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- Description:
- Transcription is tightly regulated to ensure genes are appropriately expressed both temporally and spatially. This tight regulation governs various processes within the cell, such as differentiation and cell identity, cellular maintenance, and dynamic responses to external signals. Transcription factors (TFs) coordinate these various gene programs and in particular, are key...
- Keyword:
- Repressor, NAFLD, PPAR alpha, BCL6, Transcription, and Metabolism
- Subject:
- Molecular biology and Biology
- Creator:
- Sommars, Meredith Anne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_663025 and http://dissertations.umi.com/northwestern:14672
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- Description:
- This dissertation presents two projects with the goal of understanding how to quantitatively describe biological data, particularly data that is highly dynamic. The first study presents an improved quantitative tool for the analysis of particulate trajectories. Particulate trajectory data appears in several different biological contexts, and the majority of analyses...
- Keyword:
- Differential Equations Modeling, Quantitative Biology, Data Driven Methods, Jump Distance Distribution, and C. elegans
- Subject:
- Applied mathematics
- Creator:
- Menssen, Rebecca
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_684514 and http://dissertations.umi.com/northwestern:14797
-
- Description:
- Endothelial cells (ECs) require glycolysis for proliferation and migration during angiogenesis; however, the necessity for the mitochondrial respiratory chain during angiogenesis is not known. In this study, we report that inhibition of respiratory chain complex III impairs proliferation, but not migration of ECs in vitro by decreasing the NAD+/NADH ratio....
- Keyword:
- Angiogenesis and Mitochondria
- Subject:
- Cellular biology
- Creator:
- Diebold, Lauren P
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_622203 and http://dissertations.umi.com/northwestern:14421
-
- Description:
- Herpes simplex encephalitis (HSE) is a rare and severely debilitating life-threatening disease caused by herpes simplex virus type 1 (HSV-1) infection of the human central nervous system (CNS). The severe and often fatal outcomes of HSE contrast starkly with the more frequent and largely benign consequences of herpes labialis. Whole...
- Keyword:
- Herpes, PNS, Toll like receptors, TLR3, CNS, and Innate immunity
- Subject:
- Virology, Microbiology, and Immunology
- Creator:
- Ewaleifoh, Osefame
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14704 and etdadmin_upload_667366
-
- Description:
- Rhythmic oscillations in the brain are widespread. Extracellular recordings of local field potentials (LFPs) using methods ranging from microelectrodes to scalp electroencephalography (EEG) have demonstrated that oscillatory dynamics play a vital role in operations such as network synchronization, sensory tuning and information packaging. Empirical and computational evidence suggest that these...
- Subject:
- Neurosciences
- Creator:
- JIang, Han
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_641773 and http://dissertations.umi.com/northwestern:14545
-
- Description:
- Biomass has the potential to be our country’s leading renewable source of energy. Specifically, fast pyrolysis is a promising method for the conversion of biomass to valuable fuels and chemicals. Given that fast pyrolysis has a residence time of about two seconds, computational methods are particularly useful in obtaining product...
- Keyword:
- lignin structure, Markov Chain Monte Carlo, microkinetic model, zeolite, catalytic upgrading, and biomass
- Subject:
- Chemical engineering
- Creator:
- Dellon, Lauren
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_670422 and http://dissertations.umi.com/northwestern:14723
-
- Description:
- Quantum technologies have the capability of greatly increasing the security of communication systems. Many components are required for a full quantum network including memory, repeaters, routers, and detectors. The efficiencies of quantum communication technologies suffer greatly due to their inherent sensitivity to loss. Low-loss propagation and high detection efficiency can...
- Keyword:
- Photonics, Quantum optics, Nonlinear optics, and Upconversion
- Subject:
- Optics, Physics, and Electrical engineering
- Creator:
- Silver, Michael Lee
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_627388 and http://dissertations.umi.com/northwestern:14474
-
- Description:
- Newcomers, or new members to organizations or professions, bring insights that are critical to the advancement of society. Yet newcomers often have low self-efficacy, or low beliefs in their abilities to achieve a task, which can impact performance and retention. Research suggests that self-efficacy can be developed through in-person social...
- Keyword:
- Computer-Supported Cooperative Work, Human Computer Interaction, Newcomers, Mentorship, Social Support, and Self-Efficacy
- Subject:
- Computer science and Communication
- Creator:
- Harburg, Emily Kathryn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14413 and etdadmin_upload_618138
-
- Description:
- Economic and political processes are heavily intertwined. Political processes put constraints on economic activity while economic development influences the way the political system operates. This interconnection is especially tight in developing countries and transition economies with less secure property rights, less stable political institutions, and more rapid economic changes. In...
- Keyword:
- Conflict, Political Parties, Social Media, Political Economy, and Development Economics
- Subject:
- Economics
- Creator:
- Makarin, Alexey
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14652 and etdadmin_upload_662665
-
- Description:
- Cancer progression is a complex process, leading to metastatic spread of primary tumor cells that colonize distant vital organs and mortality if not stopped. Since clinical strategies to stem this progression are still being developed, it is of great importance to detect this end stage metastatic spread as early as...
- Keyword:
- Coral, Light scattering, Optical coherence tomography, Tissue Engineering, Biomaterials, and Cancer detection
- Subject:
- Biomedical engineering, Medical imaging, and Zoology
- Creator:
- Spicer, Graham Lorne Cameron
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_660896 and http://dissertations.umi.com/northwestern:14594