Systems of accountability for police who violate the U.S. Constitution are broken. Among other mechanisms of accountability, the judicial system should provide a path for victims to obtain a remedy when their constitutional rights are violated. Yet unless the law is clearly established beyond debate, the doctrine of qualified immunity...
Bio-integrated electronics with advanced monitoring capabilities have garnered considerable interest as a means of expanding patient care beyond traditional hospital and clinic settings. These mechanically soft microsystems, many of which are bioresorbable and wireless, have the potential to replace bulky, rigid, and wired medical technologies by matching or exceeding their...
This dissertation explores accounting information's role in forming R\&D alliances and subsequent innovation. Specifically, I utilize the effect of the recent revenue recognition rule change, Accounting Standard Codification (ASC) 606, on drug development firms. ASC 606 allows managers to change revenue recognition timing and increases disclosure requirements. I first document...
``Hazy decisions: The effect of dementia on medical decision-making'' \\ I estimate the causal effect of having dementia on the course of treatment for unrelated diseases by leveraging differences in the relative time of onset of dementia and the other condition in a difference-in-differences event-study framework. To demonstrate this approach...
Lithium-ion battery technology is a critically important component of the emerging renewable energy infrastructure. Since battery technology was first commercialized in the 1990s, significant progress has been made in materials development, motivated by the prospect of higher energy and power densities, increased cycling longevity, and faster charging and discharging rates....
Every day, we communicate through computers on projects ranging from a group lunch order to booking a flight to learning critical medical information. And every day, we also miscommunicate through computers: We don’t pick up on an intentionally humorous response, or we miss the criticality of a request. This is...
SCN2A encodes the NaV1.2 voltage-gated sodium channel, which is thought to contribute to the development of the central nervous system. Pathogenic variants in SCN2A have been associated with neurodevelopmental disorders (NDD), including developmental and epileptic encephalopathies (DEE), intellectual disability (ID), and autism spectrum disorder (ASD). These disorders represent a significant...
The speed of the storage device has long lagged behind the computation speed of processors.As a result, the I/O performance of storage systems in a supercomputer fails to keep up with its computational power.
This gap continues to widen in modern supercomputers.
On future exascale supercomputers, this issue can worsen...
Visual processing often requires the coordination of different neurophysiological regions in the visual system to independently represent and then re-integrate the different features of an object to gain an accurate and coherent representation of that object. Yet, under certain circumstances, this process can go awry and result in illusory misbindings,...
The basal ganglia operate largely in closed parallel loops, including an associative circuit for goal-directed behavior originating from the dorsomedial striatum (DMS) and a somatosensory circuit important for habit formation originating from the dorsolateral striatum (DLS). An exception to this parallel circuit organization was proposed to explain how information is...