This thesis encompasses the work on bid-price controls for network revenue management and a dynamic model of revenue management with strategic consumers. The first line of research studies the circumstances under which bid-price controls are optimal or near optimal with minimal assumptions on the network topology and the stochastic structure...
The finite element method is used to investigate failure mechanisms in pin-hanger connections in aging highway bridges. Bridge pins and hangers are typically considered as critical elements whose failure may result in partial or entire collapse of the structure. The primary function of a pin-hanger connection is to allow for...
Mixed emotions, defined as the experience of having positive and negative emotions concurrently, can occur in a variety of consumer contexts, ranging from common consumption episodes to important life events. However, while there have been many studies demonstrating the occurrence of mixed emotions, little is known about the downstream consequences...
Particulate methane monooxygenase (pMMO) is a membrane-bound metalloenzyme that oxidizes methane to methanol in methanotrophic bacteria. The nature of the pMMO active site and the overall metal content are controversial, with spectroscopic and crystallographic data suggesting the presence of a mononuclear copper center, a dinuclear copper center, a trinuclear center,...
There is a growing interest in both marketing and economics in the dynamics of decision-making. Researchers have proposed richer behavioral models of consumers and firms with the purpose of learning behavioral primitives that static models cannot capture. In these studies, models move away from stylized views of decision-making by explicitly...
The extensive amount of maintenance expenditures on transportation infrastructure systems and their broad impacts in terms of economic and social development has emerged the interests in maintenance management of transportation infrastructure systems. This dissertation contributes an optimization framework for management of transportation systems that comprise of interdependent facilities.
Existing stochastic,...
Hedge funds' existence and activity have a dramatic impact on both financial markets and the real economy. The first chapter of this thesis analyzes the tradeoff between access to financing and disclosure of valuable trading information hedge funds are facing when interacting with their brokers. The next two chapters model...
This study examines how Cape Verdean theatre artists construct transformative performances of race, gender, language, and colonial history at the Mindelact International Theatre Festival on the Cape Verde Islands. The aim is to understand how international theatre festivals participate in the production and shaping of new social imaginaries about nationhood....
Autism spectrum disorders (ASD) is a highly heterogeneous and pervasive developmental disorder that affects nearly 1 in 150 children. A primary indicator of ASD is behavioral language impairment with respect to social communication, but the neurophysiology behind this impairment is not well understood. Both the perception and production of prosody...
Process scaling has enabled the production of integrated circuits with millions of transistors. System-on-a-Chip becomes feasible as more functionalities can be packed into a single chip. As the human brain power is limited, the design process of such sophisticated systems should be automated in order to meet the stringent design...
The rat whisker (vibrissal) system provides rats with an exquisitely acute tactile sense that has helped allow them to thrive all over the world. By actively rotating their whiskers back-and-forth ("whisking") against objects, rats can extract a rich variety of information including position, size, shape, orientation and texture. Today, however,...
I study the problem of choice between two treatments for a population of observationally identical individuals based on statistical evidence about average treatment effects that does not reveal the best treatment with certainty. I approach the problem from the perspective of statistical decision theory, derive treatment rules that minimize maximum...
In the last two decades the number of innovative applications for advanced materials has been rapidly increasing. Shape memory alloys (SMAs) are an exciting class of these materials which exhibit large reversible stresses and strains due to a thermoelastic phase transformation. SMAs have been employed in the biomedical field for...
Teasing is commonplace in our social interactions (Kowalski, 2007). Due to its paradoxical nature it can be employed to produce both positive and negative outcomes (Keltner et al., 1998) however, the ambiguity and subjectivity in teasing can make it susceptible to misinterpretation (Kowalski, 2000; 2007; Kruger et al., 2006). The...
This dissertation studies the management of operations that match surplus inventory of one party to meet the need of another. The first part is concerned with the efficient and robust design of transshipment networks in a commercial environment. The second part is concerned with a sequential resource allocation problem in...
