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- Description:
- Nilotinib is a highly effective tyrosine kinase inhibitor used to treat Chronic Myeloid Leukemia (CML). While nilotinib successfully treats CML, a common and serious side effect is development of nilotinib-induced arterial disease (NAD) even in patients without pre-existing risk factors. This side effect is not seen with imatinib, a CML...
- Keyword:
- vascular smooth muscle cells, nilotinib, induced pluripotent stem cells, CML, and endothelial cells
- Subject:
- Pharmacology
- Creator:
- Pinheiro, Emily
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1015403 and http://dissertations.umi.com/northwestern:16792
-
- Description:
- G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in humans and play a role in nearly all physiological processes. Among GPCRs, metabotropic glutamate receptors (mGluRs) are a structurally distinct family of synaptic receptors that are essential in regulating neurotransmission and synaptic plasticity. Due to their important regulatory...
- Keyword:
- structural dynamics, mGluRs, conformational dynamics, membrane proteins, smFRET, and GPCRs
- Subject:
- Pharmacology, Biochemistry, and Biophysics
- Creator:
- Liauw, Brandon Wey-Hung
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_937523 and http://dissertations.umi.com/northwestern:16310
-
- Description:
- The airway epithelial cells (AECs) lining the conducting passageways of the lung secrete a variety of immunomodulatory factors. One interesting pair of molecules produces by AECs is IL-6 and prostaglandin E2 (PGE2). PGE2 limits lung inflammation and promotes bronchodilation. By contrast, IL-6 drives intense airway inflammation, remodeling, and fibrosis. The...
- Keyword:
- Airway Epithelial Cells, Purinergic Signaling, Interferon, and CRAC channels
- Subject:
- Pharmacology and Immunology
- Creator:
- Kountz, Timothy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15956 and etdadmin_upload_883223
-
- Description:
- Chemokines, such as Stromal Derived Factor 1 (SDF-1 or CXCL12) and their G protein coupled receptors (GPCRs) are well known regulators of the development and functions of numerous tissues. CXCL12 has two receptors: CXCR4 and CXCR7 or atypical chemokine receptor 3 (ACKR3). CXCR7 has been described as an atypical “biased”...
- Keyword:
- CXCR4 and CXCR7
- Subject:
- Pharmacology and Neurosciences
- Creator:
- Hopkins, Brittany E
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15737 and etdadmin_upload_844430
-
- Description:
- The protein homeostasis (proteostasis) network, a critical cytoprotective system that restores homeostasis in response to molecular stress, comprises distinct pathways, including the heat-shock response, unfolded protein response, oxidative stress response, and autophagy. These distinct pathways are all co-opted by tumor cells to cope with cancer-associated stress, and their activation in...
- Subject:
- Pharmacology, Genetics, and Biology
- Creator:
- Brockway, Sonia Susan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_780926 and http://dissertations.umi.com/northwestern:15412
-
- Description:
- Store-operated Ca2+ entry through Orai1 channels mediate transcriptional, proliferative, and effector cell programs in many cells and are activated through a unique inside-out mechanism involving binding of the endoplasmic reticulum Ca2+ sensor, STIM1, to cytoplasmic sites on Orai1. Mutations in Orai1 that block channel activation or evoke constitutive channel activity...
- Keyword:
- Orai1, Gating, STIM1, Channel, CRAC, and Calcium
- Subject:
- Pharmacology, Biology, and Biophysics
- Creator:
- Yeung, Priscilla See-Wai
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_622219 and http://dissertations.umi.com/northwestern:14422
-
- Description:
- In mature neurons, postsynaptic NMDARs are segregated into two populations, synaptic and extrasynaptic NMDARs, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR content (NMDAR-plasticity). Here, we identify the phosphorylation of the PDZ-ligand of...
- Keyword:
- NMDAR, NMDAR-plasticity, Extrasynaptic NMDAR, GluN2B, and PP1
- Subject:
- Pharmacology and Neurosciences
- Creator:
- Chiu, Andrew Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_669024 and http://dissertations.umi.com/northwestern:14717
-
- Description:
- Investigating the drug response at the transcriptional level is powerful for understanding the mechanism of drug adverse effects, elucidating inter-individual drug response variability and developing personalized therapies. However, drug perturbation experiments are limited to immortal cell lines which do not reflect the true physiology and gene expression of the liver,...
- Keyword:
- crd18
- Subject:
- Pharmacology
- Creator:
- Yizhen Zhong
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 04/05/2018
- Date Modified:
- 04/05/2018
- Date Created:
- 2018-04-02
- Resource Type:
- Poster