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- Description:
- The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is implicated in active transcription. Here we show that DOT1L is overexpressed in Prostate cancer (PCa) and is associated with poor clinical outcome. Genetic and chemical inhibition of DOT1L selectively impaired viability of androgen receptor (AR)-signaling competent PCa...
- Keyword:
- Prostate Cancer, DOT1L, and Epigenetics
- Subject:
- Molecular biology and Oncology
- Creator:
- Vatapalli, Rajita
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14971 and etdadmin_upload_714534
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- Description:
- This work is composed of two separate projects that contribute to the field’s understanding of Neisseria gonorrhoeae genetics and physiology. First, I showed that N. gonorrhoeae mounts a substantial transcriptional program in response to hydrogen peroxide (HP), a prominent reactive oxygen species (ROS) encountered during infection. We measured which strain...
- Keyword:
- Bacterial genetics, Microbiology, Neisseria gonorrhoeae, and Bacteriology
- Subject:
- Microbiology
- Creator:
- Quillin, Sarah Jane
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14977 and etdadmin_upload_716337
-
- Description:
- The continued existence and use of chemical warfare agents (CWAs) have necessitated the development of materials which can safely and efficiently decontaminate these toxic chemicals in an environmentally benign fashion. Among the most prevalent CWAs, nerve agents (sarin, VX) and blistering agents (sulfur mustard [HD]) are considered the most toxic...
- Keyword:
- polyoxometalate, chemical warfare agent, oxidation catalysis, and metal-organic framework
- Subject:
- Inorganic chemistry
- Creator:
- Buru, Cassandra Terez
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15003 and etdadmin_upload_718951
-
- Description:
- The viscoelastic properties of microbial biofilms have attracted great interests in recent years due to the ubiquity of biofilms and their wide range of industrial and municipal applications causing tremendous societal impacts. Biofilms are predominantly architected by extracellular polymeric substances (EPS) matrices composed of bacterial cells and biopolymers secreted by...
- Keyword:
- Rheology, Optical coherence elastography (OCE), Nondestructive testing, Viscoelastic properties, Biofilms, and Wave propagation
- Subject:
- Environmental engineering, Mechanical engineering, and Acoustics
- Creator:
- Liou, Hong-Cin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_714259 and http://dissertations.umi.com/northwestern:14970
-
- Description:
- In this dissertation, we study models and methods to address uncertainties that can vary in optimization problems. Robust optimization is a popular approach for optimization under uncertainty, especially if limited information is available about the distribution of the uncertainty. It models the uncertainty through sets and finds a robust optimal...
- Keyword:
- variable uncertainty, optimization, decision dependent uncertainty, and robust optimization
- Subject:
- Industrial engineering and Operations research
- Creator:
- Sharma, Kartikey
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718511 and http://dissertations.umi.com/northwestern:14998
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- Description:
- Nucleic acid drugs promise to revolutionize the development of therapeutics. They offer a platform for digital medicine, where systematic changes to the nucleic acid sequence can be utilized to target the entire human genome. However, nucleic acids suffer from a number of drawbacks, such as negligible cellular uptake and rapid...
- Keyword:
- siRNA, Spherical Nucleic Acids, and High Throughput Analysis
- Subject:
- Nanotechnology, Nanoscience, and Biochemistry
- Creator:
- Yamankurt, Gokay
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14982 and etdadmin_upload_717353
-
- Description:
- Mineral inclusions in diamond, brought to the surface through kimberlitic eruptions, provide a unique glimpse into the geochemical inner workings of Earth’s deep interior. Diamonds source a wide range of depths in the mantle. While most diamonds originate from the upper 200 km of the Earth’s mantle, aptly called super-deep...
- Keyword:
- mineral, computed microtomography, diamond, radiography, microdiffraction, and microinclusions
- Subject:
- Geology
- Creator:
- Wenz, Michelle Dawn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_719066 and http://dissertations.umi.com/northwestern:15004
-
- Description:
- Episodic memory provides a means by which we reflect on the past, make decisions about the future, and form a learned identity. Episodic memory depends on the hippocampus as well as on the distributed set of regions that form a hippocampal-cortical network (HCN), including medial prefrontal, posterior cingulate, and medial...
- Keyword:
- memory, hippocampus, brain network, and stimulation
- Subject:
- Neurosciences
- Creator:
- Warren, Kristen N
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14985 and etdadmin_upload_717587
-
- Description:
- Skeletal muscle is one of the most abundant tissues in the body and makes up over 40% of the total body mass. It is important for mobility and posture maintenance as well as plays a central role in whole body metabolism. Skeletal muscle is made up of bundles of muscle...
- Keyword:
- Muscle plasticity, Genomics, ChIP-seq, and Muscle atrophy
- Subject:
- Molecular biology and Endocrinology
- Creator:
- Ramachandran, Krithika
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718262 and http://dissertations.umi.com/northwestern:14993
-
- Description:
- Dilute Al-Sc-Zr-Si-based aluminum alloys retain their strength for long periods of time at elevated temperatures due to a dispersion of nanometric, coherent, and coarsening-resistant Al3(Sc,Zr) (L12 structure) nanoprecipitates that are formed upon aging. These alloys are attractive for replacement of dense steels and costly Ti alloys in the 250–400 °C...
- Keyword:
- L12 nanoprecipitates, Atom-probe tomography, Coarsening, High-temperature alloys, Creep, and Aluminum alloys
- Subject:
- Materials Science
- Creator:
- Michi, Richard Andrew
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718569 and http://dissertations.umi.com/northwestern:14999