Efficient and sustainable utilization of global resources represents a grand but achievablechallenge. By leveraging biology, we can transform abundant, but recalcitrant resources like lignin
to products ranging from fuel to medicine to polymers. Efforts to do so are expansive, but
challenges remain, due in no small part to the difficulty...
Situated at the intersection of literary, religious, and economic studies, this dissertation examines how late medieval writers used commercial practice to invent new modes of penitential piety. Challenging scholarship that characterizes the relationship between church and commerce as exclusively antagonistic or corrosive, I argue that the convergence of these two...
Conventionally cross-linked polymers, which comprise the vast majority of commercial thermosets, cannot be decross-linked after curing or flow upon heating. Therefore, they cannot be effectively recycled into high-value products at end-of-life. Their lack of recyclability is due to the permanent cross-links, which restrict the flow of the chains in the...
Popular histories of United States mass incarceration often focus on federal wars on crime, law and order policing, and the passage of harsh sentencing laws to explain how the United States transformed into the world’s leader in incarceration. My dissertation on the crisis of state prison overcrowding and prisoner resistance...
In this thesis, we discuss classical and recent results around the damped wave equation on compact and noncompact manifolds. We firstly show that on asymptotically cylindrical and conic manifolds, the geometric control condition and the network control condition give exponential and logarithmic decay rates respectively. We then show that a...
Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...
This dissertation focuses on two topics in international macroeconomics: the identification of the international spillovers of US interest rate shocks, and the study of its main transmission channels. In Chapter 1, I present the Spillover Puzzle of US Monetary Policy - the fact that in response to a US interest...
Bio-integrated electronics with advanced monitoring capabilities have garnered considerable interest as a means of expanding patient care beyond traditional hospital and clinic settings. These mechanically soft microsystems, many of which are bioresorbable and wireless, have the potential to replace bulky, rigid, and wired medical technologies by matching or exceeding their...
Every day, we communicate through computers on projects ranging from a group lunch order to booking a flight to learning critical medical information. And every day, we also miscommunicate through computers: We don’t pick up on an intentionally humorous response, or we miss the criticality of a request. This is...
The basal ganglia operate largely in closed parallel loops, including an associative circuit for goal-directed behavior originating from the dorsomedial striatum (DMS) and a somatosensory circuit important for habit formation originating from the dorsolateral striatum (DLS). An exception to this parallel circuit organization was proposed to explain how information is...