In this paper, Morgan and Orloff survey the contemporary study of states in the social sciences. They begin by tracing the history of scholarship on the state. The authors identify six main clusters of research on states that emerged through the effort to “bring the state back into” history and...
This paper examines the relationship between a party'’'s descriptive representation of women and its ideological proximity to female and male voters. I find that male and female voters are both objectively closer to parties with more females in their delegations. However, males are more likely to subjectively assess parties with...
In order to make informed policy recommendations, development research faces two broad challenges: first, to identify and estimate the effects of interventions where they have occurred, and second to build and test theories about the effects that a related intervention would be hypothesized to exert in a different context. I...
This work reports studies on the physical properties of collections of nanosheets. First, the configurations of graphene oxide sheets in solution are studied. Polarized optical microscopy reveals quickly and decisively that sheets remain flat and form lyotropic liquid crystals over a wide range of solvent conditions. When solvent conditions are...
The cellular abundance of mature microRNAs (miRNAs) is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs) into pre-miRNA intermediates. The Microprocessor complex, composed of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor's differential processing of various pri-miRNAs. Here, I show...
This dissertation describes the fundamental studies of photoinduced charge-carrier transfer from colloidal metal chalcogenide quantum dots (QDs) to surface-adsorbed molecular redox partners. In addition, we also present the use of visible-light absorbing QDs in photocatalytic applications. CdS QDs are used as photocatalysts in a C-C coupling reaction, in which no...
Penelopian Figures: Narratives of Work and Resistance in American Literature, 1840-1900” examines literary representations of workers who engage in covert opposition to their circumstances. In chapters on The Lowell Offering textile magazine, Rebecca Harding Davis’s Life in the Iron Mills, Louisa May Alcott’s “How I Went Out to Service” and...
When granular materials with different properties (size, shape, density, etc.) flow, they tend to segregate. This research addresses a specific form of segregation (axial segregation) that occurs when size bidisperse granular mixtures flow inside a rotating cylindrical tumbler. Axial segregation is the formation of alternating bands of different particle species...
Metallic nanowires have become functional elements in many electronic devices such as the latest fin-FET (field effect transistor) from Intel, which has metallization layers with pitch as small as 90nm, flexible electronics, touch screens and nanoelectromechanical systems. This wide applicability of nanowires warrants extensive characterization of their fundamental properties such...
This work is a collection of articles featuring applications of operations research primarily on solid organ transplantation. At the time of writing, 111,434 Americans were waiting for a liver or kidney transplant. Only 26,901 transplants were performed last year – a consequence of the scarcity of organ donors and the...
Psychophysiological investigations of human sexuality have revealed more complexity than might be naively assumed. The sexual arousal patterns of heterosexual and homosexual men are relatively straightforward, with both groups showing substantial responses to erotic stimuli of their preferred sex and much smaller responses to their nonpreferred sex. Bisexual men, in...
The development of organic photovoltaic devices benefits from understanding the fundamental processes underlying charge generation in thin films of organic semiconductors. This dissertation exploits model systems of π-stacked chromophores such as perylene-3,4:9,10-bis(dicarboximide) (PDI) and 3,6-bis(aryl)diketopyrrolopyrrole (DPP) to study these processes using ultrafast electronic and vibrational spectroscopy. In particular, the characterization...
Humans have a remarkable ability to walk on a variety of surfaces. Compliant, uneven, or even slippery surfaces present little challenge to most people, yet are hazardous to individuals with locomotor impairments and even to bipedal robotic systems designed to mimic what we understand about human locomotion. Our ability to...
Our visual system organizes lines, shapes, and colors into groups, objects, and scenes. This dissertation explores how these higher-level organizations arise, focusing on the contribution of feature-based attention, our ability to selectively enhance a color, shape, or orientation across our visual field. I will present evidence that feature-based attention enables...
Algorithmic trading (AT) has grown dramatically in recent years and now makes up over half of all trades and orders in the market. I investigate whether and how AT affects voluntary disclosure by managers. I hypothesize that AT’s differential ability to process information and its speed of trading affects how...
Thin film oxidation is investigated using two modeling techniques in the interest of better understanding the roles of space charge and non-equilibrium effects.
An electrochemical phase-field model of an oxide-metal interface is formulated in one dimension and studied at equilibrium and during growth. An analogous sharp interface model is developed...
“Quartering the Wind” explores the unorthodox, unstable, and seditious political values that undermined early modern English arguments for what is “natural” in human governance. I examine texts that expose a politically intricate natural world that serves no single model of orthodox politics. While ecocritical treatments of political analogies drawn from...