Generalized extreme value (GEV) models provide a convenient way to model choice behavior that is consistent with utility maximization theory, but the development of specific new models within the GEV family has been slow, due to the difficulty of ensuring new formulations comply with all the GEV rules. The network...
The work presented here describes investigations into the interaction of resonant molecules with metallic nanoparticles by localized surface plasmon resonance (LSPR) spectroscopy. The contents of this thesis include the study of the coupling mechanism between molecular resonance and plasmon resonance from experimental and theoretical perspectives and applications of this mechanism...
Late twentieth-century architecture is increasingly charged with the task of constructing sites of meaning that generate awareness and understanding in the wake of catastrophic historical events. My dissertation explores the challenges of memorializing these events, in order to recover the importance of memory for politics. Insisting on the role of...
This dissertation consists of three empirical essays on issues related to Internet-based firms entering the offline channel. Issues arising from offline entry include the potential spillovers in online revenue, online customer acquisition, and online customer activity. Over the past decade, there has been considerable research examining brick $\&$ mortar companies...
The world's aquatic food webs are currently in crisis due to the cumulative, interacting effects of anthropogenic pressures including non-indigenous species invasions, chemical contamination, overfishing, habitat disruption and global climate change. Efforts to restore or protect the integrity and sustainability of these systems are limited by a lack of knowledge...
Racial disparities in cardiovascular health constitute one of the most pressing current public health problems in the United States. This dissertation examines how individual's cultural experiences of stress become embodied and contribute to these racial health inequalities. Anthropologists have traditionally approached culture through narrative ethnographic methods that are difficult to...
The growing technological industry is demanding the development of powerful and smaller devices. Dielectric thin-films can play an important role to help push towards achieving these goals. However, their advantage of high-quality material and low material costs compared to bulk can only be achieved with consideration of the technique, conditions,...
Learning to play an instrument requires the progressive tuning almost all of a student's senses. He trains his ears to hear consonance and dissonance and eyes to read sheet music or read other musicians' body language, for example. The protracted training that is required to become a musician has been...
The average and local glass transition temperatures (Tgs) and physical aging behavior of various confined polymers were studied in order to gain an understanding of these surface/interface effects and their propagation into the polymer. Using a novel multilayer/fluorescence method, the Tgs of layers at the free surface, substrate-polymer interface, and...
The early transition metal oxide fluoride molecular anions with the general formula [MOxF6-x]n- with x = 1 for M = V5+, Nb5+, Ta5+ (n = 2) and x = 2 for M = Mo6+, W6+ (n = 2) feature distorted octahedral coordinations, that arise from electronic dπ pπ metal oxide...
Biological fouling of surfaces is problematic for many medical applications because proteins, cells and bacteria can impair the function of devices and lead to catastrophic complications. Numerous strategies exist for reducing fouling in physiological environments; the strategy described in this thesis focuses on the modification of substrates with poly-N-substituted glycine...
Plants, animals, and yeast have the capacity to produce and accumulate neutral lipids, sterol esters and triacylglycerol (TAG). However, their accumulation and the genes underlying their synthesis in intracellular microorganisms are poorly understood.
Plasmodium falciparum is a parasitic protozoan that causes the most virulent form of human malaria. During erythrocytic...
Novel materials and nanostructures with superior electro-mechanical properties are emerging in the development of novel devices. Engineering application of these materials requires accurate electro-mechanical characterization, which in turn requires development of novel experimental techniques. This dissertation outlines the investigation of the mechanical and electrical properties of one-dimensional nanomaterials.
One-dimensional nanomaterials...
As Wilfrid Sellars put it, one of the principal aims of philosophy "is to understand how things in the broadest possible sense of the term hang together in the broadest possible sense of the term." In this I think Sellars is right: the discipline is charged with taking a "synoptic...
