergo subsequent activity-dependent neuronal maturation and incorporation into the preexisting hippocampal circuitry. Increasing evidence has demonstrated that these young adult-born DGCs (abDGCs) participate in numerous cognitive and affective processes such as...
- Keyword:
- Neurogenesis, GABA, Adult-born granule cell, Kainate receptor, and GluK2
- Subject:
- Neurosciences
- Creator:
- Zhu, Yiwen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15903 and etdadmin_upload_874789
-
- Description:
- My research at northwestern with Dr. Christina Zelano focused on the human amygdala subnucleithat receive monosynaptic input from the olfactory bulb. Surprisingly little is known about these brain regions, including their potential roles in olfactory and nonolfactory processing. During my PhD, I completed three projects aimed at furthering our understanding...
- Keyword:
- Breathing, Olfaction, Respiration, Amygdala, and Human
- Subject:
- Neurosciences
- Creator:
- Noto, Torben
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16080 and etdadmin_upload_902927
-
- Description:
- Anxiety and depression are highly prevalent, recurrent, and major public health problems. Decades of research has uncovered associations between symptom dimensions of anxiety and depression and abnormal neural activation across executive control-, threat-, and reward-related networks. Recent studies have developed a hierarchical symptom structure of anxiety and depression termed the...
- Keyword:
- Executive Control, Reward, EEG, Threat, Anxiety, and Depression
- Subject:
- Physiology, Psychology, and Neurosciences
- Creator:
- Glazer, James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903824 and http://dissertations.umi.com/northwestern:16106
-
- Description:
- Background: The way in which one perceives their visual world (i.e., bottom-up visual perception) and what one pays attention to in their surroundings (i.e., top-down attention), are critical to uncovering underlying thoughts and cognitions, and impact how one operates in the social world. Individuals with autism spectrum disorder (ASD), a...
- Keyword:
- Eye tracking, Broad Autism Phenotype, Autism, Endophenotype, Local Global Processing, and EEG/ERP
- Subject:
- Cognitive psychology, Psychobiology, and Neurosciences
- Creator:
- Nayar, Kritika
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_898041 and http://dissertations.umi.com/northwestern:16008
-
- Description:
- Herpes simplex virus (HSV) encephalitis (HSE) is the most common cause of sporadic fatal encephalitis, and despite targeted antiviral therapy, outcomes remain poor. While rare in adults, neonates are significantly more susceptible to severe HSV disease. Understanding both the host and viral factors that contribute to pathogenesis is critical to...
- Keyword:
- Inflammasome, Neonate, Encephalitis, and Herpes
- Subject:
- Virology, Immunology, and Neurosciences
- Creator:
- Hayes, Cooper Kincaid
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903123 and http://dissertations.umi.com/northwestern:16088
-
- Description:
- The retina does not act as a simple camera, rather visual information goes through multiple layers of processing before it reaches the brain. Retinal ganglion cells (RGCs) are the output neurons of the retina and process visual information in the retina and then project into the brain. There are over...
- Keyword:
- Vision, Retinal ganglion cells, Neuroscience, and Retina
- Subject:
- Neurosciences
- Creator:
- Wienbar, Sophia Rose
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16017 and etdadmin_upload_898849
-
- Description:
- All animals purposefully navigate feature-rich environments: while exploring, in search of vital resources of food and water, finding mates, and patrolling and marking habitats. During these complex behaviors, continuous analogue input information from peripheral sensory organs guides discrete and digital sequential motor output; accordingly, each action is informed, modulated, or...
- Keyword:
- Rodent, Behavior, Trigeminal, Prrxl1, Somatotopy, and Ingestive
- Subject:
- Neurosciences
- Creator:
- Resulaj, Admir
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_879817 and http://dissertations.umi.com/northwestern:15946
-
- Description:
- The cerebellar cortical system is an extensively studied circuit which is critical for motor learning. While multiple monoamines, such as norepinephrine and serotonin, modulate cerebellar cortical output, the mechanistic details of dopaminergic signaling in the cerebellum remain poorly understood. Additionally, neuronal cell types residing within the cerebellum remain relatively under-characterized....
