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- Description:
- Polymer nanocomposites have attracted great interest in recent years because of their potential as tailored materials with enhanced properties. Recent experiments have shown that polymer nanocomposites are able to achieve significant improvement in dielectrical, thermal, mechanical and other physical properties compared with their parent polymer systems. More importantly, these outstanding...
- Keyword:
- polymer nanocomposite, simulation, machine learning, optimization, database, and data mining
- Subject:
- Mechanical engineering
- Creator:
- Wang, Yixing
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_685582 and http://dissertations.umi.com/northwestern:14811
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- Description:
- Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are non-selective cation channels expressed in the brain and heart where they exert control over many diverse physiological properties. In the hippocampus, HCN channels are enriched in a dendritic gradient within CA1 pyramidal cells where they reduce dendritic integration and dampen neuronal excitability. HCN channels...
- Keyword:
- Temporal Lobe Epilepsy, HCN channels, Phosphorylation, and TRIP8b
- Subject:
- Neurosciences
- Creator:
- Foote, Kendall Marie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_682272 and http://dissertations.umi.com/northwestern:14781
-
- Description:
- The vaudeville remains an oft-overlooked genre of French song that was popularized by Paris’s fairground theaters and street singers on the Pont Neuf. Many histories of French music point to the middle of the eighteenth century as the period when the vaudeville began its rapid disappearance from the city’s musical...
- Keyword:
- French Revolution, French popular song, France, vaudeville, théâtre de société, and timbres
- Subject:
- French literature, Theater history, and Music history
- Creator:
- Harmon, Jenna M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14645 and etdadmin_upload_662497
-
- Description:
- Prior studies about restatements generally examine outcomes under assumed auditor responsibility. Surprisingly, however, about 20% of the restatements obtained from Audit Analytics correspond to cases where the current auditor was not engaged during the misstatement period. I refer to these cases as uninvolved. The first chapter examines current literature findings...
- Keyword:
- misstatement announcements, audit outcomes to restatement, market reaction to restatement, audit firm independence, and audit firm reputation
- Subject:
- Accounting
- Creator:
- Gomez, Pedro Enrique
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14607 and etdadmin_upload_661490
-
- Description:
- Decision making is an essential and indispensable element in everyday life. It is posited that parallel, distinct systems subserving deliberative, goal-directed control and automatic, habitual control underlie decision making. Computational accounts suggest that model-based and model-free learning strategies give rise to these two systems respectively. The model-based system is a...
- Keyword:
- Reward, fMRI, and Decision making
- Subject:
- Neurosciences
- Creator:
- Zhong, Wanting
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14552 and etdadmin_upload_647965
-
- Description:
- For years, neuroscientists have strived to understand memory consolidation, where salient memories are sorted and organized into distributed cortical networks for long-term storage. A large body of sleep research suggests that slow-wave sleep is an optimal opportunity for memory consolidation, and that consolidation is driven, at least in part, by...
- Keyword:
- olfactory reactivation, functional MRI, slow-wave sleep, ventromedial prefrontal cortex, memory replay, and memory consolidation
- Subject:
- Neurosciences
- Creator:
- Shanahan, Laura Kathleen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14493 and etdadmin_upload_634332
-
- Description:
- This thesis deals with modeling long-term deformation and failure of concrete and shale structures. First concrete structures are studied. For concrete structures, design lifetime of over a hundred years is required. Shrinkage, swelling, creep and Alkali-silica reaction are significant parts of the long-term deformation of concrete and are studied here....
- Keyword:
- Alkali-Silica Reaction, Creep and Shrinkage, Branching of Hydraulic Cracks, Microprestress, Creep of Shale, and Cement Hydration
- Subject:
- Geophysics, Computational physics, and Civil engineering
- Creator:
- RAHIMI-AGHDAM, SAEED
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14537 and etdadmin_upload_640235
-
- Description:
- Complex fluids are ubiquitous, from natural materials to manufactured products. Understanding their behavior under flow is vital for engineering these materials. Extensional flow, despite being industrially relevant and often producing dominant impacts upon complex fluids, is an underserved topic compared to shear flow due to a lack of reliable apparatuses...
- Keyword:
- cross-slot flow, carbon nanotube suspension, wormlike micelle, x-ray scattering, planar extensional flow, and lamellar surfactant
- Subject:
- Chemical engineering
- Creator:
- Luo, Binbin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_624324 and http://dissertations.umi.com/northwestern:14431
-
- Description:
- This dissertation develops a new framework and algorithms for statistical process control of stochastic textured surface data that have no distinct features other than stochastic characteristics that vary randomly (e.g., image data of textiles or material microstructures and surface metrology data of metal parts). All methods are general and nonparametric...
- Keyword:
- Industrial Statistics, Anomaly Detection, Defect Detection, Supervised Learning, Quality Engineering, and Image Dissimilarity
- Subject:
- Industrial engineering
- Creator:
- Bui, Anh Tuan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_680004 and http://dissertations.umi.com/northwestern:14772
-
- Description:
- Polymer nanocomposites are a class of advanced materials comprised of soft polymer matrix and nano-filler inclusions. While it has been found qualitatively that enhancements of material properties could be achieved by dispersing inorganic nano-particles into organic polymer matrix, the intrinsic governing principles of such composite has not been thoroughly studied...