This dissertation examines the participation of tens of thousands of African-American servicemen in the occupation of Japan and the Korean war. It poses three questions: how were black servicemen incorporated into a postwar military empire; how did they help shape their nation's expanding Asian protectorate; and how did they understand...
In Muslim West Africa, food-producing villages also produced literate scholars. This study examines how such unlikely intellectuals acquired and gave meaning to Islamic knowledge through one village's experience from 1900 to the 1960s. Unlike the colonial sources underlying conventional approaches to West African Islam, libraries and oral sources from Ruumde...
The purpose of this mixed methods study was to learn about the ways that instrumental music teachers in Chicago navigate the urban landscape. The design of the study most closely resembles Creswell and Plano Clark's (2007) two-part Triangulation Convergence Mixed Methods Design, with the addition of an initial exploratory focus...
We consider two problems in low Reynolds-number, interfacial fluid mechanics: the rupture of thin liquid films on chemically patterned solid substrates, and the engulfment of foreign particles by a solidification front progressing through a binary alloy.
First we investigate the stability and rupture of thin liquid films on patterned sub-...
This dissertation formulates, solves and estimates dynamic stochastic games to answer various questions that arise in Industrial Organization. First chapter is a "theoretic" investigation of learning-by-doing and organizational forgetting that shows them to be distinct economic forces whose interplay gives rise to aggressive pricing behavior, market dominance, and multiple equilibria....
In this dissertation we analyze the decision process of firms and individuals along two dimensions which are central to the field of asset pricing and macroeconomics. In the first chapter, we study the pricing decision of the firm in a framework where customer base matters. Surveys of managers show that...
B_s mixing studies provide a precision test of Charge-Parity violation in the Standard Model. A measurement of deltaMs constrains elements of the CKM quark rotation matrix, providing a probe of Standard Model Charge-Parity violation.
This thesis describes a study of B_s mixing in the semileptonic decay B_s -> D_s mu...
This study examines rhetorical practices through which disenfranchised women developed tenable political identities and integrated themselves into the public realm in the Pacific Northwest between 1868 and 1912. Through close analysis of rhetorical activities in which thousands of women participated--including club discourse, public commemoration, legal advocacy, petition work, and publication--it...
Embryonic stem cells have the potential to differentiate into ectodermal, mesodermal and endodermal derivatives. This property makes them a valuable source of tissue specific progenitor and differentiated cells that can be used for cell replacement therapy. The first goal of this thesis is to test if cardiogenesis from embryonic stem...
Rare events are studied in an increasing number of areas, ranging from lightwave and optical communication systems, to industrial routing problems, to rogue ocean waves, to financial asset pricing, to the rare failure of something as common as Gaussian elimination, as well as numerous others. In optical communication systems, a...
The homotopy groups of bo^tmf are shown to be isomorphic to the homotopy groups of a wedge of suspensions of spectra related to integral Brown-Gitler spectra. We will then restate Mahowald's proof of the topological splitting of bo^bo and subsequently apply similar techniques to construct a map that realizing the...
The human brain shows great flexibility to adjust itself to dynamically ever-changing environment. Despite more than 100 years of cognitive brain research, the dynamical aspect of cognitive process has remained poorly understood compared to the static aspect of that. This dissertation concerns the dynamic character and functional significance of periodically...
Eukaryotic gene transcription is a coordinated process involving the participation of a large number of proteins. Sequence-specific DNA-binding transcription factors function as activators or repressors of transcription and frequently recruit transcriptional coregulators that lack specific DNA-binding activity. These multi-protein complexes with intrinsic chromatin-modifying and chromatin-remodeling activities have emerged as key...
We use transverse sound spectroscopy to probe excited states of the Cooper pairs in the B-phase of superfluid 3He. In particular we study those excited states with non-zero energy at zero momentum, the so called gapped, or exciton, modes. This includes precise measurements of the imaginary squashing mode energies as...
Both individual and institutional investors face a number of constraints in their consumption and investment decisions. We look at well-motivated constraints on the consumption process as well as liquidity constraints and study their impact on optimal consumption and investment policies under a dynamic discrete time setting.
