Imagine someone who was raised to hold a number of irrational and objectionable beliefs. There seems to be an important sense in which they lack control over these beliefs, and so we might think they are not responsible for them. But many of our beliefs are like this: they are...
Heart failure due to genetic cardiomyopathy is associated with a range of phenotypic expression. The studies in this body of work interrogated the role of noncoding variation in modifying cardiomyopathy phenotypes. We used cap analysis of gene expression in heathy and failed left ventricles to define the regulatory environment of...
The U.S. population is rapidly changing with recent projections showing that soon whites will no longer be the majority. This information, when shown to white Americans, can generate a sense of threat. Across the three studies of this dissertation, I frame this group threat (i.e., a change in the demographic...
Pharmaceutical companies pay more than $2 billion to physicians every year. Most of these payments are for food and beverage, speaking, honoraria, consulting, and travel and lodging, which are termed “general payments.” These payments have come under increased scrutiny as critics of pharmaceutical promotion argue that they influence prescribing in...
Lower-SES (socioeconomic status) couples tend to face more challenges in their relationships. Relative to higher-SES couples, they are less likely to marry, more likely to divorce, and less satisfied with their relationships—but they do not value their romantic relationships any less. Drawing on risk regulation theory and theories of social...
This dissertation focuses on the development of quantitative approaches for characterizing endogenous signaling pathways and designing new pathways in mammalian cells. I demonstrate how mathematical descriptions that are formulated to explain gene expression patterns can also serve as a powerful springboard for deeper analyses into the properties and functions of...
This dissertation explores how American television portrayed canonical European classical music in the Cold War era. I analyze televisual negotiations of music-cultural hierarchies to complicate common narratives about the postwar decades as a peak moment of polarity between “high” and “low” culture, and between ideologies of consensus and rebellion. Drawing...
The world is awash in data and much of artificial intelligence focuses on learning models of the underlying structure in this data or the mechanisms governing its evolution. Both neural and symbolic models have weaknesses that make these models sub-optimal from a use perspective. Much of this data is in...
People need to feel authentic at work, but authenticity is not always a priority in organizations. This dissertation shows feeling authentic is essential to feeling human. Chapter 1 provides an overview of research on authenticity and self-dehumanization, describing why feeling inauthentic leads to self-dehumanization. Chapter 1 empirically supports the association...
This study aims to explain variations in student movement successes and failures during regime transitions. Examining the 1998–99 Indonesian student movement that helped ending the Suharto regime, this study argues that the degree of state repression influences the degree of coordination and assistance from opposition groups and actors to students,...
In my dissertation, I unveil a concept of the dramatic protagonist in Soviet drama that I propose to call a modern superfluous man. To note, this is not an attempt to trace the entirety of the superfluous man tradition from its origins to the present but rather a selective consideration,...
Singlet Fission (SF) is a down-conversion process in organic chromophores where one high-energy singlet exciton is converted into two low-energy triplet excitons. Such carrier multiplication aspects of SF are promising in increasing the solar cell efficiency. The generation of two bound spin triplet states from the same singlet exciton also...
Constrained optimization problems are prevalent in all areas of science and engineering, and many well-known numerical methods have been developed to solve these problems. Yet, when there exists random quantities in the model under consideration, most of the deterministic methods are no longer effective. In this dissertation, we address parameter...
Current prediction instruments for violent recidivism lack accuracy as recidivism rates for violent offenses remain high (Fazel & Wolf, 2015). Part of the issue may be the conceptualization of violent offenders as a homogenous group as opposed to heterogeneous subgroups. Additionally, various studies suggest that cognitive abilities in violent offenders...
The three-dimensional (3D) nanoscale structure of III-As nanowires is correlated with optical and electronic property measurements to deconvolve the contributions of strain, composition, and crystal structure to characteristics of interest for future electronic and optoelectronic devices. Multiple advanced two-dimensional (2D) and 3D characterization techniques are employed such as atom probe...
This dissertation is a performance ethnography that chronicles the experiences of Black and Latinx transgender women in the ballroom scenes of Chicago, Illinois and London, England. The dissertation engages 65 Black and Latinx transwomen and offers a theory of embodied knowledge—that is, the harnessing of lived experiences of racial, gender,...
