The diverse circuits and functional contributions of the basal ganglia, coupled with known differences in dopaminergic function in patients with schizophrenia, suggest they may be an important contributor to the etiology of the hallmark symptoms and cognitive dysfunction experienced by these patients. Using activation-likelihood-estimation meta-analysis of functional imaging research, we investigated differences in activation patterns in the basal ganglia in patients with schizophrenia, relative to healthy controls across task domains. This analysis included 42 functional neuroimaging studies, representing a variety of behavioral domains that have been linked to basal ganglia function in prior work. We provide important new information about the functional activation patterns and functional topography of the basal ganglia for different task domains in healthy controls. Crucially however, we demonstrate that across task domains, patients with schizophrenia show markedly decreased activation in the basal ganglia relative to healthy controls. Our results provide further support for basal ganglia dysfunction in patients with schizophrenia, and the broad dysfunction across task domains may contribute to the symptoms and cognitive deficits associated with schizophrenia.

Last modified

• 05/10/2017

Creator

• Courtney E. Russell
• Vijay A. Mittal
• Jessica A. Bernard
• Raeana E. Newberry
• James R. M. Goen

DOI

• https://doi.org/10.21985/N2B19C

Publisher

• Elsevier

Alternate Identifier

• https://doi.org/10.1016/j.nicl.2017.01.034

Keyword

• meta-analysis
• schizophrenia
• neuroimaging
• Basal ganglia
• dopamine

Date created

• 2017-02-11

Related url

•  http://www.sciencedirect.com/science/article/pii/S2213158217300347

Resource type

• Article

Source

• NeuroImage: Clinical

License

• Attribution 3.0 United States