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Progress toward "Click"-based Small-molecule DNA Hybrids Part II: Di- and Tri-functionalized Core

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This paper reports the syntheses of acetylene-terminated smallmolecule cores. Also reported are successful attempts at “click” coupling the core molecules with azide-terminated oligonucleotides to construct stable small-molecule DNA hybrids (SMDH). Once these click-based small-molecule DNA hybrids are formed, melting studies will be done that study how the geometry of SMDH aggregate systems affects the suspected sharp melting transitions.

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  • 07/24/2018
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