In nature, materials with complex architectures are formed through hierarchical self-assembly. Therefore, the study and design of hierarchically assembling materials is important in producing materials that mimic biological structures and is a key challenge in biomaterials science and engineering. In articular cartilage, hierarchical assembly of extracellular matrix (ECM) components provides...
The study of employee engagement and its consequences in the workplace has gained traction in the business world over the past decade, with dramatic claims of the direct consequences of engagement including lower absenteeism, higher sales, improved productivity, and increased profitability for organizations that are more engaged (The Gallup Organization,...
There is considerable technical interest in the improvement of battery technology, as it would allow for the enhancement and realization of many different applications, including the continued miniaturization of portable computational devices, plug-in electric vehicles, and intermittent power storage. Lithium metal represents a theoretical limit on the anode energy density...
Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused CRISPR/Cas9 genetic screen and uncovered that loss of genes encoding...
As demonstrated by efforts in graphene commercialization, scalable synthesis and high-quality material availability are primary limiting factors for the realization of technologies based on two-dimensional (2D) materials. Thus, in considering the fate of emergent 2D materials such as the metal chalcogenides, the challenge of scalable synthesis is a highly relevant...
In the first chapter, I present a theory of measurement of preference intensity and use this measure as a foundation for utilitarianism. To do this, I suppose each alternative is experienced over time. An individual has preferences over such experiences. I present axioms under which preferences are represented by an...
This thesis studies social protest in colonial Korea (1910-1945). In the first two chapters, I study protest by Koreans against the Japanese colonial authority. In particular, I focus on the March First Movement in 1919, the largest anti-colonial independence movement during the colonial era, and examine its propagation (chapter 1)...
In this thesis, we study the geometry of planar shapes and their harmonic caps. Specifically, given a compact continuum $P$, we are interested in constructing a planar cap $\hat P$ such that $P$ and $\hat P$ can be glued together along their boundary to form a topological sphere with prescribed...
Many theories of categorization have included an intuitive role for our ability to detect and judge similarity. Yet, this important role of similarity processing has been disputed. This research adopts a model of similarity processing through structure mapping (Gentner, 1983) to explore its role in similarity processing and categorization. Relational...
Navigating through the world is typically a multisensory experience. Mammals are believed to navigate using a cognitive map of space stored in the hippocampus. Yet, it is unclear how and whether spatial information of different sensory modalities can contribute to this map. A major barrier to addressing this question has...
Friction modulation technology developed over the past decade now enables the creation of rich textural effects on flat haptic displays. However, an intuitive and manageably small design space for construction of such haptic textures remains an unfulfilled goal for user interface designers. In this thesis, I explore perceptually relevant features...
The thesis is concerned with the design and control of large-scaled queueing systems that are operated under heavy traffic, focusing on the following two research questions: For a given queueing system, how to find a proper heavy-traffic limit that accurately approximates various performance metrics? For multi-class queueing systems, how to...
Search engines and social media are two ubiquitous modes of accessing Web information, and they dictate what information people view, influencing their thoughts and beliefs and potentially shaping their opinions about news and facts. Network effects propagate the beliefs, often magnified, disseminating information rapidly and leaving little time for fact...
Three-dimensional (3D) imaging has been widely used in academic research and industrial applications. Compared to 2D representations, 3D imaging can yield more information about geometric structures of an object such as small surface variations that are difficult to perceive otherwise. 3D image contents provide additional information that is complementary to...
In this dissertation, I combine quasi-experiments and computational tools with large-scale data in new ways to address questions that revolve around the Matthew Effect of status. My dissertation is a collection of four empirical papers on status at both the organizational and the individual levels. I employ two distinct empirical...
Carbonates constitute Earth's largest carbon (C) reservoir, with most shallow marine deposition occurring on the low-latitude carbonate platforms covering ~800,000 km2. The Yucatán Platform situated between the Western Caribbean and Gulf of Mexico basins, is one of the largest present-day carbonate platforms. As with post-Paleozoic carbonates generally, it is readily...
Speech recognition in complex acoustic environments is dependent on myriad bottom-up (i.e., peripheral) and top-down (i.e., central) processes. While bottom-up processes remain fairly stable during childhood, the development of top-down processes persists into young adulthood. The immaturity of top-down processes places younger children at considerable risk for poorer speech recognition...
Optimization via simulation (OvS) is the practice of minimizing or maximizing the expected value of the output of a stochastic simulation model with respect to controllable decision variables. Stochastic simulation is a standard tool within operations research and is often required to model complex systems subject to uncertainty where it...