The use of composites is increasing as they afford scientists and engineers the ability to combine the advantageous properties of each constituent phase, e.g. metal ductility and ceramic stiffness. With respect to materials design, biomimetics is garnering increasing attention due to the complex, yet efficient, natural microstructures. One such biomimetic,...
My primary interest is in markets as aggregators of information. To study this I create a benchmark market-microstructure model of sequential trading on posted prices. I have a competitive market maker and rational profit-maximizing traders with different tastes over a single asset and heterogeneous information over its value. The differences...
A dynamic model of the rolling process that includes the material strain-hardening and work roll flattening effects was developed based on homogeneous deformation theory. By coupling this new dynamic rolling process model with a structural model for a mill stand, a single-stand chatter model expressed through a state-space representation was...
Visual object tracking, i.e. consistently inferring the motion of a desired target from image sequences, is a must-have component to bridge low-level image processing techniques and high-level video content analysis. This has been an active and fruitful research topic in the computer vision community for decades due to both its...
This dissertation analyzes how individuals choose college majors. The choice of college major is treated as one made under uncertainty. Understanding any decision under uncertainty requires one to study how expectations and preferences are used to make the choice. However, since observed choices may be consistent with many combinations of...
The automobile coating industry is undergoing reformation driven by environmental regulations that demand low content of volatile organic compounds. Traditional solvent-borne acrylic resins
consisting of high molecular weight polymers that are produced at low temperatures (< 80 C) need high levels of organic solvent (70%) to be processed as coatings....
Copper serves as a cofactor for many proteins and enzymes involved in important biological processes, but at the same time, excessive copper is toxic to cell. Thus, the intracellular copper concentration must be tightly controlled such that copper is provided to essential enzymes but does not accumulate to toxic levels....
Finite element methods for the simulation of dynamic fracture in plane and thin shell structures and their application to quasi-brittle fracture problems are presented. The method is based on the extended finite element method (XFEM) and is incorperated within an explicit time integration scheme. The method is implemented using 4-node...
A current challenge to the civil/environmental engineering field is to assist full-scale wastewater treatment facilities through wider use of advances in modeling methods and analytical techniques. To address this challenge I applied modeling tools and, with assistance, the molecular biology analytical method of Fluorescent In-Situ Hybridization (FISH) to the high...
Consumers' willingness-to-pay can change over time and can change differently for different consumers. Rational and forward-looking consumers incorporate this into their decision making. This dissertation examines the implication of such change in several dynamic IO settings.
The first chapter looks at a durable goods monopoly setting where consumers' valuations decline...
This dissertation focuses on the contribution of Joseph Addison and his London newspaper The Spectator to the modern "social imaginaries" (Charles Taylor) of public, market and nation. Addison's championing of perspicacity in prose and detachment in aesthetic judgment created protocols of "stranger sociality" (Michael Warner) that made participation in these...
How can political challengers avoid co-optation and other forms of moderation? This dissertation illuminates how institutional participation led to the co-optation of the Indigenous Australian movement and the factors which equipped the Ecuadorian Indígena movement to elude a similar fate. Most contestants in political struggles must at some point consider...
This dissertation analyzes the transformation of fantasy sports from a deviant, outside-the-mainstream fan culture to a billion-dollar industry that comprises almost 20 million North American participants. Fantasy sports are games in which participants adopt the simultaneous roles of owner, general manager, and coach of their own teams of real athletes...
A major challenge in the field of Structural Health Monitoring (SHM) of safety-critical structures is how to effectively and efficiently detect fatigue damage, especially before there is macrocrack initiation. In this dissertation, a local ultrasonic technique is developed to assess pre-crack fatigue damage in structures. The novel feature of this...