This dissertation argues that by examining the networks and advocacy of Americans interested in Lebanon and Lebanese with ties to the U.S., scholars can better understand how relationships cultivated away from the spotlight of policymaker attention have both guided and revealed the limitations of U.S. empire. Activists, both Lebanese and...
Victorian novels’ characteristic preoccupation with marriage and inheritance has led scholars to view the form as socially conservative in the mid-nineteenth century. Yet contemporary commentators feared what young women might conceive as a result of reading. The key to this dilemma, I argue, is the usual consequence of nineteenth-century marriage...
This dissertation seeks to make sense of the recurring anachronism of aristocracy within early twentieth-century French culture, especially in literature and film. Most studies present the aristocrat as simply one among many examples of the nostalgia, reaction and fascination with the archaic that constituted an important intellectual and artistic tendency...
Bacterial biofilms are aggregates of cells that adhere to nearly any solid-fluid interface. While many have harmful effects, such as industrial damage and nosocomial infections, certain biofilm species are now generating renewable energy as the fundamental components of Microbial Fuel Cells (MFCs). In an MFC, bacteria consume organic waste and,...
In fish, caudally propagating waves of neural activity produce muscle bending moments. These moments, coupled with forces due to the body's elastic properties and forces due to fluid-body interactions, determine the deformation kinematics for swimming. Fully resolved simulations of neurally-activated swimming can be used to decode activation patterns underlying observed...
This dissertation explores how the environment shapes energy expenditure and cardio-metabolic disease risk by investigating multiple timescales of adaptation to cold stress among the Yakut, an indigenous circumpolar population. This study pursues three main objectives. First, the adaptive and health significance of brown adipose tissue (BAT) is explored by examining...
This project examines how early modern writers mobilize race as a vehicle for investigating far-reaching epistemological questions about the limits and parameters of human knowledge. While dominant trends in early modern race studies have focused on racial knowledges or particular identifications or formulations of human difference, I break new ground...
Large projection neurons of the cerebellar nuclei (CbN cells), whose activity generates movement, are inhibited by Purkinje cells and excited by mossy fibers. The high convergence, firing rates, and strength of Purkinje inputs predict powerful suppression of CbN cell spiking, raising the question of what activity patterns favor excitation over...
The goal of science education is to prepare students to make decisions about the complicated socioscientific issues that are an inescapable part of modern life, from personal medical decisions to evaluating a political candidate's environmental platform. We cannot expect adults to maintain a deep conceptual understanding of the current state...
Ions dissolved in solution are known to interact in remarkable ways with charged Langmuir monolayers. The organic monolayer can be used as a molecular template for ordered nucleation of inorganic crystals (biomineralization) and functional nanoparticles. However, the clear majority of experiments demonstrating these behaviors have been performed with divalent ions....
Humans possess the ability to infer and track mental states, which allows for successful interaction in the social world. The collection of processes and representations that makes this possible is referred to as a theory-of-mind (ToM). A large body of work has examined how these abilities develop from infancy to...
Microkinetic modeling is a powerful tool for creating dynamic and quantitative descriptions of complex systems. These detailed mechanistic models compliment experimental techniques and provide an ability to achieve deeper insights into chemical processes where numerous intermediates are highly reactive and difficult to quantify in the laboratory. This thesis discusses the...
The work presented in this dissertation examines the interplay between electron transfer reactions and electron spin in photoactive organic molecules. Organic compounds that undergo electron transfer reactions after absorbing light are important in natural photosynthesis, photobiology, and synthetic photovoltaics. These electron transfer reactions depend on the spin states of the...
As neuroscience seeks to understand larger, more complicated systems and behaviors, we will require neural recording techniques that can monitor the activity of neurons across the whole brain. The unparalleled data-storage capabilities of DNA, combined with fast, genetically encodable DNA polymerase-based sensors, would allow for "ticker tape"-like recordings of neurons...
Chemical probes are versatile and unique tools for biomedical research. A chemical probe is simply a selective small-molecule modulator of protein function that allows the user to ask mechanistic and phenotypic questions about its molecular target in biochemical, cell-based or animal studies. Experiments involving selective inhibitors can help delineate key...
Contained in the following dissertation are detailed investigations regarding the thermodynamics of small molecule activation by metalloporphyrin complexes isolated within metal-organic frameworks (MOFs). Chapter 1 provides a description of the role metalloporphyrin complexes play in biological systems and the challenges associated with studying small molecule activation by metalloporphryin sites in...