Proper partitioning of mitochondria and mtDNA is critical for cellular health. Investigations into mitochondrial inheritance, specifically how mtDNA inheritance is coupled with the inheritance mitochondrial compartment, are still in the early stages. We use budding yeast as a model polarized cell system to study a mitochondrial Myo2-adaptor protein, Mmr1, in...
The study and design of machines that are able to analyze the auditory scene and organize sound into parts that are perceptually meaningful to humans is referred to as machine hearing. Such machines are expected to distinguish between different sound categories (e.g., speech, music, background noise), focus on a sound...
Intelligence in humans is largely characterized by the ability to encode information into compressible representations to facilitate efficient communication for collaboration and learning. The goal of this thesis is to enable robots to both learn and act on compressible representations in real-time. I show how active exploration with respect to...
While optimization has received much attention in the machine learning community, most of them consider unconstrained supervised learning models such as neural networks and support vector machine. In this dissertation, we introduce a new class of optimization problems called scale invariant problems that include interesting unsupervised learning models such as...
This thesis focuses on applications of recurrent neural networks (RNNs) for three aspects of sequential classification. In the first chapter, a novel method to generate synthetic minority data generation to improve imbalanced classification is discussed. Generative Adversarial Networks (GANs) have been used in many different applications to generate realistic synthetic...
Two major areas of research in the field of manufacturing are miniaturization and 3D printing. The trend towards miniaturization stems from the desire and need for additional functionality and improved performance for products with ever-smaller footprints. Miniaturization opens manufacturing to new applications such as tissue engineering and surface texturing. Meanwhile,...
Social factors are a major contributor to deaths in the US. The literature suggests that socioeconomic status and other social and environmental factors influence an individual’s mortality. These factors encompass six domains that comprise factors such as poverty, unemployment, poor access to healthy food, limited access to health care, limited...
Social media and online forums provide spaces where people can gather beyond restrictions of geographic proximity. For some individuals with mental illness, these spaces are vital; providing outlets and communities where a multitude of experiences are accepted and understood, rather than judged against normative, often ableist standards. For nearly three...
Granular mixing has received less attention than fluid mixing due to the unique properties of granular materials and the complexity of their flow behaviors. Unlike fluid flows, where a continuum perspective accurately captures flow behavior, neither a continuum nor a discrete perspective by itself can describe the global behaviors of...
Bacteria often coordinate virulence factors to fine-tune the host response during infection. These coordinated events can include toxins counteracting or amplifying effects of another toxin or though regulating the stability of virulence factors to remove their function once it is no longer needed. Multifunctional autoprocessing repeats-in toxin (MARTX) toxins are...
Surface appearance represents the sense impression of the surface. In visual art, the artists try to use the appearance of their artworks to express their mental state and philosophy. Researchers in the cultural heritage community has been trying to use different analysis approaches to interpret artworks. In Computer Graphics and...
Esophageal hypervigilance, or the increased awareness and amplification of esophageal symptoms, is a psychological process known to drive symptom experience in individuals with gastroesophageal reflux disease (GERD). However, current understanding lacks a conceptual framework with known biomarkers and relationships to other psychophysiological variables. The aim of the current study is...
ABSTRACT On the Other Side of Babylon: Black Women and Epistemologies of Resistance in the Third World Women’s Alliance Assata Sankofa Kokayi This cultural and intellectual history analyzes the Third World Women’s Alliance (TWWA), its relationship with decolonization struggles in Africa, Asia, and Latin America, and positionality as an anti-imperialist...
In the current state of robotics, the systems we create are heavily reliant on our consistent guidance, programming of tasks, and oracle information that allow them to operate in the world that we inhabit. What happens to our robotic systems when we are unable to perform as an oracle, creating...
Colloidal crystals are promising candidates for nanophotonic applications due to their strong interactions with light and the capability to tailor such interactions through crystal design and engineering. DNA-programmable assembly, in particular, allows for precise structural control down to the sub-nanometer length scale. In this thesis, ways of designing, synthesizing, and...
Peer review is a commonly used tool to manage large classes. It allows students to grade and provide feedback to each other based on rubrics provided by instructors. Peer review has been proved to be effective in improving students' learning outcomes by many research. During providing peer review, students are...