- Keyword:
- Cerebellum, Dopamine, Unipolar brush cells, and Light sheet microscope
- Subject:
- Neurosciences
- Creator:
- Canton-Josh, Jose Ernesto
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15996 and etdadmin_upload_896041
-
- Description:
- Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....
- Keyword:
- Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1
- Subject:
- Molecular biology, Medicine, and Neurosciences
- Creator:
- Murnan, Kevin Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864
-
- Description:
- Numerous insights into the sensorimotor systems that guide the control of voice have been garnered by observing how the system responds to manipulations of its auditory feedback. However, current approaches may be limited in the exploration of more complex parameters of volitional and adaptive voice control due to their limited...
- Keyword:
- Auditory Feedback, Sensorimotor Neuroscience, Systems and Cognitive Neuroscience, Speech Motor Control, Attention and Working Memory, and Vocal Control
- Subject:
- Cognitive psychology and Neurosciences
- Creator:
- Kim, Jason H
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15952 and etdadmin_upload_882078
-
- Description:
- Sensorimotor integration is a general term to describe how task-specific motor output is generated from the selective and rapid processing of sensory and motor information. The rodent vibrissal (whisker) system is an important model for the study of sensorimotor integration and active tactile sensing. This research uses the rodent vibrissal...
- Keyword:
- whisker, multi-whisker responses, trigeminal brainstem, vibrissa, multivibrissal stimulation, and tactile
- Subject:
- Neurosciences
- Creator:
- Dorizan, Schnaude
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_879050 and http://dissertations.umi.com/northwestern:15928
-
- Description:
- Electrical spinal cord stimulation is an emerging treatment for spinal cord injury that can improve walking and bladder control, among many other functions. While the anatomical location of the motor pools for muscles involved in locomotion in the lumbosacral cord has been identified, the map of the functional output of...
- Subject:
- Neurosciences
- Creator:
- Patterson, Jacqueline
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16163 and etdadmin_upload_917878
-
- Description:
- The current view in neuroscience holds that the brain, together with its sensory and motor structures and the environment, form a closed-loop system – a sensorimotor loop – in which the brain receives information from the environment and converts it into a motor response while simultaneously making predictions about future...
- Subject:
- Biomedical engineering, Computer science, and Neurosciences
- Creator:
- Zweifel, Nadina Olivia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16198 and etdadmin_upload_925059
-
- Description:
- Affect represents a major domain of human consciousness, consisting of a complex group of psychophysiological processes to drive human behavior. Many genetic and environmental factors may cause dysregulation of affective states, resulting in disorders that severely disrupt normal cognitive function and diminish the quality of life. Transitions among affective states...
- Keyword:
- Dopamine, Optogenetics, and Affective disorders
- Subject:
- Neurosciences
- Creator:
- Wu, Mingzheng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_925290 and http://dissertations.umi.com/northwestern:16201
-
- Description:
- Cholinergic modulation of the brain cortex is critical for cognitive processes, and altered cholinergic modulation of the prefrontal cortex is emerging as an important mechanism of neuropathic pain. Despite the known sex differences in pain prevalence and perception, the precise nature of the mechanisms responsible for sexual dimorphism in chronic...
- Keyword:
- acetylcholine, cholinergic modulation, prefrontal cortex, and pain
- Subject:
- Neurosciences
- Creator:
- Jefferson, Taylor
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16249 and etdadmin_upload_928522
-
- Description:
- Persons with spinal cord injuries can use state-of-the-art brain-computer interfaces to control robotic arms. Despite this high-tech solution, their movements are slow and imprecise, much like those made by individuals who have lost proprioception, the sense of body position and movement. Intracortical microstimulation (ICMS) used to reactivate neural circuits in...
- Keyword:
- proprioception, stimulation, prosthetic, and sensory
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Sombeck, Joseph T
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_917097 and http://dissertations.umi.com/northwestern:16157
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