Despite three decades of intense research into small diameter blood vessel tissue engineering, constructs developed to date lack the elastin necessary for long term patency and the prevention of aneurysms. The suboptimal biochemical composition suggests that new biochemical and mechanical culture methods must be developed. In addition, current biomaterials for...
PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
Consumption of CO2 by chemical weathering is one of the major fluxes in the global carbon cycle that drives long-term climate. In an effort to understand silicate weathering, which is a net sink of CO2 over geological time scales, as a function of environment (e.g., exposure of parent rocks, climate,...
This dissertation addresses the structure of the group of interval exchange transformations. The two primary topics considered are:
a) the classification of interval exchange actions for certain groups; and b) properties of the interval exchange group which are reflected in the dynamics of interval exchange maps.
In Chapter 3 a...
This dissertation examines performance and textual techniques used by American and British artists to provoke discussion about the politics of viewing. I theorize a model of spectatorship which exposes the race and gender symbolism of actors' and spectators' bodies and its effects on meaning-making in the performer-spectator encounter. In contrast...
Although anxiety and depression are clearly distinct from a phenomenological perspective, discriminating these constructs empirically has often been difficult (Clark & Watson, 1991). Both the tripartite model of psychopathology (Clark & Watson, 1991) and the cognitive content-specificity hypothesis (Beck, 1976; Beck & Clark, 1988) were forwarded in an effort to...
This dissertation constitutes a re-evaluation of the popular and critical understanding of eighteenth-century libertinage. In particular, I contest the distinction between sentimentalism and libertinage, which are typically seen as two, irreconcilable approaches to emotional expression. As sentimentalism became prominent in the second half of the eighteenth century, I argue, it...
Researchers have long recognized that schools are powerful environments for shaping students' worldview and identity. The structured content, activities, and resultant culture of schools profoundly impact the way in which students learn to make sense of the world around them. In the ultra-Orthodox Jewish community this function of schooling is...
This project argues that displays of humanist learning in diplomacy served to demonstrate the extraordinary good will of the Florentine regime towards a host ruler. I call this act of surpassing previous oratorical gestures a "cultural gift". Although the singular goal of humanism in diplomacy remained offering cultural gifts in...
The use of cluster randomized experiments to study the effects of treatments on groups of subjects has increased in recent years. Many of these experiments lack the necessary statistical power to detect practically meaningful effects of treatment. One method for improving power in cluster randomized experiments that has been advanced...
We present several multiscale quantum mechanical (QM), molecular mechanical (MM), and continuum mechanical (CM) schemes to study the strength properties of carbon nanotubes (CNTs) and graphene sheets. A bridging domain method based on overlapping domain-decomposition schemes using the Lagrange multipliers field is developed to couple an atomistic domain with a...
The current trend of ceramic nanotechnology has motivated an ever-increasing need to achieve exquisite control over size, shape, and spatial confinement for functional oxide architectures, in an equivalent manner demonstrated for semiconductors. However, the unique nature of ceramics has posed major challenges for most traditional nanofabrication technologies, putting the development...
The proper distribution of cellular organelles and protein complexes is important for maintaining cellular organization and function. Transport in eukaryotic cells requires three motor proteins, kinesin, dynein, and myosin, attached to specific cargoes mostly by adaptor proteins. This work focuses on the mechanism of microtubule-dependent organelle transport in vivo.
This...
Integrated circuits have been continuously scaled to increase speed and integration density as a means to improve the performance or pack more functionality. However, an extremely enormous amount of effort is needed to further scale the dimensions in deep submicron technologies. As technology scaling is slowing down and design complexity...
Integrated circuits have been continuously scaled to increase speed and integration density as a means to improve the performance or pack more functionality. However, an extremely enormous amount of effort is needed to further scale the dimensions in deep submicron technologies. As technology scaling is slowing down and design complexity...
"How did the Civil Rights Movement bring about change?" In answer to that question, this dissertation argues that the splintering of purity rhetoric within the intimate environments of home and sanctuary both inhibited and empowered white and African-American religious practitioners to seek social change. To make this argument, this project...