Methanobactins (Mbns) are a growing family of ribosomally produced, post-translationally modified natural products that exhibit a high affinity for copper. These compounds were initially identified in methanotrophic bacteria, which oxidize methane to methanol as their sole source of carbon. One of the key enzymes in this metabolic pathway, particulate methane...
Technology has advanced rapidly, especially in the twenty-first century, influencing our day-to-day life on unprecedented levels. Most such advances in technology are closely linked to, and often driven by, the discovery and design of new materials. It follows that the discovery of new materials can not only improve existing technologies...
This dissertation looks at the consequences of three different government regulatory policies---the nondistribution constraint (which prohibits managers of nonprofit organizations from distributing profits generated by the nonprofit organization to themselves), the 100/0, 85/15, and 90/10 rules (which restrict the fraction of revenue for-profit colleges and universities can receive from Title...
As a variety of social capital, scholars’ traditional understanding of a producer’s status is difficult to carry over from one market context to another. However, from organizations seeking to hire rainmakers away from competing organizations within the same markets to producers expanding their offerings into adjacent (and sometimes distant) markets,...
This dissertation provides an account of the richest people in Glasgow and Liverpool at the end of the nineteenth and beginning of the twentieth centuries. It focuses on those in shipping, trade, and shipbuilding, who had global interests and amassed large fortunes. It examines the transition away from family business...
While synthesis and transformation processes to produce monodisperse nanoparticles are empirically well-developed, the pathways for these reactions as well as the exact role of synthetic agents and binding characteristics of surface moieties remain poorly understood. This lack of understanding is primarily due to the paucity of information about nanoparticle structural...
Small hydrocarbons and their oxygenated derivatives are critical to atmospheric organic aerosol formation and growth. Secondary organic aerosols (SOAs) constitute a significant portion of total atmospheric organic aerosols, and are often generated through the oxidation of biogenic volatile organic compounds (VOCs) such as isoprene, -pinene, and -caryophyllene. Interfaces of SOA...
Electromagnetic metamaterials composed of colloidally synthesized plasmonic metal nanoparticles offer new opportunities to probe light-matter interactions. The properties of these structures largely depend on the spatial arrangement of nanoparticles within them. Therefore, new assembly strategies that afford a high level of structural control are expected to enable a broad range...
Optical interferometry is a powerful technique which has been widely utilized for well over a century in making the world’s most precise measurements. By measuring how the interference between two waves is affected by a physical process, one can deduce the magnitude of this process. Because the wavelength of a...
The electronic spin state (S) of metal ions is fundamental to the performance of magnets, protein cofactors, and magnetic resonance imaging (MRI) contrast agents. The ability to manipulate the spin state of transition metals allows for the development of advanced materials with emergent properties. This following chapters will introduce two...
Starting materials for natural products, ideally synthesized using low-cost, highly active and selective catalysts, are of great interest to the pharmaceutical industry. Relevant reactions include the synthesis of 1,2-dihydropyridines, reduction of ketones/aldehydes, cleavage of esters, and reduction of amides to amines. Hydroelementation is an important catalytic process that involves H-E...
The renewed scholarly interest in the connections between taxation, state building efforts, and long-term economic development has revitalized the study of historical tax systems. How did today’s states initially acquire ‘fiscal capacity’, and why was this process more successful in some places than in others? Since African tax systems are...
Certain inducible genes show faster reactivation if they were recently expressed. This epigenetic phenomenon is called transcriptional memory and is inherited for several generations after the first round of induction. During this phase, genes show several conserved molecular features that are essential for faster reactivation: peripheral localization of the gene,...
These files include source datasets for the article "Multipartite stabilization of the C. beijerincki pfl ZTP aptamer disfavors terminator hairpin folding by gating strand invasion". RELATED ARTICLE: Strobel, E.J., Cheng, L., Berman, K.E. et al. A ligand-gated strand displacement mechanism for ZTP riboswitch transcription control. Nat Chem Biol 15, 1067–1076...
This dissertation consists of three essays in applied microeconomics. In the first chapter, I introduce a new statistical test for identifying prejudice from empirical data. In the second chapter, I (joint with James Schummer) consider the revenue maximization problem for a two-sided, one-to-one matching platform. In the third chapter, I...
This dissertation uses several interrelated methods derived from corpus linguistics, statistics, and machine learning to infer a number of historically significant voice-leading schemas in a corpus of eighteenth-century Neapolitan solfeggi (exercises for voice with bass accompaniment). The goal of this work is to gain insights not only into the characteristics...