The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
The language Esterel has found success in many safety-critical applications, from aircraft landing gear to digital signal processors. Its unique combination of powerful control operations, deterministic concurrency, and real time execution bounds are indispensable to programmer in these kinds of safety-critical domains. However these features lead to an interesting facet...
Biological organisms have the extraordinary ability to form mineral structures with unparalleled control. From curved single crystals to hierarchically structured skeletal parts, biomineralization processes produce materials with properties that are highly optimized for their intended applications. These processing techniques occur at ambient conditions using materials abundant in the environment, and...
This dissertation traces the intellectual and social history of slavery in the Lower Congo over the Longue Durée. It examines how Bantu-speaking groups of the Lower Congo inherited, constructed, reconstructed, and passed on to younger generations a vocabulary that framed their shifting slaving practices from their arrival in the region...
Simulation studies are virtually all motivated by decision making. Because simulation output is stochastic and input models are never perfect, all decisions should include an accounting for risks. Input model risk refers to the exposure due to imperfect simulation input models that are estimated from real-world data, involving both the...
This thesis provides an introduction to decay rates for the damped wave equation on compact manifolds. It also gives a proof of a sharp decay rate for solutions to the damped wave equation on the torus with damping of a particular polynomial form. Finally it gives a proof of a...
Classical conditioning is a form of associative learning and can be used as a behavioral paradigm to model and investigate the neural mechanisms underlying associative learning. In this work, classical conditioning paradigms are used to test the effectiveness of a disease model on the impact of learning and emotional regulation...
Histone methylation plays an important role as an epigenetic regulator, capable of driving stable, persistent changes in gene expression without changing a cell's genetic code. Previous work has used stable isotope labeling (SILAC) in combination with mass spectrometry to observe the relationship between the methylation of two neighboring lysine sites...
This dissertation examines the longue durée political history of Ateker-speaking agro-pastoralists in the semi-arid plains of today’s Uganda – Kenya – Ethiopia – South Sudan borderlands. Today’s Ateker-speaking communities include the Karimojong, Teso, Turkana, Toposa, Dodos, Jie, Nyangatom, and Jiye. Over the past millennium, Ateker-speaking communities developed a diversity of...
Abstract This dissertation studies a creative archive composed of poems, novels, performances, and visual art produced after 1990 that increasingly represent the ocean as “one salt water”: a space of relations among Indigenous oceanic peoples, animals, plants, and other beings. In doing so, these texts work to forge solidarities and...