Altered Neurodevelopment in Youth with Perinatally-Acquired HIV: Analyses of Grey Matter Spatial Distribution Patterns Using Structural Magnetic Resonance ImagingPublic Deposited
Worldwide, youth living with perinatally-acquired human immunodeficiency virus (PHIV) are at increased risk for cognitive dysfunction and developmental delay. Effects of the virus, chronic inflammation, and combination antiretroviral therapy (cART) during critical periods of brain development may disrupt normal cognitive development. Neuroimaging studies using structural magnetic resonance imaging (sMRI) allow for in vivo macrostructural and microstructural characterization of the grey matter of the brain. Relationships between PHIV status, HIV disease severity, cognitive function, age, and grey matter spatial distribution patterns were explored. It will be shown that youth with PHIV have reduced global and local grey matter integrity, and that this disrupted integrity is associated with worse HIV disease severity and worse cognitive performance. This cross-sectional study of the grey matter of the brain of youth with PHIV gives insight into the altered neurodevelopment of youth living with PHIV.
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