- Keyword:
- Interphase, Data Mining, Design Optimization, Finite Element Analysis, Deep Learning, and Microstructure Characterization and Reconstruction
- Subject:
- Mechanical engineering, Computer science, and Engineering
- Creator:
- Li, Xiaolin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14436 and etdadmin_upload_625304
-
- Description:
- Solvent-rich polyelectrolyte complexes display a wide range of rheological properties, when different environmental parameters are applied. Due to the low energy barrier of the complexation (~10 kT), these materials possess tunable properties, with the states of these materials varying from Newtonian liquids to very tough hydrogels. This thesis aims to...
- Keyword:
- polyelectrolyte, thermo-thickening, fracture, gels, and viscoelasticity
- Subject:
- Materials Science
- Creator:
- Chen, Yaoyao
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_662844 and http://dissertations.umi.com/northwestern:14666
-
- Description:
- NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL). Cells harboring this mutation can become the predominant clone in relapsing disease. We studied the effects of this mutant enzyme...
- Keyword:
- oncology, acute lymphocytic leukemia, histone post-translational modifications, epigenetics, and cancer genetics
- Subject:
- Molecular biology, Oncology, and Cellular biology
- Creator:
- Swaroop, Alok
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14456 and etdadmin_upload_626665
-
- Description:
- Some of the oldest drugs targeting metabolism are the antifolates such as aminopterin and methotrexate (MTX). MTX started being used in the 1950s to treat rheumatoid arthritis. Aminopterin and MTX both target one carbon metabolism and inhibit proliferation of cells. MTX was a potent inhibitor of inflammation, because it prevented...
- Keyword:
- macrophage, LPS, glutathione, metabolism, inflammation, and serine
- Subject:
- Biology
- Creator:
- Rodriguez, Arianne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_638528 and http://dissertations.umi.com/northwestern:14513
-
- Description:
- Connecting structure and function in nanoscale engineered materials and devices relies on the analysis of the fundamental arrangement of matter, frequently under dynamic conditions. The demand to image structures at fundamental length scales has touched inorganic materials, biology, and frequently hybrid hard/soft materials with unique phenomena driven by heterogeneous components....
- Keyword:
- Imaging, Materials Imaging, Soft Materials, Crystallography, Machine Learning, and Electron Microscopy
- Subject:
- Nanoscience, Materials Science, and Computer science
- Creator:
- Hujsak, Karl
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14515 and etdadmin_upload_638887
-
- Description:
- Cancer radiation therapy relies on optimized treatment plans whose quality assessment is judged by dosimetric planning aims. It is computationally prohibitive to incorporate the planning aims into the optimization models. Therefore, there exists a disconnect between the two steps of (1) optimizing a plan and (2) evaluating the optimized plan,...
- Keyword:
- Planning Aims, Robust Optimization, Data Driven, Radiation Therapy, and Knowledge Driven
- Subject:
- Industrial engineering and Operations research
- Creator:
- Shojaei, Sayyedeh Nastaran
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14806 and etdadmin_upload_685183
-
- Description:
- In this dissertation, we study different machine learning algorithms including probabilistic, sparse and deep learning based models applied to multi-sensory datasets. In many machine learning problems, samples are collected from more than one source or modality. Also, various feature extraction methods can be used to provide more than one set...
- Subject:
- Computer science
- Creator:
- Rohani, Neda
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14441 and etdadmin_upload_625710
-
- Description:
- Children are known to be curious and persistent question-askers. The pervasiveness of voice interfaces represents an opportunity for children who are still learning to read and write to independently search the Internet by directing questions at conversational agents such as Amazon’s Alexa, Apple’s Siri, and the Google Assistant. However, little...
- Keyword:
- question-asking, voice assistants, conversational agents, and children
- Subject:
- Information science, Developmental psychology, and Communication
- Creator:
- Lovato, Silvia B
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_662479 and http://dissertations.umi.com/northwestern:14643
-
- Description:
- The Controlled, Site-Isolated Synthesis of Polyelemental Nanostructures in Polymer Nanoreactors Pengcheng Chen Polyelemental nanoparticles are an attractive class of materials due to their potential applications, which span the fields of catalysis, plasmonics, electronics, magnetics, targeted drug delivery, and bio-imaging. However, conventional synthetic methods for such structures are limited, especially when...
- Keyword:
- Nanostructures, Catalysis, Nanoparticles, Polyelemental, Nanoreactors, and Polymer
- Subject:
- Inorganic chemistry, Chemistry, and Materials Science
- Creator:
- Chen, Pengcheng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14466 and etdadmin_upload_627177
-
- Description:
- This thesis focuses on the development of a cochlear implant (CI) that uses photons to stimulate surviving auditory neurons in severe-to-profoundly deaf individuals. The benefit of optical over electrical stimulation is its spatial selectivity with the potential to create significantly more independent channels to encode acoustic information and likely enhances...
- Subject:
- Audiology, Psychology, and Neurosciences
- Creator:
- Xu, Yingyue
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14587 and etdadmin_upload_660188
-
- Description:
- Conventional methods in industrial organization assume that firms are strategically sophisticated and set prices as best responses to their competitive environment. In the first two chapters of this dissertation, I use a detailed dataset of retail and wholesale prices from the newly legalized cannabis industry in Washington state to show...
- Keyword:
- Optimal Pricing, Rule-of-thumb Pricing, Product Samples, New Markets, and Upstream Links
- Subject:
- Economics
- Creator:
- Escudero, Manuel Matias
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14609 and etdadmin_upload_661657