The work of this dissertation was aimed at synthesizing new types of nanoparticle-DNA conjugates, investigating their chemical and physical properties, and exploring their biodiagnostic applications. Chapters Two and Three describe the synthesis of new types of nanoparticle-DNA conjugates: (1) silver nanoparticle-DNA conjugates (DNA-Ag NPs) and (2) 2-nm gold nanoparticle-DNA conjugates...
As manufacturing technology moves toward fundamental limits of silicon CMOS processing, it is increasingly important to utilize the full potential of available transistors and interconnects. While manufacturing technology faces fundamental limits inherent in physical laws or material properties, design and verification technology faces fundamental limitations inherent in the computational intractability...
In several neurodegenerative diseases, the microtubule-associated protein tau self-aggregates to form filaments that accumulate in neurons and/or glia, although the relationship between tau aggregation and cell death is a subject of debate. The amino terminus of tau is involved in conformational changes that appear critical for filament formation, hinting at...
Inactivation of tumor suppressors genes, which encode regulatory proteins critical for maintaining normal cellular function, is a common occurrence in cancer. Ikaros is a hematopoietic-specific zinc finger protein that functions as a differentiation regulator and has properties of a tumor suppressor. Ikaros functions to regulate gene expression as a component...
The set of experiments described here test the hypothesis that the declarative memory system supported by the medial temporal lobe and habit/procedural memory supported by the basal ganglia are recruited when learning novel category representations. The theory guiding specific hypotheses about these neural systems and their operation in category learning...
Organic light emitting diodes (OLEDs) are fabricated and characterized on anodes modified by a variety of surface treatments. OLED performance response is correlated to the treatment conditions with current-voltage (I-V) measurements and impedance spectroscopy. Small-scale OLED arrays are fabricated using a novel shadow mask approach and are characterized with electrical...
The electronic properties of various transparent conducting oxide (TCO) surfaces are probed electrochemically via self-assembled monolayers (SAMs). A novel graftable probe molecule having a tethered trichlorosilyl group and a redox-active ferrocenyl functionality (Fc(CH2)4SiCl3) is synthesized for this purpose. On as-received ITO, saturation coverage by a close-packed monolayer having of 6.6...
Despite its prevalence, cost, and association with high risk for negative outcomes, there is a lack of empirically-based procedures for effective treatment of dual diagnosis in adolescents. The present study attempts to address the need for research informing effective treatment of this population. Strengths have been found to predict positive...
This dissertation examines the role of market makers in making markets for options and futures on Chicago's derivatives exchanges. Recent institutional and technological changes in the ways that financial products are traded have given rise to the possibility of markets without market makers, raising the question of how these developments...
The primary purpose of this study was to describe what comprises an undergraduate compositional identity. Building upon recent research investigating musical identities with a social psychological framework (Macdonald, Hargreaves, & Miell, 2002), I examined the confluence of socially based experiences that shaped four undergraduate composers' lives. Specifically, this study investigated...
Lead poisoning is the most common environmentally-caused disease in the United States and is threat to human health worldwide. Although efforts to prevent lead exposure have increased throughout the years, lead poisoning still remains a common problem. Lead toxicity is more prevalent in children, who suffer from permanent neurodevelopment and...
Herpesviruses require axonal transport for the successful establishment of infection in peripheral ganglia (retrograde transport), and the subsequent spread to exposed body surfaces following reactivation from latency (anterograde transport). Viral progeny are assembled and spread to other tissues or hosts during egress. I focused on viral proteins which modulate directed...
Magnetic resonance imaging (MRI) is a technique widely used in both clinical and experimental settings to produce high-resolution images of opaque living organisms without utilizing ionizing radiation. Currently, MR imaging is augmented by contrast agents; however, these small molecule Gd(III) chelates are confined to extracellular and vascular regions of the...
