The formation of neuronal inclusions is one of the hallmarks of neurodegenerative diseases. These structures are composed of aggregated proteins, molecular chaperones, and components of the ubiquitin-proteasome system (UPS). Co-localization of aggregated proteins with cell-homeostasis maintaining machinery indicates that the cell may be failing in an attempt to clear these...
In 2011, after just eighteen days, from January 25 to February 11, the Egyptian public overthrew the 30-year-long dictatorship of Hosni Mubarak. A decade afterward, we sought to have Egyptians reflect on the collective memory of those days. What fueled the revolution? Was it successful? Did it lose its way?...
The work presented in this dissertation focuses on ceramic anode materials for solid oxide fuel cells (SOFCs). The primary goal was to characterize the anode and relate the electrochemical behavior to the microstructure. The anode that was most extensively studied in this work was a composite of Gd0.10Ce0.90O1.95 (GDC) and...
Sensing is a fundamental operation for almost any motion-based system. We have chosen electrosensory systems as a platform to explore sensing and control in both artificial and biological systems. Electrosense is a convenient sensing modality because artificial electrosensory systems are relatively simple to implement, and weakly electric fish have some...
Since Reduced Emissions from Deforestation and Degradation “Plus” (REDD+) starting gaining traction in the UN climate negotiations in 2007, its architects and scholars have grappled with its community-level justice implications. On the one hand, supporters argue that REDD+ will help the environment and forest-dependent communities by generating payments for forest...
CD4-positive T cells express ligands for E- and P-selectins, carbohydrate-binding adhesion molecules that are induced on inflamed endothelium. The interaction between selectins and the selectin ligands facilitates the migration of T cells to sites of inflammation. The fucosyltransferase FucT-VII is essential for selectin ligand formation but the signaling and transcriptional...
Counteranion effects on the rate and stereochemistry of propylene polymerization mediated by ion-pair complexes derived from dimethylzirconocene precatalysts activated with strongly Lewis-acidic perfluoroarylmetalloid cocatalyst/activators are shown to arise from the strength of the cation-anion interaction. This is quantified using CS-symmetric Me2C(Cp)(Flu)ZrMe2 (Cp = C5H4, η5 cyclopentadienyl; Flu = C13H8, η5...
The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...
The dissertation analyzes five well-known “Bildungsromane” published roughly between 1785 and 1914 (Karl Philipp Moritz’s Anton Reiser (1785), Johann Wolfgang von Goethe’s Wilhelm Meisters Lehrjahre (1795), Gottfried Keller’s Der grüne Heinrich (1879), Franz Kafka’s Der Verschollene (1914), Thomas Mann’s Die Bekenntnisse des Hochstaplers Felix Krull (1913/1955)) and investigates the ways...
Analytical lower and upper bounds for the average error probability in M-ary quantum detection are derived. The upper bound is valid when the state ensemble, which can consist of pure or mixed states, satisfies a certain linear independence condition. The lower bound is generally valid and also has a classical...