Let X be a quasi-projective complex variety. It follows from the work of Voevodsky that the motivic cohomology of X, denoted as $H^{p,q}(X)$ where q and p are integers with q nonnegative, can be represented in the triangulated category of motives over the field of complex numbers, denoted as $DM^{eff,-}_{Nis}$....
Separation of DNA molecules by electrophoresis through entangled polymer solutions continues to be an important tool for genetic analysis, especially Sanger-based DNA sequencing. Separations of DNA on microfluidic devices are much more efficient than in capillary electrophoresis (CE) systems, such that the implementation of DNA sequencing onto microchips promises to...
This dissertation comprises three chapters, each focusing on a different question in economic theory. The first two chapters focus on repeated games and reputations, while the third is about large games. In "Cooperation and Community Responsibility", I study whether cooperation can be sustained between communities where members interact repeatedly but...
The small heat shock protein αB-crystallin is expressed primarily in lens and muscle tissue, but it is also found in lung, kidney and many cancers. Regulators of αB-crystallin have been identified almost exclusively using mouse muscle and lens specific models. It has been well documented that αB-crystallin is expressed in...
The first chapter of this dissertation studies a continuous-time agency model where the agent controls the drift of the geometric Brownian motion firm size. The changing firm size generates partial incentives, analogous to awarding the agent equity shares according to her continuation payoff. When the agent is as patient as...
One of the most commonly used techniques for classification problem is logistic regression. For example, logistic regression for a binary response assumes that the odds Pr(y = 1|x)/Pr(y = 0) = exp(a+bx). However, in reality, the pattern of the data can be so complicated that logistic regression model often fails,...
N-Heterocyclic carbene catalysis has recently emerged as an important field in organic chemistry. Two new strategies have been developed to advance the use of N-heterocyclic carbenes (NHCs) as Lewis-base organic catalysts. The first approach utilizes NHCs to catalyze the generation of homoenolates and the conjugated Breslow intermediate is added to...
Time-resolved in situ synchrotron x-ray scattering studies of particle orientation in polymer-clay nanocomposites under simple shear and complex flow were performed. Shear flow experiments used an annular cone and plate x-ray shear cell to allow measurement of platelet orientation within the flow-gradient plane.
Intercalated nanocomposites were made by dispersing organically...
Epstein Barr Virus (EBV) is associated with malignancies of lymphoid and epithelial origin. While the precise role of EBV in oncogenesis remains elusive, latent membrane protein 2A (LMP2A) is detected in all EBV-associated malignancies, implicating LMP2A in their pathogenesis. Interestingly, LMP2A is expressed in EBV-associated malignancies such as Burkitt's Lymphoma,...
Chapter one investigates the impact of agents' expectations about future fundamental economic disturbances (news) on macroeconomic dynamics. Several intuitive tests provide insight into the information content of the yield curve and its' ability to identify these 'news' disturbances. Bayesian estimation of a dynamic stochastic general equilibrium (DSGE) model using conventional...
Tonia René Holverson The HPV genome contains a bipartite promoter system that regulates the expression of early and late gene transcripts. The early proteins include the replication proteins E1 and E2, the oncoproteins E6 and E7, and the late functioning proteins E4 and E5. The late proteins include the capsid...
Estrogens are traditionally thought to act through a nuclear receptor-mediated mechanism to regulate gene transcription in target tissues. The hippocampus has been shown to be sensitive to estrogen; estrogen regulates GABAergic inhibition and spine density of dorsal CA1 pyramidal cells. However, very few neurons expressing nuclear estrogen receptors (ERs) have...
The kinetoplastid protozoan <em>Trypanosoma brucei</em> is the causative agent of African trypanosomiasis, affecting humans, and Nagana disease, affecting cattle, prevalent in regions of sub-Saharan Africa. Our lab demonstrated that the flagellum of <em>T. brucei</em> is enriched in lipid rafts, membrane areas composed of sphingolipids, sterols, and proteins that serve as...